Výsledky vyhledávání - "B. Hoogeland"

Loratadine and Analogues: Discovery and Preliminary Structure–Activity Relationship of Inhibitors of the Amino Acid Transporter B0AT2

Autor: Armin Buschauer, Serena Cuboni, Klaus T. Wanner, Christian Devigny, Barbara Hauger, Georg Höfner, Sebastian Pomplun, Matthias Eder, Florian Holsboer, B. Hoogeland, Andrea Strasser, Felix Hausch

Publikováno v: Journal of Medicinal Chemistry. 57:9473-9479

B(0)AT2, encoded by the SLC6A15 gene, is a transporter for neutral amino acids that has recently been implicated in mood and metabolic disorders. It is predominantly expressed in the brain, but little is otherwise known about its function. To identif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bdad846a120317024ee963e300db93
https://doi.org/10.1021/jm501086v

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Evaluation of Synthetic FK506 Analogues as Ligands for the FK506-Binding Proteins 51 and 52

Autor: S. Gaali, Felix Hausch, C. Kress, Christian Kozany, B. Hoogeland, Andreas Bracher, R. Gopalakrishnan

Publikováno v: Journal of Medicinal Chemistry. 55:4114-4122

The FK506-binding proteins (FKBP) 51 and 52 are cochaperones that modulate the signal transduction of steroid hormone receptors. Both proteins have been implicated in prostate cancer. Furthermore, single nucleotide polymorphisms in the gene encoding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc50c364f9e960ba3d22c4f118163f4
https://doi.org/10.1021/jm201746x

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Biomimetic Screening of Class-B G Protein-Coupled Receptors

Autor: Christian Devigny, Serena Cuboni, Jan M. Deussing, Felix Hausch, Katharine J Webb, Christoph P. Mauch, Francisco Perez-Balderas, Rudolf Wachtel, B. Hoogeland

Publikováno v: Journal of the American Chemical Society. 133:8927-8933

The 41-amino acid peptide corticotropin releasing factor (CRF) is a major modulator of the mammalian stress response. Upon stressful stimuli, it binds to the corticotropin releasing factor receptor 1 (CRF(1)R), a typical member of the class-B G-prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee81e8565d398eeb8702d67bc00e578c
https://doi.org/10.1021/ja200160s

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Exploration of pipecolate sulfonamides as binders of the FK506-binding proteins 51 and 52

Autor: Y. Wang, Christian Kozany, R. Gopalakrishnan, B. Hoogeland, Felix Hausch, Sabine Schneider, Andreas Bracher

Publikováno v: Journal of medicinal chemistry. 55(9)

FK506-binding proteins (FKBP) 51 and 52 are cochaperones that modulate the signal transduction of steroid hormone receptors. Single nucleotide polymorphisms in the gene encoding FKBP51 have been associated with a variety of psychiatric disorders. Rap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0911aefe682e29acdc1a17dbb9b858
https://pubmed.ncbi.nlm.nih.gov/22455398

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Facile Synthesis of a Fluorescent Cyclosporin A Analogue To Study Cyclophilin 40 and Cyclophilin 18 Ligands

Autor: Felix Hausch, Christian Kozany, S. Gaali, Marielle Klein, B. Hoogeland

There are strong indications for the involvement of cyclophilin 40 in diseases caused by misregulation of steroid hormone receptors, like prostate or breast cancer. To identify novel inhibitors for this immunophilin, we developed a simplified fluores

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ede9210ff9bd087205b400fd0b550b
https://europepmc.org/articles/PMC4007835/

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Increasing the Efficiency of Ligands for FK506-Binding Protein 51 by Conformational Control

Autor: Uwe Koch, Y. Wang, B. Hoogeland, R. Gopalakrishnan, Christian Kozany, Andreas Bracher, C. Kress, Anne-Katrin Fabian, Felix Hausch, Alexander Kirschner

The design of efficient ligands remains a key challenge in drug discovery. In the quest for lead-like ligands for the FK506-binding protein 51 (FKBP51), we designed two new classes of bicyclic sulfonamides to probe the contribution of conformational

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ce218b4b2850e17135b2aa507a52ee
https://infoscience.epfl.ch/record/189077

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