Zobrazeno 1 - 10
of 116
pro vyhledávání: '"B. Hepburn"'
Autor:
Marvin Kischkewitz, Bruno Marinic, Nicolas Kratena, Yonglin Lai, Hamish B. Hepburn, Mark Dow, Kirsten E. Christensen, Timothy J. Donohoe
Publikováno v:
Angewandte Chemie. 134
Herein we disclose a mild protocol for the reductive functionalisation of quinolinium and isoquinolinium salts. The reaction proceeds under transition-metal-free conditions as well as under rhodium catalysis with very low catalyst loadings (0.01 mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506b5bf16f6945db1ff5af477b59e0ca
https://doi.org/10.1002/ange.202204682
https://doi.org/10.1002/ange.202204682
Publikováno v:
Chemical Science
The single point activation of pyridines, using an electron-deficient benzyl group, facilitates the ruthenium-catalysed dearomative functionalisation of a range of electronically diverse pyridine derivatives. This transformation delivers hydroxymethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ace06d55e0b559679311404a478b74
https://doi.org/10.1039/d0sc05656a
https://doi.org/10.1039/d0sc05656a
Autor:
Alexandru Grozavu, Timothy J. Donohoe, Hamish B. Hepburn, Peter J. Lindsay-Scott, Elliot P. Bailey
Publikováno v:
Chemical Science
Pyridines are ubiquitous aromatic rings used in organic chemistry and are crucial elements of the drug discovery process. Herein we describe a new catalytic method that directly introduces a methyl group onto the aromatic ring; this new reaction is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1b187f8257898d8cb109f9fe06f1a8
Autor:
Timothy J. Donohoe, Alexandru Grozavu, Peter J. Lindsay-Scott, Hamish B. Hepburn, Benjamin M. Reeves
Publikováno v:
Angewandte Chemie (International Ed. in English)
Angewandte Chemie International Edition
Angewandte Chemie International Edition
A transition‐metal‐free reductive hydroxymethylation reaction has been developed, enabling the preparation of tetrahydroisoquinolines bearing C4‐quaternary centers from the corresponding isoquinolines. Deuterium labelling studies and control ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821180a1d2e35f1b0aae97c9f340b39f
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
M. N. Hopkinson, J. K. Matsui, L.-Q. Lu, L. Wang, R. Laha, Tehshik P. Yoon, Yannick P. Rey, C. Lévêque, D. Leonori, G. Pandey, E. Speckmeier, Burkhard König, Munetaka Akita, L. Fensterbank, F. Gaida, C. Ollivier, Moritz Vollmer, Hamish B. Hepburn, T. Rovis, J. Albero, Paolo Melchiorre, M. A. Ashley, Axel G. Griesbeck, J. P. Phelan, Malte Brasholz, Takashi Koike, V. Corcé, Jan B. Metternich, W.-J. Xiao, Oliver Reiser, Spencer O. Scholz, G. A. Molander, S. B. Lang, S. M. Thullen, Y. Wei, D. A. DiRocco, M. Wang, S. Dix, Q.-Q. Zhou, Ryan Gilmour, P. Ehrnsberger, A. Ruffoni, Danielle M. Schultz, Indrajit Ghosh, Kazimer L. Skubi, Á. Gutiérrez Bonet, Kirsten Zeitler, P. Li, R. J. Mudd, Adrian G. Amador, H. García, C. B. Kelly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5717f59f0598f40c73cf449a910b0bb2
https://doi.org/10.1055/b-006-161273
https://doi.org/10.1055/b-006-161273
Publikováno v:
Photocatalysis in Organic Synthesis
This chapter details recent advances in enantioselective amine-catalyzed reactions triggered by light. By presenting a selection of pioneering studies, the chapter highlights how the combination of photochemistry and amine-mediated catalysis has crea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::014e6c6573e4e99a838936eabc105975
https://doi.org/10.1055/sos-sd-229-00133
https://doi.org/10.1055/sos-sd-229-00133
Autor:
Philip J. Smith, Peter J. Lindsay-Scott, Harish K. Potukuchi, Timothy J. Donohoe, Alexandru Grozavu, Hamish B. Hepburn
Publikováno v:
Nature chemistry. 11(3)
Aromatic rings are ubiquitous in organic chemistry and form the basis of many commercial products. Despite the numerous routes available for the preparation of aromatic compounds, there remain few methods that allow their conversion into syntheticall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69eb756dc026a9e91861bad7f11f8a03
https://pubmed.ncbi.nlm.nih.gov/30559370
https://pubmed.ncbi.nlm.nih.gov/30559370
Autor:
Paolo Melchiorre, Nurtalya Alandini, Charlie Verrier, Cristofer Pezzetta, Mauro Moliterno, Mattia Silvi, Alberto Vega-Peñaloza, Hamish B. Hepburn, Luca Buzzetti
Publikováno v:
RECERCAT (Dipòsit de la Recerca de Catalunya)
Recercat. Dipósit de la Recerca de Catalunya
instname
ACS Catalysis
Recercat. Dipósit de la Recerca de Catalunya
instname
ACS Catalysis
The direct introduction of sp3 carbon fragments at the β position of α,β-unsaturated aldehydes is greatly complicated by competing 1,2-addition manifolds. Previous catalytic enantioselective conjugate addition methods, based on the use of organome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c902fb64f6c0d5256da2f7aa3bbf5a7f
http://hdl.handle.net/2072/350695
http://hdl.handle.net/2072/350695
Autor:
Hon Wai Lam, Hamish B. Hepburn
Publikováno v:
Angewandte Chemie (International Ed. in English)
Allylrhodium species generated from potassium allyltrifluoroborates can undergo isomerization by 1,4-rhodium(I) migration to give more complex isomers, which then react with cyclic imines to provide products with up to three new stereochemical elemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1994fed705320df4ff0c060398ade8
http://europepmc.org/articles/PMC4497600
http://europepmc.org/articles/PMC4497600
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