Prediction of outcome after paraquat poisoning by measurement of the plasma paraquat concentration

Autor: M F Wilks, Michael Eddleston, B H Woollen, Lalith Senarathna, John A. Tomenson, Nicholas A. Buckley, Darren M. Roberts

Publikováno v: Senarathna, L, Eddleston, M, Wilks, M F, Woollen, B H, Tomenson, J A, Roberts, D M & Buckley, N A 2009, ' Prediction of outcome after paraquat poisoning by measurement of the plasma paraquat concentration ', QJM: An International Journal of Medicine, vol. 102, no. 4, pp. 251-259 . https://doi.org/10.1093/qjmed/hcp006
QJM: An International Journal of Medicine

Background: Paraquat is a herbicide with a good occupational safety record, but a high mortality after intentional ingestion that has proved refractory to treatment. For nearly three decades paraquat concentrationtime data have been used to predict t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a01cedc5779b80ebb46415622cbe3a
https://doi.org/10.1093/qjmed/hcp006

The Predictive Accuracy of in Vitro Measurements for the Dermal Absorption of a Lipophilic Penetrant (Fluazifop-Butyl) through Rat and Human Skin

Autor: J. D. RAMSEY, B. H. WOOLLEN, T. R. AUTON, R. C. SCOTT

Publikováno v: Toxicological Sciences. 23:230-236

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a2bd02ea78f2a5515f1fde24f2a79d8
https://doi.org/10.1093/toxsci/23.2.230

The metabolism of cypermethrin in man: differences in urinary metabolite profiles following oral and dermal administration

Autor: J. R. Marsh, W. J. D. Laird, B. H. Woollen, J. E. Lesser

Publikováno v: Xenobiotica. 22:983-991

1. The pyrethroid insecticide cypermethrin was administered orally to six male volunteers as a single dose of 3.3 mg (cis: trans 1:1) and dermally to six volunteers at a dose of 31 mg/800 cm2 (cis:trans 56:44) as a soya oil-based formulation. Urine s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388c57ced016363e69b6de8a39e9f4a3
https://doi.org/10.3109/00498259209049904

Human inhalation pharmacokinetics of 1,1,2-trichloro-1,2,2-trifluoroethane (FC113)

Autor: W. Howe, P. G. Blain, B. H. Woollen, H. K. Wilson, E. A. Guest, T. R. Auton, J. R. Marsh

Publikováno v: International Archives of Occupational and Environmental Health. 62:73-78

Seven male volunteers were exposed to atmospheric concentrations of either 1980, 4100 or 7630 mg m-3 1,1,2-trichloro-1,2,2-trifluoroethane (FC113) for 4 h. Blood and expired air samples were collected during the exposure period and for several days s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd40103961783a151a210e429e070ed1
https://doi.org/10.1007/bf00397851

Development of a sensitive assay for the determination of mevalonic acid in urine and its application to clinical studies with rosuvastatin

Autor: Paul D. Martin, P. C. Holme, B. H. Woollen

Publikováno v: Chromatographia. 55:S195-S196

A simple method is described for the analysis of mevalonic acid (MVA) in human urine involving conversion to MVA lactone (MVAL) and determination by GC-MS. A strategy is described to achieve a low limit of quantitation to overcome the constraint that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07589dc2067a3d5f82a19d216dc3e99b
https://doi.org/10.1007/bf02493380