Zobrazeno 1 - 10 of 66 pro vyhledávání: '"B. H. Stewart"'
1
Inhibition of protein tyrosine kinases or protein kinase C prevents nonspecific killer T lymphocyte-mediated tumoricidal activity
Autor: David W. Hoskin, B H Stewart
Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1356(3):333-342
The signal transduction events which govern major histocompatibility complex-unrestricted tumour cell destruction by nonspecific killer T lymphocytes induced with anti-CD3 antibody have not yet been determined. In this study we used pharmacologic inh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055c6c9384d2945be71223f472127dbd
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2
Contribution of the N-linked carbohydrate of erythrocyte antigen CD59 to its complement-inhibitory activity
Autor: S A Rollins, H Ninomiya, Peter J. Sims, B H Stewart, Ji Zhao, Alfred L. M. Bothwell
Publikováno v: Journal of Biological Chemistry. 267:8404-8410
The contribution of N-linked carbohydrate to the complement-inhibitory function of the human erythrocyte membrane glycoprotein, CD59, was investigated. Amino acid sequence analysis of tryptic peptides labeled with [3H]borohydride revealed an N-linked
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f098a6b683a63d24f63646146e1deb0
https://doi.org/10.1016/s0021-9258(18)42459-3
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3
Regulatory control of the terminal complement proteins at the surface of human endothelial cells: neutralization of a C5b-9 inhibitor by antibody to CD59
Autor: K K, Hamilton, Z, Ji, S, Rollins, B H, Stewart, P J, Sims
Publikováno v: Blood. 76:2572-2577
Functionally inhibitory antibody to the plasma membrane complement inhibitor CD59 has been used to investigate control of the terminal complement proteins at the endothelial cell surface. Antibodies against purified human erythrocyte CD59 (polyclonal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3460c4e81c18424b92b8325aa01d33
https://doi.org/10.1182/blood.v76.12.2572.bloodjournal76122572
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4
Oral delivery of HIV-protease inhibitors
Autor: L Y, Li, B H, Stewart, D, Fleisher
Publikováno v: Critical reviews in therapeutic drug carrier systems. 17(2)
Strategies for optimizing the oral delivery of HIV-protease inhibitors draw from drug discovery efforts in molecular design, drug development tools in dosage formulation, and dosage regimen considerations in clinical medicine. This review outlines th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc0aaf789b26be257167adee4daf262e
https://pubmed.ncbi.nlm.nih.gov/10820645
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5
Atorvastatin transport in the Caco-2 cell model: contributions of P-glycoprotein and the proton-monocarboxylic acid co-transporter
Autor: X, Wu, L R, Whitfield, B H, Stewart
Publikováno v: Pharmaceutical research. 17(2)
The purpose of this study was to elucidate the mechanisms by which an HMG-CoA reductase inhibitor, atorvastatin (an organic acid with a pKa of 4.46), was transported in the secretory and absorptive directions across Caco-2 cell monolayers.Caco-2 cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9fa158206f54c680ac503e38e5713e0
https://pubmed.ncbi.nlm.nih.gov/10751037
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6
Transport of pregabalin in rat intestine and Caco-2 monolayers
Autor: N, Jezyk, C, Li, B H, Stewart, X, Wu, H N, Bockbrader, D, Fleisher
Publikováno v: Pharmaceutical research. 16(4)
The purpose of this study was to determine if the intestinal transport of pregabalin (isobutyl gamma-aminobutyric acid, isobutyl GABA), a new anticonvulsant drug, was mediated by amino acid carriers with affinity for large neutral amino acids (LNAA).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::259532d95e5799311f24a881cde6ead5
https://pubmed.ncbi.nlm.nih.gov/10227706
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7
Evidence for overlapping substrate specificity between large neutral amino acid (LNAA) and dipeptide (hPEPT1) transporters for PD 158473, an NMDA antagonist
Autor: N, Surendran, K M, Covitz, H, Han, W, Sadee, D M, Oh, G L, Amidon, R M, Williamson, C F, Bigge, B H, Stewart
Publikováno v: Pharmaceutical research. 16(3)
The objective of this research was to investigate the substrate specificity of large neutral amino acid carrier (LNAA) and di/tripeptide (hPEPT1) transporters with respect to PD 158473, an NMDA antagonist.Cellular uptake studies were carried out usin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c93cd38f076c1044ff81cc9d89926e65
https://pubmed.ncbi.nlm.nih.gov/10213369
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9
Hydrophobicity of HIV protease inhibitors by immobilized artificial membrane chromatography: application and significance to drug transport
Autor: B H, Stewart, F Y, Chung, B, Tait, C J, Blankley, O H, Chan, C, John
Publikováno v: Pharmaceutical research. 15(9)
The feasibility of using hydrophobicity measurements as screens for intracellular availability in T-cells or intestinal permeability in Caco-2 cells was examined.T-cell experiments: Cells were counted, collected, then incubated with drug solution at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cbbd5136705f9681b32ad74654add44b
https://pubmed.ncbi.nlm.nih.gov/9755892
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10
Evaluation of a targeted prodrug strategy of enhance oral absorption of poorly water-soluble compounds
Autor: O H, Chan, H L, Schmid, L A, Stilgenbauer, W, Howson, D C, Horwell, B H, Stewart
Publikováno v: Pharmaceutical research. 15(7)
The purpose of this research was to examine a targeted prodrug strategy to increase the absorption of a poorly water-soluble lipophilic compound.Three water-soluble prodrugs of Cam-4451 were synthesized. The amino acid (Cam-4562, Cam-4580) or phospha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbce78ebc3b1af75a9625b8803d7a013
https://pubmed.ncbi.nlm.nih.gov/9688053
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