Výsledky vyhledávání - "B. H. Laster"

The equal effectiveness ratio: a quantitative approach to the evaluation of compounds for boron neutron capture therapy

Autor: V P, Bond, B H, Laster, L, Wielopolski

Publikováno v: Radiation research. 141(3)

The resurgence of interest in boron neutron capture therapy (BNCT) as a potential treatment for glioblastomas and melanomas has resulted in a quest to identify and synthesize candidate compounds which can physiologically target the 10B atoms to tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae32f7be37b6644a9c3fb59c1bbf1593
https://pubmed.ncbi.nlm.nih.gov/7871155

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Photon activation of iododeoxyuridine: biological efficacy of Auger electrons

Autor: B H, Laster, W C, Thomlinson, R G, Fairchild

Publikováno v: Radiation research. 133(2)

Photon activation therapy is a binary system being investigated as a potential therapeutic modality to improve the treatment of malignancies, particularly the highly lethal and malignant brain tumor, glioblastoma multiforme. Its success relies upon t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f45aa472b5cd5c15c7a895149e6ee9c
https://pubmed.ncbi.nlm.nih.gov/8438063

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An Optimized Epithermal Neutron Beam for Neutron Capture Therapy (NCT) at the Brookhaven Medical Research Reactor (BMRR)

Autor: John Kalef-Ezra, Joseph H. Goodman, Ralph G. Fairchild, B. H. Laster, S. Fiarman, E. B. Ramsay, J. Gajewski, L. E. Reinstein, V. Benary, A. Shih, R. M. Brugger, Y. Kamen, S. K. Saraf, Reinhard A. Gahbauer

Publikováno v: Progress in Neutron Capture Therapy for Cancer ISBN: 9781461364948

The first clinical trials of NCT were initiated at Brookhaven in 1951, using the Brookhaven Graphite Research Reactor (BGRR). Subsequently, the Brookhaven Medical Research Reactor (BMRR) was built primarily for clinical applications of NCT, with an i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8930038e5e0c8dd2ca585af060aa1ff
https://doi.org/10.1007/978-1-4615-3384-9_1

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Biological efficacy of boronated low-density lipoprotein for boron neutron capture therapy as measured in cell culture

Autor: B H, Laster, S B, Kahl, E A, Popenoe, D W, Pate, R G, Fairchild

Publikováno v: Cancer research. 51(17)

Low-density lipoproteins (LDLs) are known to be internalized by the cell through receptor-mediated mechanisms. There is evidence that LDLs may be taken up avidly by tumor cells to provide cholesterol for the synthesis of cell membranes. Thus, the pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0766551c481ea9268215d4bcd2e92ce1
https://pubmed.ncbi.nlm.nih.gov/1873803

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In vitro determination of uptake, retention, distribution, biological efficacy, and toxicity of boronated compounds for neutron capture therapy: a comparison of porphyrins with sulfhydryl boron hydrides

Autor: R G, Fairchild, S B, Kahl, B H, Laster, J, Kalef-Ezra, E A, Popenoe

Publikováno v: Cancer research. 50(16)

A major problem remaining in the evaluation of boronated compounds for neutron capture therapy (NCT) is the need to know the intra- or extracellular microdistribution of boron. This is a consequence of the short range of the 10B(n,alpha)7Li reaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eda2eec8f0b81b61b373bdec22223247
https://pubmed.ncbi.nlm.nih.gov/2379150

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Installation and testing of an optimized epithermal neutron beam at the Brookhaven Medical Research Reactor (BMRR)

Autor: R G, Fairchild, J, Kalef-Ezra, S K, Saraf, S, Fiarman, E, Ramsey, L, Wielopolski, B H, Laster, F J, Wheeler

Publikováno v: Basic life sciences. 54

NCT is a binary system, in which 10B is physiologically targeted to tumor and then allowed to interact with thermal neutrons generated in the treatment volume by an externally applied neutron beam. Consequently, an unusually large number of parameter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::32413fbf2e4d69dc2d019b102477b7e4
https://pubmed.ncbi.nlm.nih.gov/2268239

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Epithermal beam development at the BMRR: dosimetric evaluation

Autor: S K, Saraf, J, Kalef-Ezra, R G, Fairchild, B H, Laster, S, Fiarman, E, Ramsey

Publikováno v: Basic life sciences. 54

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a333d264e26bd4130595148960f45a3
https://pubmed.ncbi.nlm.nih.gov/2268245

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Microanalytical techniques for boron analysis using the 10B(n,alpha)7Li reaction

Autor: R G, Fairchild, D, Gabel, B H, Laster, D, Greenberg, W, Kiszenick, P L, Micca

Publikováno v: Medical physics. 13(1)

In order to predict the efficacy of boronated compounds for neutron capture therapy (NCT), it is mandatory that the boron concentration in tissues be known. Various techniques for measurement of trace amounts of boron (1-100 ppm) are available, inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ebc6ce22e35ff78013eb1a849d488dd3
https://pubmed.ncbi.nlm.nih.gov/3951409

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