Zobrazeno 1 - 10
of 49
pro vyhledávání: '"B. H. Frank"'
Autor:
J K, Malone, J H Jr, Anderson, H A, Wolpert, L L, Ilag, B H, Frank, M R, De Felippis, C D, Paavola, A L, Orr, J M, Beals
Publikováno v:
Pediatric endocrinology reviews : PER. 17(Suppl 1)
Eli Lilly and Company has played a pivotal role in the development of insulin products since its discovery in 1921. Through their dedication to pharmaceutical innovation, Josiah K. Lilly Sr. and George HA Clowes, in close collaborations with the Univ
Autor:
James E. Shields, P L Brown, L K Green, Harlan Beall Long, B. H. Frank, C Bryant, R Millican, A A Miller, David N. Brems, Ronald E. Chance
Publikováno v:
"Protein Engineering, Design and Selection". 5:519-525
Insulin analogs designed to decrease self-association and increase absorption rates from subcutaneous tissue were found to have altered stability. Replacement of HB10 with aspartic acid increased stability while substitutions at B28 and/or B29 were e
Publikováno v:
Diabetes. 39:1339-1346
Publikováno v:
Critical reviews in therapeutic drug carrier systems. 18(2)
The treatment of type 1 diabetes requires multiple, daily injections of insulin. While many improvements involving formulation adjustments have been made in an attempt to optimize therapy, clinical experience indicates that the commercially available
Autor:
B H, Frank
Publikováno v:
Developments in biological standardization. 96
Publikováno v:
Pharmaceutical research. 15(9)
The purpose of the current study was to investigate the effects of two important excipients, zinc and m-cresol, on the self-association properties of a series of monomeric insulin analogs. In this way, the effects on formulation behavior of individua
Publikováno v:
Clinical chemistry. 44(7)
We describe a rapid and simple insulin RIA in which proinsulin and conversion intermediates do not interfere. Three monoclonal antibodies (S1, S2, and S53) were selected for their specificity (directed, respectively, against the B10 region, the junct
Autor:
P, Houssa, B, Dinesen, M, Deberg, B H, Frank, C, Van Schravendijk, F, Sodoyez-Goffaux, J C, Sodoyez
Publikováno v:
Clinical chemistry. 44(7)
We describe a sensitive two-site sandwich enzyme-linked immunosorbent assay for the measurement of intact human proinsulin in 100 microL of serum or plasma. The assay is based on the use of two monoclonal antibodies specific for epitopes at the C-pep
Autor:
B H, Frank
Publikováno v:
Health systems review. 30(6)
Autor:
B H, Frank
Publikováno v:
Costquality quarterly journal : CQ. 3(1)
The attack by the Internal Revenue Service on the classification of workers who operate as independent contractors has continued unabated over the last nine years, and despite increased congressional concern regarding the Internal Revenue Service's h