Zobrazeno 1 - 10
of 116
pro vyhledávání: '"B. Guglielmi"'
Autor:
Raffaella Cincinelli, Loana Musso, Roberto Artali, Mario B Guglielmi, Ilaria La Porta, Carmela Melito, Fabiana Colelli, Francesco Cardile, Giacomo Signorino, Alessandra Fucci, Martina Frusciante, Claudio Pisano, Sabrina Dallavalle
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205018 (2018)
Recent studies have shown that HDAC inhibitors act synergistically with camptothecin derivatives in combination therapies. To exploit this synergy, new hybrid molecules targeting simultaneously topoisomerase I and HDAC were designed. In particular, a
Externí odkaz:
https://doaj.org/article/7ce7af2e26c944d4b632fbf5e3050b12
Autor:
Alessandra Fucci, Claudio Pisano, Egildo Luca D'Andrea, Sabrina Dallavalle, Silvia Gervasoni, Francesco Cardile, Fabiana Colelli, Mario B. Guglielmi, Nadine Darwiche, Giacomo Signorino, Ilaria La Porta, Giulio Vistoli, Raffaella Cincinelli, Loana Musso
Publikováno v:
Bioorganic chemistry. 104
Atypical retinoids (AR) or retinoid-related molecules (RRMs) represent a promising class of antitumor compounds. Among AR, E-3-(3'-adamantan-1-yl-4'-hydroxybiphenyl-4-yl)acrylic acid (adarotene), has been extensively investigated. In the present work
Autor:
Loana Musso, Claudio Pisano, Federica Prosperi, Fabiana Colelli, Maddalena Pizzulo, Sabrina Dallavalle, Giacomo Signorino, Elisa Modica, Nadine Darwiche, Egildo Luca D'Andrea, Ilaria La Porta, Raffaella Cincinelli, Silvia Gervasoni, Giulio Vistoli, Francesco Cardile, Alessandra Fucci, Assunta Riccio, Mario B. Guglielmi
Publikováno v:
European Journal of Medicinal Chemistry. 228:113971
Hybrid molecules targeting simultaneously DNA polymerase α (POLA1) and histone deacetylases (HDACs) were designed and synthesized to exploit a potential synergy of action. Among a library of screened molecules, MIR002 and GEM144 showed antiprolifera
Autor:
Carolina Pasero, Arianna Mancini, Mario B. Guglielmi, Giuseppina I. Truglio, Davide Deodato, Daniela Visaggio, Maurizio Botta, Teresa Ferraro, Filomena Sannio, Filomena De Luca, Ilaria D'Agostino, Rosita Del Prete, Claudio Zamperini, Jean Denis Docquier, Paolo Visca
Publikováno v:
Journal of medicinal chemistry. 61(20)
Nowadays, the increasing of multidrug-resistant pathogenic bacteria represents a serious threat to public health, and the lack of new antibiotics is becoming a global emergency. Therefore, research in antibacterial fields is urgently needed to expand
Autor:
Alvise Berti, Giulio Cavalli, B. Guglielmi, Elena Baldissera, M.G. Sabbadini, Corrado Campochiaro, Stefano Franchini, Lorenzo Dagna, Patrizia Aiello
Publikováno v:
Scandinavian Journal of Rheumatology. 44:309-314
To describe the efficacy and safety of different biological agents in a large cohort of 20 patients with adult-onset Still's disease (AOSD).We retrospectively evaluated 20 patients with severe or refractory AOSD treated with at least one biological a
Autor:
B. Guglielmi, Alessandro Tomelleri, Giulio Cavalli, Alvise Berti, Corrado Campochiaro, Roberto Nicoletti, Andrea Panzacchi, Riccardo Biavasco, Lorenzo Dagna, Marina Ferrarini
Publikováno v:
OncoImmunology, Vol 6, Iss 6 (2017)
Treatment of ErdheimâChester disease (ECD), a rare non-Langerhans histiocytosis, relies on interferon-α, chemotherapeutic agents such as purine analogs, cytokine-blocking agents and BRAF inhibitors. Since interleukin (IL)-6 levels are elevate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba80861394ec163d316a6de51ff15dc1
https://www.tandfonline.com/doi/full/10.1080/2162402X.2017.1318237
https://www.tandfonline.com/doi/full/10.1080/2162402X.2017.1318237
Autor:
F. Prosperi, A. Fucci, M. Pizzulo, I.L. Porta, E.L. D'Andrea, Mario B. Guglielmi, S. Penco, F. Colelli, A. Riccio, G. Signorino, L. Focareta, C. Pisano, R. Cincinelli, F. Cardile, Sabrina Dallavalle, L. Merlini, N. Darwiche
Publikováno v:
Cancer Research. 79:3096-3096
Small molecule modulators of chromatin modifying enzymes became the focus of drug discovery efforts, because of their direct antitumor effects, such as apoptosis and cell-cycle arrest, in addition to their indirect immunomodulation properties (Peedic
Autor:
Claudio Doglioni, Corrado Campochiaro, Lorenzo Dagna, B. Guglielmi, Simonetta Gerevini, Maria Grazia Sabbadini, Alvise Berti, Giulio Cavalli
Juvenile temporal arteritis is a rare inflammatory disease of the temporal arteries that affects young adults. The clinical course is benign and the surgical excision of the affected artery is usually curative. Here we report a case of bilateral juve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5169caf986531b014c17dafd65ea47
Autor:
Ilaria La Porta, Carmela Melito, Sabrina Dallavalle, Mario B. Guglielmi, Francesco Cardile, Martina Frusciante, Alessandra Fucci, Loana Musso, Giacomo Signorino, Raffaella Cincinelli, Roberto Artali, Fabiana Colelli, Claudio Pisano
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 10, p e0205018 (2018)
PLoS ONE, Vol 13, Iss 10, p e0205018 (2018)
Recent studies have shown that HDAC inhibitors act synergistically with camptothecin derivatives in combination therapies. To exploit this synergy, new hybrid molecules targeting simultaneously topoisomerase I and HDAC were designed. In particular, a
Autor:
Lucio Merlini, Giacomo Signorino, Mario B. Guglielmi, Nadine Darwiche, Sergio Penco, Claudio Pisano, Egildo Luca D'Andrea, Gabriele De Rubis, Ilaria La Porta, Fabiana Colelli, Raffaella Cincinelli, Sabrina Dallavalle, Alessandra Fucci, Francesco Cardile
Publikováno v:
Cancer Research. 78:4848-4848
The anti-proliferative and pro-apoptotic effects of Retinoid-Related Molecules (RRMs) are described as independent from Retinoids' receptors-mediated transcriptional activity. Prototypes of this class are CD437 and its more potent analogue ST1926, wh