Výsledky vyhledávání - "B. G. Heerdt"

Effects of fatty acids on expression of genes encoding subunits of cytochrome c oxidase and cytochrome c oxidase activity in HT29 human colonic adenocarcinoma cells

Autor: B G Heerdt, Leonard H. Augenlicht

Publikováno v: Journal of Biological Chemistry. 266:19120-19126

As the primary and preferred energy source of normal colonic epithelial cells, fatty acids may play a unique role in the differentiation and physiology of these cells. We have shown that expression levels of COXIII, a mitochondrial gene encoding one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c159083cabb79011054409083fb09a5
https://doi.org/10.1016/s0021-9258(18)55181-4

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Dissociation of staurosporine-induced apoptosis from G2-M arrest in SW620 human colonic carcinoma cells: initiation of the apoptotic cascade is associated with elevation of the mitochondrial membrane potential (deltapsim)

Autor: B G, Heerdt, M A, Houston, J M, Mariadason, L H, Augenlicht

Publikováno v: Cancer research. 60(23)

We have identified an alternative apoptotic cascade induced in SW620 human colonic carcinoma cells by the protein kinase antagonist staurosporine (stsp). Consistent with its effect in other colonic epithelial cells, stsp induced G2-M arrest and apopt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7b26ec35026d348108c5a94607fef14
https://pubmed.ncbi.nlm.nih.gov/11118056

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Short-chain fatty acid metabolism, apoptosis, and Apc-initiated tumorigenesis in the mouse gastrointestinal mucosa

Autor: L H, Augenlicht, G M, Anthony, T L, Church, W, Edelmann, R, Kucherlapati, K, Yang, M, Lipkin, B G, Heerdt

Publikováno v: Cancer research. 59(23)

Short-chain fatty acids (SCFAs) are physiological regulators of growth and differentiation in the gastrointestinal tract, and we have previously shown that apoptosis induced in colonic cell lines by these compounds is dependent on their metabolism by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::714ce3a688702cb3b572c99ce2c5eefc
https://pubmed.ncbi.nlm.nih.gov/10606249

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Butyrate-induced apoptotic cascade in colonic carcinoma cells: modulation of the beta-catenin-Tcf pathway and concordance with effects of sulindac and trichostatin A but not curcumin

Autor: M, Bordonaro, J M, Mariadason, F, Aslam, B G, Heerdt, L H, Augenlicht

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 10(10)

Short-chain fatty acids play a critical role in colonic homeostasis because they stimulate pathways of growth arrest, differentiation, and apoptosis. These effects have been well characterized in colonic cell lines in vitro. We investigated the role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0bf1881ba947cd23260e36ab3d7ec63b
https://pubmed.ncbi.nlm.nih.gov/10547075

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Initiation of growth arrest and apoptosis of MCF-7 mammary carcinoma cells by tributyrin, a triglyceride analogue of the short-chain fatty acid butyrate, is associated with mitochondrial activity

Autor: B G, Heerdt, M A, Houston, G M, Anthony, L H, Augenlicht

Publikováno v: Cancer research. 59(7)

We investigated the effects of tributyrin, a triglyceride analogue of the short-chain fatty acid butyrate and an approved food additive, establishing induction of growth arrest and apoptosis of MCF-7 human mammary carcinoma cells. Transient increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bef2262e1cdf98c2488927a5b46b1e8a
https://pubmed.ncbi.nlm.nih.gov/10197633

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Mitochondrial membrane potential (delta psi(mt)) in the coordination of p53-independent proliferation and apoptosis pathways in human colonic carcinoma cells

Autor: B G, Heerdt, M A, Houston, G M, Anthony, L H, Augenlicht

Publikováno v: Cancer research. 58(13)

We have previously defined depressed mitochondrial function as a determinant in colon cancer risk and progression and established that metabolism of butyrate, a short-chain fatty acid generated during the fermentation of fiber by endogenous intestina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::56e749705b8ba6f0d71960cf313dfbc4
https://pubmed.ncbi.nlm.nih.gov/9661904

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Combination therapy with 5-fluorouracil and IFN-alpha2a induces a nonrandom increase in DNA fragments of less than 3 megabases in HT29 colon carcinoma cells

Autor: R W, Horowitz, B G, Heerdt, X, Hu, E L, Schwartz, S, Wadler

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 3(8)

We have used pulsed-field gel electrophoresis to examine 5-fluorouracil (5FU)-induced DNA double-strand breaks (DSBs), both with and without modulation by IFN-alpha2a (IFNalpha), in HT29 human colon adenocarcinoma cells. Although 24-h treatment with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a1211a4ebf3ab49b871c25909b2e955d
https://pubmed.ncbi.nlm.nih.gov/9815814

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Short-chain fatty acid-initiated cell cycle arrest and apoptosis of colonic epithelial cells is linked to mitochondrial function

Autor: B G, Heerdt, M A, Houston, L H, Augenlicht

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 8(5)

Butyrate, a short-chain fatty acid produced during microbial fermentation of fiber, induces growth arrest, differentiation, and apoptosis of colonic epithelial cells in vitro, and our prior work has shown that this induction is tightly linked to mito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eb05f5be5c251bef4572dd45c8ed9dd3
https://pubmed.ncbi.nlm.nih.gov/9149903

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Low-level c-myc amplification in human colonic carcinoma cell lines and tumors: a frequent, p53-independent mutation associated with improved outcome in a randomized multi-institutional trial

Autor: L H, Augenlicht, S, Wadler, G, Corner, C, Richards, L, Ryan, A S, Multani, S, Pathak, A, Benson, D, Haller, B G, Heerdt

Publikováno v: Cancer research. 57(9)

Human colonic cancer is associated with multiple genetic deletions, mutations, and alterations in gene expression; in contrast, gene amplification has not been recognized as a prominent characteristic of human colonic tumors. Although the c-myc gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0c17d00f2f63a96ba7d9fe2fff70e9c4
https://pubmed.ncbi.nlm.nih.gov/9135021

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Steady-state levels of mitochondrial messenger RNA species characterize a predominant pathway culminating in apoptosis and shedding of HT29 human colonic carcinoma cells

Autor: B G, Heerdt, M A, Houston, J J, Rediske, L H, Augenlicht

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 7(1)

A differentiated human colonic epithelial cell has undergone relatively stable molecular, biochemical, and cellular alterations resulting in the acquisition of structures, activities, and functions that characterize it as one of at least three mature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::33845b98248be8344a246aadfc6af1fb
https://pubmed.ncbi.nlm.nih.gov/8788038

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