Figure S4 from Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer–Associated R438W DNA Polymerase Lambda Protein

Autor: Joann B. Sweasy, David P. Tuck, Joanne B. Weidhaas, Vincent Schulz, B. Frazier Taylor, Jamie B. Towle-Weicksel, Korie B. Bush, Antonia A. Nemec

Treatment with estrogen does not affect cellular proliferation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421d38e4ec04fcea2b5942a0728ccd87
https://doi.org/10.1158/1541-7786.22514728.v1

Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-associated R438W DNA Polymerase Lambda Protein

Autor: Joann B. Sweasy, Korie B. Bush, B. Frazier Taylor, Jamie B. Towle-Weicksel, Antonia A. Nemec, David Tuck, Vincent P. Schulz, Joanne B. Weidhaas

Publikováno v: Molecular cancer research : MCR, vol 14, iss 11
Nemec, AA; Bush, KB; Towle-Weicksel, JB; Taylor, BF; Schulz, V; Weidhaas, JB; et al.(2016). Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein. MOLECULAR CANCER RESEARCH, 14(11), 1068-1077. doi: 10.1158/1541-7786.MCR-16-0209. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2c40g7v0

Repair of DNA damage is critical for maintaining the genomic integrity of cells. DNA polymerase lambda (POLL/Pol λ) is suggested to function in base excision repair (BER) and nonhomologous end-joining (NHEJ), and is likely to play a role in damage t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48525871ff5bb485768a41c105281c2c
https://europepmc.org/articles/PMC5107123/

Exit from Arsenite-Induced Mitotic Arrest Is p53 Dependent

Autor: Samuel C. McNeely, Xiaogiang Xu, J. Christopher States, Wolfgang Zacharias, Michael J. McCabe, B. Frazier Taylor

Publikováno v: Environmental Health Perspectives

Background Arsenic is both a human carcinogen and a chemotherapeutic agent, but the mechanism of neither arsenic-induced carcinogenesis nor tumor selective cytotoxicity is clear. Using a model cell line in which p53 expression is regulated exogenousl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4899d5037f237c76b61900139528fde8
https://doi.org/10.1289/ehp.8969

Evidence-Based Cardiovascular Management of Patients Receiving Radiotherapy to the Heart

Autor: B. Frazier Taylor, Kenneth B. Roberts, Suzanne B. Evans

Publikováno v: Evidence-Based Cardiology Consult ISBN: 9781447144403

Historic and modern oncologic therapy techniques have the potential to adversely affect cardiovascular function. Depending on the disease, cancer therapy often requires radiotherapy (RT) to the chest, cardiotoxic chemotherapy, or both. A history of (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8b698592326ab923c62dcad627b183b
https://doi.org/10.1007/978-1-4471-4441-0_28

Sensitivity to sodium arsenite in human melanoma cells depends upon susceptibility to arsenite-induced mitotic arrest

Autor: Teresa W.-M. Fan, B. Frazier Taylor, Michael J. McCabe, Allan R. Pinhas, Alex C. Belshoff, Samuel C. McNeely, J. Christopher States

Publikováno v: Toxicology and applied pharmacology. 229(2)

Arsenic induces clinical remission in patients with acute promyelocytic leukemia and has potential for treatment of other cancers. The current study examines factors influencing sensitivity to arsenic using human malignant melanoma cell lines. A375 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292f759b52fac5c9096dcbf3cf7d69c7
https://pubmed.ncbi.nlm.nih.gov/18328521