Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis

Autor: Magdalena B. Flak, Romain A. Colas, Estefanía Muñoz-Atienza, Michael A. Curtis, Jesmond Dalli, Costantino Pitzalis

Publikováno v: JCI Insight, Vol 7, Iss 20 (2022)

Externí odkaz: https://doaj.org/article/c25f1dd08a2e46df9119ab889fa07571

Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation

Autor: Magdalena B. Flak, Duco S. Koenis, Maria Gonzalez-Nunez, Ana Chopo-Pizarro, Jesmond Dalli

Publikováno v: Biochemical pharmacology. 207

We recently found that the G protein coupled receptor GPR101 mediates the phagocyte-directed pro-resolving activities of RvD5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e598863d923d510e808690ec6275750
https://pubmed.ncbi.nlm.nih.gov/36400250

Molecular cloning and functional expression of the K + channel K V 7.1 and the regulatory subunit KCNE1 from equine myocardium

Autor: Michael S. DePriest, Dagmar S Trachsel, Kirstine Calloe, Frank Hauser, Theodore S. Kalbfleisch, Maria de los Angeles Tejada, James N. MacLeod, Philip J. Pedersen, Kirsten B. Thomsen, Rikke Buhl, Jon B. Flak, Dan A. Klaerke

Publikováno v: Research in Veterinary Science

Background The voltage-gated K + -channel K V 7.1 and the subunit KCNE1, encoded by the KCNQ1 and KCNE1 genes, respectively, are responsible for termination of the cardiac action potential. In humans, mutations in these genes can predispose patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e301c4e4a445d8613c8000820bb3d1aa
https://doi.org/10.1016/j.rvsc.2017.09.010

GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections

Autor: Jesmond Dalli, Magdalena B. Flak, James M. Smith, Francesco Palmas, Agua Sobrino, Duco S. Koenis, Kimberly Pistorius

Publikováno v: The Journal of Clinical Investigation
Flak, M B, Koenis, D S, Sobrino, A, Smith, J, Pistorius, K, Palmas, F & Dalli, J 2020, ' GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections ', The Journal of clinical investigation, vol. 130, no. 1, pp. 359-373 . https://doi.org/10.1172/JCI131609
Journal of Clinical Investigation

N-3 docosapentaenoic acid-derived resolvin D5 (RvD5n-3 DPA) is diurnally regulated in peripheral blood and exerts tissue-protective actions during inflammatory arthritis. Here, using an orphan GPCR screening approach coupled with functional readouts,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbe0452bffdbb24b0ed4a7718048d9e
https://pubmed.ncbi.nlm.nih.gov/31793912

Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis

Autor: Richard S. Blumberg, Gwenny M. Fuhler, Jonathan W. Ashcroft, Lukas Niederreiter, Stephan R. Targan, David Ron, Joya Bhattacharyya, C. Janneke van der Woude, Magdalena B. Flak, Kenji Kohno, Svetlana Saveljeva, Maikel P. Peppelenbosch, Andrew Smith, Timon E. Adolph, Heather P. Harding, Richa Bharti, Markus Tschurtschenthaler, Takao Iwawaki, Arthur Kaser, David Q. Shih, Philip Rosenstiel, Miles Parkes

Publikováno v: Journal of Experimental Medicine, 214(2), 401-422. Rockefeller University Press
The Journal of Experimental Medicine

Tschurtschenthaler et al. report a Crohn’s disease–like ileitis mediated by IRE1α that develops in mice with intestinal-epithelial Atg16l1 deletion when they age. The authors propose a selective autophagy process involved in the removal of IRE1�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ef82c725655eff0da1d05e5c971645
https://www.repository.cam.ac.uk/handle/1810/262915