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Quantitative analysis of adenine nucleotides during the prelytic phase of cell death mediated by C5b-9

Autor: J C Papadimitriou, L E Ramm, C B Drachenberg, B F Trump, M L Shin

Publikováno v: The Journal of Immunology. 147:212-217

The nucleated cell death mediated by C5b-9 depends on the extent of C fixation and parameters that affect the ability of the cell to eliminate C5b-9. When C5b-9 formation exceeds elimination, cell death can be initiated. High Ca2+ in the medium accel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cdaa2f86b3fae274543bb99e468aa51
https://doi.org/10.4049/jimmunol.147.1.212

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Cytotoxic effects of eosinophils on renal proximal tubular epithelial cells: implications for renal allograft rejection

Autor: H R, Makhlouf, C B, Drachenberg, A, Trifillis, B F, Trump, J C, Papadimitriou

Publikováno v: Journal of submicroscopic cytology and pathology. 31(4)

Eosinophils are inflammatory cells that actively participate in the defense against large, multicellular parasites. Eosinophils are also a prominent component in the inflammatory infiltrates seen in acute allograft rejection. Their role in that proce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cfcdcbf03d251afe71a612b396c29087
https://pubmed.ncbi.nlm.nih.gov/10685394

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bcl-2 enhancement of malignant transformation in mouse epidermal JB6 cells

Autor: P A, Amstad, H, Liu, M, Ichimiya, S, Chang, I K, Berezesky, B F, Trump

Publikováno v: Molecular carcinogenesis. 20(2)

Increased bcl-2 expression is a common feature of many types of human malignancies, which implies that bcl-2 plays an important role in tumorigenesis. To better understand the molecular mechanisms of bcl-2-induced oncogenesis, we examined the effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1f69691c3ebc0af89408575b07e8814
https://pubmed.ncbi.nlm.nih.gov/9364213

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Interaction between cytolytic T-cells and immobilized renal tubular epithelial cells: evidence of polarity on both effector and target cells

Autor: J C, Papadimitriou, C B, Drachenberg, G A, Hadley, S T, Bartlett, B F, Trump

Publikováno v: Journal of submicroscopic cytology and pathology. 29(3)

The mode by which cytolytic T-lymphocytes (CTL) deliver the lethal hit to their targets has been studied extensively. The CTL exhibits a characteristic polarization, with the attacking end formed by the uropod (containing the Golgi complex and associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9064ddb8e6c03e8b3708ebaecf0bc93
https://pubmed.ncbi.nlm.nih.gov/9267046

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Tamoxifen induces deregulation of [Ca2+] in human breast cancer cells

Autor: P T, Jain, B F, Trump

Publikováno v: Anticancer research. 17(2A)

Tamoxifen is a clinically useful estrogen antagonist at or below 10(-6) M concentration. However, above this concentration tamoxifen exerts non-ER mediated cytotoxicity. Such cytotoxic effects are lethal or sublethal. The lethal effects lead to cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::78cfd2eb0b7d8f2627f1acc4366b5c3e
https://pubmed.ncbi.nlm.nih.gov/9137466

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Differential sensitivity of normal and H-ras oncogene-transformed rat kidney epithelial cells to okadaic acid-induced apoptosis

Autor: M A, Davis, S H, Chang, B F, Trump

Publikováno v: Toxicology and applied pharmacology. 141(1)

H-ras oncogenes have been identified in greater than 50% of the most common forms of human neoplasia. Ras-related proteins have been postulated to mediated signal transduction pathways involving mitogen-activated protein (MAP) kinases and nuclear res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37cc62131c94857dc86441e3e7f579b0
https://pubmed.ncbi.nlm.nih.gov/8917680

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The mechanisms of calcium-mediated cell injury and cell death [correcgted]

Autor: B F, Trump, I K, Berezesky

Publikováno v: New horizons (Baltimore, Md.). 4(1)

It has been known for some time that all pathophysiologic changes in shock and trauma have their basis at the cellular and molecular levels. These changes have been and continue to be studied in vivo in human patients and animal models and in vitro u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::762f8c9835b09d3c2ac0e82c45162e31
https://pubmed.ncbi.nlm.nih.gov/8689270

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