Výsledky vyhledávání

Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase: evidence for cytotoxic mechanisms different from inhibition of protein synthesis

Autor: M S, Iordanov, O P, Ryabinina, J, Wong, T H, Dinh, D L, Newton, S M, Rybak, B E, Magun

Publikováno v: Cancer research. 60(7)

Cytotoxic endoribonucleases (RNases) possess a potential for use in cancer therapy. However, the molecular determinants of RNase-induced cell death are not well understood. In this work, we identify such determinants of the cytotoxicity induced by on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12ee7657dfd5d543a632319729db7dfa
https://pubmed.ncbi.nlm.nih.gov/10766189

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Loss of cellular K+ mimics ribotoxic stress. Inhibition of protein synthesis and activation of the stress kinases SEK1/MKK4, stress-activated protein kinase/c-Jun NH2-terminal kinase 1, and p38/HOG1 by palytoxin

Autor: M S, Iordanov, B E, Magun

Publikováno v: The Journal of biological chemistry. 273(6)

The tumor promoter palytoxin has been found to activate the stress-activated protein kinase/c-Jun NH2-terminal kinase 1 (SAPK/JNK1), and it also potentiates, as demonstrated here, the p38/HOG1 mitogen-activated protein kinase and the upstream activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6cbd9d16ae43e5a53fb6a286724a1636
https://pubmed.ncbi.nlm.nih.gov/9452478

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Transient inhibition of protein synthesis induces the immediate early gene VL30: alternative mechanism for thapsigargin-induced gene expression

Autor: B E, Magun, K D, Rodland

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 6(7)

Induction of gene expression in response to calcium ionophores or thapsigargin, which inhibits the calcium-ATPase responsible for sequestering intracellular calcium, has frequently been attributed to direct stimulatory events subsequent to the elevat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d56bcbe8c6fe2389693fb01d32770d98
https://pubmed.ncbi.nlm.nih.gov/7547511

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The role of C-Fos in growth factor regulation of stromelysin/transin gene expression

Autor: L D, Kerr, B E, Magun, L M, Matrisian

Publikováno v: Matrix (Stuttgart, Germany). Supplement. 1

Expression of the rat stromelysin (transin) gene is stimulated by growth factors such as epidermal growth factor (EGF) and platelet-derived growth factor (PDGF), and inhibited by transforming growth factor-beta (TGF beta). Stimulation by both EGF and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4260c1b3967a0570eeef0db28b6b4492
https://pubmed.ncbi.nlm.nih.gov/1480019

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Modulation of RNA expression by intracellular calcium. Existence of a threshold calcium concentration for induction of VL30 RNA by epidermal growth factor, endothelin, and protein kinase C

Autor: K D, Rodland, L L, Muldoon, P, Lenormand, B E, Magun

Publikováno v: The Journal of biological chemistry. 265(19)

We investigated the role of intracellular [Ca2+] in mediating the independent signal transduction pathways leading to induction of VL30 RNA expression by multiple agonists in the Rat-1-derived RVL-3 cell line. This cell line contains a single integra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ced34f99e2f5471a9fb1535c0cf92c4
https://pubmed.ncbi.nlm.nih.gov/2113528

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Prolactin receptors on human T and B lymphocytes: antagonism of prolactin binding by cyclosporine

Autor: D H Russell, R Kibler, L Matrisian, D F Larson, B Poulos, B E Magun

Publikováno v: The Journal of Immunology. 134:3027-3031

Prolactin (PRL) receptors have been identified recently on human peripheral blood mononuclear cells (MNC) and may be involved in the regulation of cell-mediated immunity. Cyclosporine (CsA), an immunosuppressive cyclic endecapeptide utilized to prolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ee8d86668055cf2099dd6942f1eae34
https://doi.org/10.4049/jimmunol.134.5.3027

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Phosphorylation of nuclear and DNA-binding proteins in proliferating and quiescent mammalian cells

Autor: B E Magun, M Costa, Eugene W. Gerner, D K Holmes

Publikováno v: Biochemical Journal. 194:193-207

The dependence of cell proliferation on nuclear protein phosphorylation was studied with exponential-phase and stationary-phase cultures of Chinese-hamster ovary cells. Nuclear proteins were fractionated, according to their DNA-binding affinities, by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b5d3a373a579f140bab77499942bfa
https://doi.org/10.1042/bj1940193

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Individual mouse VL30 elements transferred to rat cells by viral pseudotypes retain their responsiveness to activators of protein kinase C

Autor: A. M. C. Brown, B. E. Magun, K. D. Rodland

Publikováno v: Molecular and Cellular Biology. 7:2296-2298

By exploiting the retroviral characteristics of mouse VL30 elements, we transferred individual copies of VL30 to Rat-1 cells by infection. Analysis of clonal isolates containing single VL30 elements integrated into the Rat-1 genome indicates that res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a93e619a080aefc97330baf590d8787b
https://doi.org/10.1128/mcb.7.6.2296

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Stimulation of phosphatidylinositol hydrolysis, diacylglycerol release, and gene expression in response to endothelin, a potent new agonist for fibroblasts and smooth muscle cells

Autor: L L, Muldoon, K D, Rodland, M L, Forsythe, B E, Magun

Publikováno v: The Journal of biological chemistry. 264(15)

Endothelin is a potent vasoconstrictive peptide recently isolated by Yanagisawa, M., Kurihara, H., Kimura, S., Tamobe, Y., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K., and Masaki, T. (1988) Nature 332, 411-415). In order to understand the mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ab7b7ad78fdd144a4c2a4306b65c90fa
https://pubmed.ncbi.nlm.nih.gov/2656683

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