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Akademický článek

Clinical findings and outcome in feline tetanus: a multicentric retrospective study of 27 cases and review of the literature

Autor: Alice Dussaux, Laurent Fuhrer, Martin B. Dorner, Koen Santifort, An Vanhaesebrouck, Marika Menchetti, Cecilia-Gabriella Danciu, Guillaume Dutil, Catherine Escriou, Stephane Blot, Sarah Gutmann, Carina Taestensen, Vincent Mayousse

Publikováno v: Frontiers in Veterinary Science, Vol 11 (2024)

Tetanus is a toxigenic illness caused by the action of Clostridium tetani neurotoxin (TeNT), which results in partial or generalized muscle stiffness in infected mammals and birds. The disease is rarely reported in cats due to their innate resistance

Externí odkaz: https://doaj.org/article/7faa218e4e854d6a956952d164357b18

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Akademický článek

A bead-based multiplex assay covering all coronaviruses pathogenic for humans for sensitive and specific surveillance of SARS-CoV-2 humoral immunity

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)

Abstract Serological assays measuring antibodies against SARS-CoV-2 are key to describe the epidemiology, pathobiology or induction of immunity after infection or vaccination. Of those, multiplex assays targeting multiple antigens are especially help

Externí odkaz: https://doaj.org/article/6e307ba568f44985978afb78e5c381cc

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Akademický článek

Vaccine-induced neutralizing antibodies bind to the H protein of a historical measles virus

Autor: Anne Zemella, Kerstin Beer, Franziska Ramm, Dana Wenzel, Ariane Düx, Kevin Merkel, Sebastien Calvignac-Spencer, Daniel Stern, Martin B. Dorner, Brigitte G. Dorner, Navena Widulin, Thomas Schnalke, Cornelia Walter, Anne Wolbert, Bernhard G. Schmid, Annette Mankertz, Sabine Santibanez

Publikováno v: International Journal of Medical Microbiology, Vol 314, Iss , Pp 151607- (2024)

Measles is a highly contagious airborne viral disease. It can lead to serious complications and death and is preventable by vaccination. The live-attenuated measles vaccine (LAMV) derived from a measles virus (MV) isolated in 1954 has been in use glo

Externí odkaz: https://doaj.org/article/a8672cb3b85e473f936d7711a30fe5e2

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Akademický článek

A Novel Prophage-like Insertion Element within yabG Triggers Early Entry into Sporulation in Clostridium botulinum

Autor: François P. Douillard, Inês Martins Portinha, Yağmur Derman, Cédric Woudstra, Tommi Mäklin, Martin B. Dorner, Hannu Korkeala, Adriano O. Henriques, Miia Lindström

Publikováno v: Viruses, Vol 15, Iss 12, p 2431 (2023)

Sporulation is a finely regulated morphogenetic program important in the ecology and epidemiology of Clostridium botulinum. Exogenous elements disrupting sporulation-associated genes contribute to sporulation regulation and introduce diversity in the

Externí odkaz: https://doaj.org/article/561ef2e3f4704224b01857a3548a23f1

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Akademický článek

Construction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid

Autor: Maria B. Nowakowska, Katja Selby, Adina Przykopanski, Maren Krüger, Nadja Krez, Brigitte G. Dorner, Martin B. Dorner, Rongsheng Jin, Nigel P. Minton, Andreas Rummel, Miia Lindström

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract Botulinum neurotoxins (BoNTs), produced by the spore-forming bacterium Clostridium botulinum, cause botulism, a rare but fatal illness affecting humans and animals. Despite causing a life-threatening disease, BoNT is a multipurpose therapeut

Externí odkaz: https://doaj.org/article/be0f4d591b8f4c348fccdcb1b12a3fa8

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Akademický článek

Genomic and Phenotypic Characterization of Clostridium botulinum Isolates from an Infant Botulism Case Suggests Adaptation Signatures to the Gut

Autor: François P. Douillard, Yağmur Derman, Cédric Woudstra, Katja Selby, Tommi Mäklin, Martin B. Dorner, Harri Saxén, Brigitte G. Dorner, Hannu Korkeala, Miia Lindström

Publikováno v: mBio, Vol 13, Iss 3 (2022)

ABSTRACT In early life, the immature human gut microbiota is prone to colonization by pathogens that are usually outcompeted by mature microbiota in the adult gut. Colonization and neurotoxin production by a vegetative Clostridium botulinum culture i

Externí odkaz: https://doaj.org/article/da2ef2ec3d6a4050b57db1f8a7a5db35

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Akademický článek

Strengthening the United Nations Secretary-General’s Mechanism to an alleged use of bioweapons through a quality-assured laboratory response

Autor: Sandra Appelt, Anna-Maria Rohleder, Cédric Invernizzi, Robert Mikulak, Annika Brinkmann, Andreas Nitsche, Maren Krüger, Martin B. Dorner, Brigitte G. Dorner, Holger C. Scholz, Roland Grunow

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-4 (2021)

The cascade of innovations in biotechnology opens new pathways for biological warfare. The international laboratory network being developed under the UN Secretary-General’s Mechanism could provide vital evidence in case of an alleged biological att

Externí odkaz: https://doaj.org/article/e1d767518f294743a517442751b713ec

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Akademický článek

Selection and Development of Nontoxic Nonproteolytic Clostridium botulinum Surrogate Strains for Food Challenge Testing

Autor: Marijke Poortmans, Kristof Vanoirbeek, Martin B. Dorner, Chris W. Michiels

Publikováno v: Foods, Vol 11, Iss 11, p 1577 (2022)

Clostridium botulinum causes severe foodborne intoxications by producing a potent neurotoxin. Challenge studies with this pathogen are an important tool to ensure the safety of new processing techniques and newly designed or modified foods, but they

Externí odkaz: https://doaj.org/article/2f7f10c542cb4f3f81eef7649e81f57f

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