Zobrazeno 1 - 10
of 100
pro vyhledávání: '"B. Doak"'
Autor:
Karol Nass, Lars Redecke, M. Perbandt, O. Yefanov, M. Klinge, R. Koopmann, F. Stellato, A. Gabdulkhakov, R. Schönherr, D. Rehders, J. M. Lahey-Rudolph, A. Aquila, A. Barty, S. Basu, R. B. Doak, R. Duden, M. Frank, R. Fromme, S. Kassemeyer, G. Katona, R. Kirian, H. Liu, I. Majoul, J. M. Martin-Garcia, M. Messerschmidt, R. L. Shoeman, U. Weierstall, S. Westenhoff, T. A. White, G. J. Williams, C. H. Yoon, N. Zatsepin, P. Fromme, M. Duszenko, H. N. Chapman, C. Betzel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Trypanosoma brucei inosine-5′-monophosphate dehydrogenase (IMPDH) is an enzyme in the guanine nucleotide biosynthesis pathway and of interest as a drug target. Here the authors present the 2.8 Å room temperature structure of TbIMPDH determined by
Externí odkaz:
https://doaj.org/article/62386f11dbb14a64b2304040fafe13d2
Autor:
L. Galli, S.-K. Son, M. Klinge, S. Bajt, A. Barty, R. Bean, C. Betzel, K. R. Beyerlein, C. Caleman, R. B. Doak, M. Duszenko, H. Fleckenstein, C. Gati, B. Hunt, R. A. Kirian, M. Liang, M. H. Nanao, K. Nass, D. Oberthür, L. Redecke, R. Shoeman, F. Stellato, C. H. Yoon, T. A. White, O. Yefanov, J. Spence, H. N. Chapman
Publikováno v:
Structural Dynamics, Vol 2, Iss 4, Pp 041703-041703-8 (2015)
Current hard X-ray free-electron laser (XFEL) sources can deliver doses to biological macromolecules well exceeding 1 GGy, in timescales of a few tens of femtoseconds. During the pulse, photoionization can reach the point of saturation in which c
Externí odkaz:
https://doaj.org/article/98de9c6dd27d4e1dbb6396e48ef9fce7
Autor:
Dan E. Wilson, Tashina Van Vlack, Brendin P. Schievink, Eric B. Doak, Jason S. Shane, Elizabeth Dean
Publikováno v:
International Journal of Hypertension, Vol 2014 (2014)
Established standards for first-line hypertension management include lifestyle modification and behavior change. The degree to which and how lifestyle modification is systematically integrated into studies of first-line drug management for hypertensi
Externí odkaz:
https://doaj.org/article/7658f60c106d4f9c95bc184d46746e1d
Autor:
Garth J. Williams, Gergely Katona, J.M. Lahey-Rudolph, Stephan Kassemeyer, O. Yefanov, M. Perbandt, Chun Hong Yoon, Jose M. Martin-Garcia, Sebastian Westenhoff, Lars Redecke, M. Klinge, Marc Messerschmidt, Henry N. Chapman, Rainer Duden, Francesco Stellato, Anton Barty, Azat Gabdulkhakov, M. Frank, Richard A. Kirian, Irina Majoul, Thomas A. White, C. Betzel, Robert L. Shoeman, Raimund Fromme, Karol Nass, A. Aquila, Nadia A. Zatsepin, Uwe Weierstall, Rudolf Koopmann, Haiguang Liu, Dirk Rehders, R. B. Doak, Petra Fromme, Michael Duszenko, Shibom Basu, R. Schonherr
Publikováno v:
Nature Communications 11(1), 620 (2020). doi:10.1038/s41467-020-14484-w
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Sleeping sickness is a fatal disease caused by the protozoan parasite Trypanosoma brucei (Tb). Inosine-5’-monophosphate dehydrogenase (IMPDH) has been proposed as a potential drug target, since it maintains the balance between guanylate deoxynucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c7c2b56df31ffdb828d9976649cbbb
https://bib-pubdb1.desy.de/record/435344
https://bib-pubdb1.desy.de/record/435344
Autor:
Eric B. Doak, Dan E. Wilson, Jason S. Shane, Elizabeth Dean, Tashina Van Vlack, Brendin P. Schievink
Publikováno v:
International Journal of Hypertension
International Journal of Hypertension, Vol 2014 (2014)
International Journal of Hypertension, Vol 2014 (2014)
Established standards for first-line hypertension management include lifestyle modification and behavior change. The degree to which and how lifestyle modification is systematically integrated into studies of first-line drug management for hypertensi
Autor:
Mark S. Hunter, Xiaoyu Wang, Uwe Weierstall, D. Starodub, Stefano Marchesini, David A. Shapiro, John C. H. Spence, Daniel P. DePonte, Richard A. Kirian, Petra Fromme, R. B. Doak
Publikováno v:
Biophysical journal 100, 198-206 (2011). doi:10.1016/j.bpj.2010.10.049
Membrane proteins constitute >30% of the proteins in an average cell, and yet the number of currently known structures of unique membrane proteins is
Autor:
John C. H. Spence, Stefano Marchesini, Daniel P. DePonte, Gary G. Hembree, R. B. Doak, Petra Fromme, Uwe Weierstall, David A. Shapiro, Henry N. Chapman, Mark S. Hunter, D. Starodub, Kevin Schmidt
Publikováno v:
Journal of Synchrotron Radiation. 15:593-599
Atomic-resolution structures from small proteins have recently been determined from high-quality powder diffraction patterns using a combination of stereochemical restraints and Rietveld refinement [Von Dreele (2007), J. Appl. Cryst. 40, 133-143; Mar
Publikováno v:
Journal of Physics D: Applied Physics. 39:930-936
Use of fused silica microcapillary tubing for supersonic molecular beam nozzles is reported. Speed ratio measurements were made with nozzles of various diameters and sidewall profiles, demonstrating that these nozzles perform as well as the best conv
Autor:
Petra Fromme, Jun Wu, Gary G. Hembree, Uwe Weierstall, Kevin Schmidt, John C. H. Spence, B. Doak
Publikováno v:
Acta Crystallographica Section A Foundations of Crystallography. 61:237-245
The effect of the limited alignment of hydrated molecules is considered in a laser-aligned molecular beam, on diffraction patterns taken from the beam. Simulated patterns for a protein beam are inverted using the Fienup-Gerchberg-Saxton phasing algor
Autor:
R B Doak
Publikováno v:
Journal of Physics: Condensed Matter. 16:S2863-S2878
An overly simplistic but nonetheless useful model is employed to explore basic attributes of field ionization detection. The base cross-sectional detection area of a field ionization tip is set by a centrifugal barrier: molecules impinging at too hig