Zobrazeno 1 - 10
of 241
pro vyhledávání: '"B. Desoize"'
Publikováno v:
European Journal of Cancer. 32:1734-1738
The aim of this study was to validate prospectively a model of cisplatin dose adjustment. 27 patients (63 courses) with lung cancer were treated by a 5 day continuous infusion of cisplatin and etoposide. The dose of cisplatin was adjusted in order to
Publikováno v:
Clinical Research and Regulatory Affairs. 11:257-268
A dose prediction method for cisplatin based on the Bayesian principle and with use of limited blood sampling is described. A reference population was used to establish plasma total platinum (Pt) pharmacokinetics. the limited sampling method, using t
Autor:
J. Robert, B. Desoize
Publikováno v:
European Journal of Cancer. 30:844-851
The dose of anticancer drugs is currently adjusted to the patient body surface area, although patients have different abilities to clear anticancer drugs. The dose adjustment to physiological functions permits major toxic accidents to be avoided. The
Publikováno v:
International journal of oncology. 5(1)
The retention of adriamycin in 5 Friend cell sublines of increasing degree of resistance was enhanced in vitro by three compounds: verapamil, nigericine and vanadate. Vanadate had the strongest activity, it enhanced also the incorporation in sensitiv
Autor:
B, Desoize
Publikováno v:
Critical reviews in oncology/hematology. 72(3)
Publikováno v:
Biomedicine & Pharmacotherapy. 45:203-207
Twenty-two pharmacokinetic studies were carried out in 11 patients receiving cisplatin (20 mg/m2 per d) associated with etoposide (50 mg/m2 per d), as 5-day continuous infusions, every 4 weeks. Blood was withdrawn at 8:30 am from day 1-5. Within 15 m
Autor:
B Desoize
Publikováno v:
Critical Reviews in Oncology/Hematology. 72:215-216
Publikováno v:
Anticancer research. 18(6A)
Cells cultured as spheroids present an heterogeneity similar to that of tumours in vivo. In the spheroid peripheral layers, cells are proliferating, deeper cells are non-cycling, when in the aggregate centre, cells form often a necrotic core. A multi
Autor:
B. Desoize
Publikováno v:
Critical Reviews in Oncology/Hematology. 64:208-209
Publikováno v:
Anti-cancer drug design. 13(7)
Some members of a series of 12-alkyloxy benzo[c]phenanthridines are potent inhibitors of the growth of P388 tumour cells in vitro, with a strong dependence on the nature of the 12-substituent. Analogues with a quaternary nitrogen in the side chain bi