Zobrazeno 1 - 10
of 89
pro vyhledávání: '"B. Dean Nelson"'
Autor:
Joseph W. DePierre, Mousumi Rahman Qazi, B. Dean Nelson, Moustapha Hassan, Manuchehr Abedi-Valugerdi
Publikováno v:
Toxicology Letters. 219:1-7
Exposure of mice to perfluorooctanoate (PFOA) evokes pronounced hepatomegaly along with significant alterations in both the histological structure and immune status of the liver. The present study was designed to evaluate the effects of this perfluor
Publikováno v:
Food and Chemical Toxicology. 50:2955-2963
It is well established that exposure of mice to perfluorooctanoate (PFOA) or perfluorooctane sulfonate (PFOS) exerts adverse effects on the thymus and spleen. Here, we characterize the effects of a 10-day dietary treatment with these compounds (0.001
Publikováno v:
Biochemical and Biophysical Research Communications. 411:648-653
We earlier reported the formation of a unique nuclear NF1/Smad complex in serum-restricted fibroblasts that acts as an NF1-dependent repressor of the human adenine nucleotide translocase-2 gene (ANT2) [K. Luciakova, G. Kollarovic, P. Barath, B.D. Nel
Autor:
Manuchehr Abedi-Valugerdi, B. Dean Nelson, Joseph W. DePierre, Dave J. Ehresman, Mousumi Rahman Qazi, Shu-Ching Chang, John L. Butenhoff, Zhenlei Xia, Jasna Bogdanska
Publikováno v:
Toxicology. 260:68-76
We have previously shown that short-term, high-dose exposure of mice to the environmentally persistent perfluorooctanoate (PFOA) results in thymic and splenic atrophy and the attenuation of specific humoral immune responses. Here we characterize the
Publikováno v:
Biochemical Journal. 412:123-130
NF1 (nuclear factor 1) binds to two upstream elements of the human ANT2 (adenine nucleotide translocator-2) promoter and actively represses expression of the gene in growth-arrested diploid skin fibroblasts [Luciakova, Barath, Poliakova, Persson and
Publikováno v:
European Journal of Biochemistry. 271:1781-1788
The human adenine nucleotide translocase-2 (ANT2) promoter contains a silencer region that confers partial repression on the heterologous herpes simplex virus thymidine kinase (HSVtk) promoter [Barath, P., Albert-Fournier, B., Luciakova, K., Nelson,
Publikováno v:
Biochemical Pharmacology. 66:749-756
We have previously demonstrated that severe adipose tissue atrophy occurs upon dietary treatment of mice with potent peroxisome proliferators (PPs). This atrophy occurs subsequent to peroxisome proliferation in the liver and may represent a novel add
Repression of the Human Adenine Nucleotide Translocase-2 Gene in Growth-arrested Human Diploid Cells
Publikováno v:
Journal of Biological Chemistry. 278:30624-30633
Adenine nucleotide translocase-2 (ANT2) catalyzes the exchange of ATP for ADP across the mitochondrial membrane, thus playing an important role in maintaining the cytosolic phosphorylation potential required for cell growth. Expression of ANT2 is act
Publikováno v:
Biochemical Pharmacology. 63:1893-1900
Peroxisome proliferators (PPs) are a large class of structurally diverse chemicals, which includes drugs designed to improve the metabolic abnormalities linking hypertriglyceridemia to diabetes, hyperglycemia, insulin-resistance and atherosclerosis.
Publikováno v:
European Journal of Biochemistry. 268:5497-5503
The human adenine nucleotide translocator-2 promoter is activated by adjacent Sp1 activation elements centered at nucleotides -79 and -68 (Abox and Bbox, respectively), and is repressed by Sp1 bound to a GC element (Cbox) that lies adjacent to transc