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pro vyhledávání: '"B. Darblade"'
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Autor:
Jean-Paul Hieble, Gérard Benoit, Stephanie Oger, B. Darblade, F. Giuliano, D. Gorny, Thierry Lebret, Laurent Alexandre, D. Behr-Roussel
Publikováno v:
Urology. 68:442-448
Objectives Increased urinary bladder detrusor smooth muscle phasic contractility has been suggested to be associated with idiopathic bladder overactivity (OAB). We examined the role of voltage-dependent l -type calcium channels, adenosine triphosphat
Autor:
Laurent Alexandre, B. Darblade, Alexandra Oudot, Jacques Bernabé, François Giuliano, Delphine Behr-Roussel, Sandrine Compagnie
Publikováno v:
The Journal of Sexual Medicine. 3:596-603
Introduction Erectile dysfunction (ED) and cardiovascular diseases share the same risk factors. Although the use of hypercholesterolemic rabbit models has proven to be useful to illustrate the link between ED and hypercholesterolemia, the cost of dai
Autor:
D. Gorny, B. Darblade, D. Brooks, J.-P. Hieble, F. Giuliano, Laurent Alexandre, G. Benoit, D. Behr-Roussel, Thierry Lebret
Publikováno v:
World Journal of Urology. 23:147-151
The aim of this study is to evaluate the potency of piboserod (SB 207266), a selective 5-HT(4) receptor antagonist, at inhibiting the 5-HT(4)-mediated potentiating effect of serotonin (5-HT) on the neurally-mediated contractile responses of human det
Autor:
Andrée Krust, Jean-François Arnal, Kenneth S. Korach, C. Pendaries, Philippe Rochaix, Francis Bayard, B. Darblade, Pierre Chambon
Publikováno v:
Proceedings of the National Academy of Sciences. 99:2205-2210
Two isoforms of estrogen receptor (ER) have been described: ERα and ERβ. The initial gene targeting of ERα, consisting in the introduction of a Neo cassette in exon 1 [αERKO, hereafter called ERα-Neo KO (knockout)], was reported in 1993. More re
Autor:
Andrée Krust, F. Bayard, C. Pendaries, B. Darblade, M.-J. Fouque, J. Rami, Pierre Chambon, S. Dupont, J. F. Arnal
Publikováno v:
Circulation research. 90(4)
Although estradiol (E 2 ) has been recognized to exert several vasculoprotective effects in several species, its effects in mouse vasomotion are unknown, and consequently, so is the estrogen receptor subtype mediating these effects. We investigated t
Publikováno v:
Journal of vascular research. 38(3)
Nitric oxide (NO) is produced by a family of three isoenzymes: the endothelial, inducible and neuronal NO synthases. L-Nitroarginine methyl ester (L-NAME) is the most commonly used inhibitor of NO synthase activity. The goal of the present study was
Publikováno v:
Journal de la Societe de biologie. 194(3-4)
Furchgott et al. demonstrated in 1980 that relaxation of arterial smooth muscle cells in response to acetylcholine is dependent on the integrity of endothelium. They named the factor responsible of this intercellular relationship EDRF (Endothelium De
Publikováno v:
Therapie. 54(3)
Two isoforms of oestrogen receptors (alpha and beta) have been identified in the cells of the arterial wall, and a heterogeneity of their expression according to the animal species, the vascular beds and the sex has been reported. Oestrogens can thus
Autor:
François Giuliano, Laurent Alexandre, B. Darblade, A. Oudot, Delphine Behr-Roussel, J. Bernabé, Sandrine Compagnie
Publikováno v:
European Urology Supplements. 5:104