Výsledky vyhledávání - "B. DE PASCUAL-TERESA"

Design and synthesis of novel dual-target agents for HDAC1 and CK2 inhibition

Autor: J. Hernández-Toribio, R. R. Panchuk, Ana Ramos, M. Purwin, B. de Pascual-Teresa, Kamila Filipiak, N. R. Skorokhyd, Claire Coderch

Publikováno v: RSC Advances. 6:66595-66608

Drug entities able to address multiple targets can be more effective than those directed to just one biological target. We disclose herein a series of novel dual inhibitors to target histone deacetylase 1 (HDAC 1) and protein kinase CK2. Our bifuncti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4189c8270bc040f8bca7a4973dea8bdb
https://doi.org/10.1039/c6ra09717k

Zobrazit plný text záznamu

Development of inhibitors of receptor protein tyrosine phosphatase beta/zeta (PTPRZ1) as candidates for CNS disorders

Autor: M. PASTOR, R. FERNANDEZ-CALLE, B. DI GERONIMO, M. VICENTE-RODRIGUEZ, J. ZAPICO, E. GRAMAGE, C. CODERCH, C. PEREZ-GARCIA, A. LASEK, L. PUCHADES-CARRASCO, A. PINEDA-LUCENA, B. DE PASCUAL-TERESA, G. HERRADON, A. RAMOS

Publikováno v: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

A new series of blood-brain barrier permeable molecules designed to mimic the activity of Pleiotrophin in the CNS has been designed and synthesized. These compounds exert their action by interacting with the intracellular domain PD1 of the Protein Ty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7b7c0a6de32e31736b36758dab896ec8
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=6997

Zobrazit plný text záznamu

Synthesis, biological activity and structural study of new benzotriazole-based protein kinase CK2 inhibitors

Autor: N. R. Skorokhyd, Maciej Masłyk, Alexander Schnitzler, R. R. Panchuk, B. de Pascual-Teresa, Ana Ramos, Claire Coderch, Robert Swider, Karsten Niefind, José María Zapico

Publikováno v: RSC Advances. 5:72482-72494

A new series of 4,5,6,7-tetrabromobenzotriazole (TBB) derivatives was synthesized and characterized as CK2 inhibitors. They were readily synthesized using a click chemistry approach based on a Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65fe95a75016e4fe755a76f66583e956
https://doi.org/10.1039/c5ra12114k

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

MMP-2 Selectivity in Hydroxamate-Type Inhibitors

Autor: José María Zapico, Pilar Serra, Ana Ramos, M. Bruczko, Mario A. García, B. de Pascual-Teresa, Anna Pućkowska, Sonsoles Martín-Santamaría

Publikováno v: Current Medicinal Chemistry. 19:1036-1064

Extracellular matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases involved in physiological and pathological processes, through the cleavage of extracellular matrix. MMPs are capable of degrading essentially all mat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db1c8cdd20c827b477b67cd247c5d08
https://doi.org/10.2174/092986712799320628

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání