Ontogeny of Hepatic Transporters and Drug-Metabolizing Enzymes in Humans and in Nonclinical Species

Autor: E. van Peer, Pieter Annaert, A. C. Kuik, Karel Allegaert, S. Van Cruchten, Johan Nicolaï, SN de Wildt, L. De Schaepdrijver, Stephan Schmidt, Justine Badée, B. D. van Groen, Anne Smits

Publikováno v: Pharmacological Reviews, 73, 2, pp. 597-678
Pharmacological Reviews, 73, 597-678
Pharmacological reviews
Pharmacological Reviews, 73(2), 597-678. American Society for Pharmacology and Experimental Therapeutics

The liver represents a major eliminating and detoxifying organ, determining exposure to endogenous compounds, drugs, and other xenobiotics. Drug transporters (DTs) and drug-metabolizing enzymes (DMEs) are key determinants of disposition, efficacy, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18af2039c39986614703e802e710dd77
https://pubmed.ncbi.nlm.nih.gov/33608409