Zobrazeno 1 - 10 of 13 pro vyhledávání: '"B. D. Potts"'
2
Synthesis and pharmacological evaluation of a major metabolite of ameltolide, a potent anticonvulsant
Autor: R.R. Lawson, David W. Robertson, B D Potts, J D Leander, Joseph H. Krushinski, Parli Cj, E. E. Beedle
Publikováno v: Journal of Medicinal Chemistry. 34:1253-1257
The 4-aminobenzamides have provided several anticonvulsants that have been extensively investigated. Ameltolide, 4-amino-N-(2,6-dimethylphenyl)benzamide (compound 2,LY201116), is the most potent analogue studied to date. This drug is inactivated in v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc2a3d5e71957e430b44839879c867f
https://doi.org/10.1021/jm00108a003
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3
Relation of plasma and brain concentrations of the anticonvulsant ameltolide to its pharmacologic effects
Autor: Lodge D, Parli Cj, B D Potts, Leander Jd
Publikováno v: Epilepsia. 33(4)
Summary: Ameltolide, a newly described anticonvulsant, was studied to determine the relation between dose administered, plasma and brain concentrations, and pharmacologic effects. The relation of the N-acetyl metabolite and the OH-N-acetyl metabolite
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4a71a26002831a72a2c61c3859a4a1
https://pubmed.ncbi.nlm.nih.gov/1628587
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4
Evaluation of LY203647 on cardiovascular leukotriene D4 receptors and myocardial reperfusion injury
Autor: R A, Hahn, B R, MacDonald, E, Morgan, B D, Potts, C J, Parli, L E, Rinkema, C A, Whitesitt, W S, Marshall
Publikováno v: The Journal of pharmacology and experimental therapeutics. 260(3)
In vitro studies have shown LY203647 to be a selective antagonist of contractile responses to leukotriene (LT) D4 and LTE4 in guinea pig ileum, trachea and lung parenchyma. In pithed rat, i.v. injection of LTD4 produced pressor responses that were se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::45cffe9c0184d6ecc8bbb6f352affe2a
https://pubmed.ncbi.nlm.nih.gov/1312172
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5
Antagonism of leukotriene B4 receptors does not limit canine myocardial infarct size
Autor: R A, Hahn, B R, MacDonald, P J, Simpson, B D, Potts, C J, Parli
Publikováno v: The Journal of pharmacology and experimental therapeutics. 253(1)
Injection of leukotriene (LT)B4 (0.1-3 micrograms/kg i.v.) in normal anesthetized dogs produced dose-related leukopenia that was accompanied by arterial hypotension and tachycardia at higher tested doses. LTD4 (0.1-3 micrograms/kg i.v.), in contrast,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a156e82716785ac35b340b2e6ff6e492
https://pubmed.ncbi.nlm.nih.gov/2158553
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7
Gas-chromatographic quantification of methylphenidate in plasma with use of solid-phase extraction and nitrogen-sensitive detection
Autor: Catherine A. Martin, Mary Vore, B D Potts
Publikováno v: Clinical Chemistry. 30:1374-1377
The gas-chromatographic assay for methylphenidate described here involves isolation by solid-phase extraction and quantification by thermionic nitrogen-phosphorus detection. Methylphenidate and the internal standard, ethylphenidate, are extracted fro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f17f47bbd8246805f793a12f5931024e
https://doi.org/10.1093/clinchem/30.8.1374
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8
Metabolism of the prodrug DEGA (N-(2,6-dimethylphenyl)-4-[[(diethylamino)acetyl]amino]benzamide) to the potent anticonvulsant LY201116 in mice. Effect of bis-(p-nitrophenyl)phosphate
Autor: C J, Parli, E, Evenson, B D, Potts, E, Beedle, R, Lawson, D W, Robertson, J D, Leander
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 16(5)
In mice, the diethylglycineamide analogue of LY201116, DEGA (N-(2,6-dimethylphenyl)-4-[[(diethylamino)acetyl]amino]benzamide), is metabolized by consecutive N-deethylations for form MEGA and GA; the monoethylglycineamide and glycineamide analogues of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f9594fa026be61a57f456dad0ff97ab
https://pubmed.ncbi.nlm.nih.gov/2906594
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9
Pharmacokinetics, metabolism, and disposition of 6-chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine (SKF 86466) in rats and dogs
Autor: C T, Gombar, K, Straub, P, Levandoski, L, Gutzait, J, Swagzdis, C, Garvie, G, Joseph, B D, Potts, B A, Mico
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 14(5)
The pharmacokinetics and metabolism of 6-chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine (SKF 86466) have been studied in rats and dogs. Using radiolabeled SKF 86466, it was shown that the compound was completely absorbed from the gastrointestina
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::05c87a9c4910e890cfe93927c9dfb428
https://pubmed.ncbi.nlm.nih.gov/2876859
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10
Discovery and anticonvulsant activity of the potent metabolic inhibitor 4-amino-N-(2,6-dimethylphenyl)-3,5-dimethylbenzamide
Autor: David W. Robertson, Parli Cj, Clark Cr, E. E. Beedle, R.R. Lawson, J D Leander, B D Potts
Publikováno v: Journal of medicinal chemistry. 30(10)
Compound 2 [4-amino-N-(2,6-dimethylphenyl)benzamide] is an effective anticonvulsant in several animal models. For example, following oral administration to mice, it antagonized maximal electroshock (MES) induced seizures with an ED50 of 1.7 mg/kg. Du
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975e9d109909e4faafc3d9864a1aeae6
https://pubmed.ncbi.nlm.nih.gov/3656350
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