Zobrazeno 1 - 10
of 118
pro vyhledávání: '"B. Czepulkowski"'
Autor:
Patrick J. Duriez, B. Czepulkowski, Alison H. Banham, Linden Lyne, James W. Wells, Joseph Collin, Barbara-Ann Guinn, Ghulam J. Mufti
Publikováno v:
Genes, Chromosomes and Cancer. 54:288-302
To increase our knowledge of leukaemia‐associated antigens, especially in acute myeloid leukaemia (AML) M4, we prepared a phage display cDNA library using mRNA from the bone marrow cells of a patient with AML M4 at diagnosis. We immunoscreened 106
Autor:
Joop Gaken, Jie Jiang, Alexander E. Smith, Ghulam J. Mufti, Robin M. Ireland, Steven Best, Azim M Mohamedali, Syed A Mian, Austin G. Kulasekararaj, B. Czepulkowski
Publikováno v:
The Lancet. Haematology. 2(5)
Summary Background A mechanism for clonal growth advantage in isolated del(5q) disease remains elusive. CSNK1A1 resides on the critically deleted region, and deletion of this gene has been shown in mouse knockout and transplantation studies to produc
Autor:
Hideo Yagita, Barbara-Ann Guinn, Lucas Chan, Stuart A. Berger, Ghulam J. Mufti, Ko Okumura, Farzin Farzaneh, B. Czepulkowski, Adam T. C. Cheuk
Publikováno v:
Cancer Immunology, Immunotherapy. 55:68-75
We describe the modification of tumour cells to enhance their capacity to act as antigen presenting cells with particular focus on the use of costimulatory molecules to do so. We have been involved in the genetic modification of tumour cells to prepa
Autor:
K. Saunders, Mallika Sekhar, Ghulam J. Mufti, J.P.L.A. Hayes, Aloysius Ho, B. Czepulkowski, R. Sivalingam, M. Cummins, M. Aldouri
Publikováno v:
Cancer Genetics and Cytogenetics. 156:154-157
Interstitial deletion of the long arm of chromosome 20, as the sole abnormality, is commonly observed in myeloid malignancies, including myeloproliferative disorder, myelodysplastic syndrome, and acute myeloid leukemia. The breakpoints of the deletio
Publikováno v:
Cancer Genetics and Cytogenetics. 145:78-81
We present a short report here of two more patients with trisomy 2 as the sole chromosomal abnormality in a hematologic malignancy. Although trisomy 2 is a recognized abnormality in neoplasms, particularly hepatoblastomas, to the best of our knowledg
Autor:
B. Czepulkowski, Debra M. Lillington, Robin Russell-Jones, Sean Whittaker, Xin Mao, Bryan D. Young
Publikováno v:
Genes, Chromosomes and Cancer. 36:250-260
Sezary syndrome (SS) is a rare form of erythrodermic cutaneous T-cell lymphoma with hematological involvement and a poor prognosis. At present little is known about the molecular pathogenesis of this malignancy. To address this issue, we analyzed 28
Autor:
Judith C. W. Marsh, Austin G. Kulasekararaj, B. Czepulkowski, Alexander E. Smith, Azim M Mohamedali, Syed A Mian, Joop Gaken, Ghulam J. Mufti, Shreyans Gandhi, Jie Jiang
Publikováno v:
Blood. 124(17)
The distinction between acquired aplastic anemia (AA) and hypocellular myelodysplastic syndrome (hMDS) is often difficult, especially nonsevere AA. We postulated that somatic mutations are present in a subset of AA, and predict malignant transformati
Publikováno v:
Proceedings of the National Academy of Sciences. 98:1799-1804
Ever since monoclonal antibodies were produced in 1975 with mouse myeloma cells there has been interest in developing human myeloma cultures for the production of monoclonal antibodies. However, despite multiple attempts, no human myeloma line suitab
Autor:
Aleksandar Mijovic, Ghulam J. Mufti, K Fishlock, J.E. Parker, B. Czepulkowski, Antonio Pagliuca
Publikováno v:
British Journal of Haematology. 103:1075-1082
We performed flow cytometric analysis of CD34+ cell apoptosis in 59 patients with myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML) secondary to MDS (MDS-AML) using annexin V-FITC, which binds to exposed phosphatidylserine on apoptotic
Publikováno v:
Leukemia Research. 20:235-241
The genes for acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE) are located within regions subject to non-random chromosomal abnormalities in the myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML). Acetylcholinesterase is ma