Zobrazeno 1 - 10
of 931
pro vyhledávání: '"B. Corcoran"'
Publikováno v:
EJNMMI Physics, Vol 6, Iss 1, Pp 1-12 (2019)
Abstract Background 177Lu-DOTATATE peptide receptor radionuclide therapy is administered to patients on an inpatient and outpatient basis for the treatment of well-differentiated, metastatic neuroendocrine tumours. Following administration, these pat
Externí odkaz:
https://doaj.org/article/780ede7c904d4ca698d55eae37d897f7
Publikováno v:
Health Science Reports, Vol 6, Iss 6, Pp n/a-n/a (2023)
Abstract Background and Aims Adequate postoperative analgesia and prevention of post‐op nausea and vomiting (PONV) are core components of modern day anaesthesia and peri‐operative care. As well as contributing to overall morbidity, postoperative
Externí odkaz:
https://doaj.org/article/046946f2c18147a69df57fb466ef97b0
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Bacterial vaginosis (BV) is a recurrent dysbiosis that is frequently associated with preterm birth, increased risk for acquisition of human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs). The overgrowth of a ke
Externí odkaz:
https://doaj.org/article/96b909bd22174af2b821e4796f87297f
Autor:
Pégah Jalili, Danae Bowen, Adam Langenbucher, Shinho Park, Kevin Aguirre, Ryan B. Corcoran, Angela G. Fleischman, Michael S. Lawrence, Lee Zou, Rémi Buisson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The DNA cytosine deaminases APOBEC3A and APOBEC3B have emerged from cancer genomics studies as drivers of mutation in cancers and tumor heterogeneity. Here the authors present a computational approach to identify the RNA mutations specifically driven
Externí odkaz:
https://doaj.org/article/ce56509c93e8439dabb97f9c99412c8c
Autor:
Jun Tian, Jonathan H. Chen, Sherry X. Chao, Karin Pelka, Marios Giannakis, Julian Hess, Kelly Burke, Vjola Jorgji, Princy Sindurakar, Jonathan Braverman, Arnav Mehta, Tomonori Oka, Mei Huang, David Lieb, Maxwell Spurrell, Jill N. Allen, Thomas A. Abrams, Jeffrey W. Clark, Andrea C. Enzinger, Peter C. Enzinger, Samuel J. Klempner, Nadine J. McCleary, Jeffrey A. Meyerhardt, David P. Ryan, Matthew B. Yurgelun, Katie Kanter, Emily E. Van Seventer, Islam Baiev, Gary Chi, Joy Jarnagin, William B. Bradford, Edmond Wong, Alexa G. Michel, Isobel J. Fetter, Giulia Siravegna, Angelo J. Gemma, Arlene Sharpe, Shadmehr Demehri, Rebecca Leary, Catarina D. Campbell, Omer Yilmaz, Gad A. Getz, Aparna R. Parikh, Nir Hacohen, Ryan B. Corcoran
Publikováno v:
Nature Medicine. 29:458-466
While BRAF inhibitor combinations with EGFR and/or MEK inhibitors have improved clinical efficacy in BRAFV600E colorectal cancer (CRC), response rates remain low and lack durability. Preclinical data suggest that BRAF/MAPK pathway inhibition may augm
Autor:
Yi Sun, Or-yam Revach, Seth Anderson, Emily A. Kessler, Clara H. Wolfe, Anne Jenney, Caitlin E. Mills, Emily J. Robitschek, Thomas G. R. Davis, Sarah Kim, Amina Fu, Xiang Ma, Jia Gwee, Payal Tiwari, Peter P. Du, Princy Sindurakar, Jun Tian, Arnav Mehta, Alexis M. Schneider, Keren Yizhak, Moshe Sade-Feldman, Thomas LaSalle, Tatyana Sharova, Hongyan Xie, Shuming Liu, William A. Michaud, Rodrigo Saad-Beretta, Kathleen B. Yates, Arvin Iracheta-Vellve, Johan K. E. Spetz, Xingping Qin, Kristopher A. Sarosiek, Gao Zhang, Jong Wook Kim, Mack Y. Su, Angelina M. Cicerchia, Martin Q. Rasmussen, Samuel J. Klempner, Dejan Juric, Sara I. Pai, David M. Miller, Anita Giobbie-Hurder, Jonathan H. Chen, Karin Pelka, Dennie T. Frederick, Susanna Stinson, Elena Ivanova, Amir R. Aref, Cloud P. Paweletz, David A. Barbie, Debattama R. Sen, David E. Fisher, Ryan B. Corcoran, Nir Hacohen, Peter K. Sorger, Keith T. Flaherty, Genevieve M. Boland, Robert T. Manguso, Russell W. Jenkins
Publikováno v:
Nature. 615:158-167
Autor:
Thomas Lewis, David B. Corcoran, David E. Thurston, Peter J. Giles, Kevin Ashelford, Elisabeth J. Walsby, Christopher D. Fegan, Andrea G.S. Pepper, Khondaker Miraz Rahman, Chris Pepper
Publikováno v:
Haematologica, Vol 106, Iss 4 (2020)
Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are incurable hematological malignancies that are pathologically linked with aberrant NF-κB activation. In this study, we identified a group of novel C8-linked benzofused Pyrrolo[2,1-c][1,
Externí odkaz:
https://doaj.org/article/0911458f4f234882b035a6312aa7bbe9
Autor:
Sophia C. Kamran, Jeffrey W. Clark, Hui Zheng, Darrell R. Borger, Lawrence S. Blaszkowsky, Jill N. Allen, Eunice L. Kwak, Jennifer Y. Wo, Aparna R. Parikh, Ryan D. Nipp, Janet E. Murphy, Lipika Goyal, Andrew X. Zhu, A. John Iafrate, Ryan B. Corcoran, David P. Ryan, Theodore S. Hong
Publikováno v:
Cancer Medicine, Vol 7, Iss 7, Pp 2934-2942 (2018)
Abstract Recent reports demonstrate inferior outcomes associated with primary right‐sided vs left‐sided colorectal tumors in patients with metastatic colorectal cancer (mCRC). We sought to describe our experience with mCRC patients on whom we hav
Externí odkaz:
https://doaj.org/article/d8d818ceb29849aab15f3fbceae5ca4e
Autor:
Moshe Sade-Feldman, Yunxin J. Jiao, Jonathan H. Chen, Michael S. Rooney, Michal Barzily-Rokni, Jean-Pierre Eliane, Stacey L. Bjorgaard, Marc R. Hammond, Hans Vitzthum, Shauna M. Blackmon, Dennie T. Frederick, Mehlika Hazar-Rethinam, Brandon A. Nadres, Emily E. Van Seventer, Sachet A. Shukla, Keren Yizhak, John P. Ray, Daniel Rosebrock, Dimitri Livitz, Viktor Adalsteinsson, Gad Getz, Lyn M. Duncan, Bo Li, Ryan B. Corcoran, Donald P. Lawrence, Anat Stemmer-Rachamimov, Genevieve M. Boland, Dan A. Landau, Keith T. Flaherty, Ryan J. Sullivan, Nir Hacohen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Resistance to immune-checkpoint blockade often occurs in treated patients. Here, the authors demonstrate that B2M loss is a mechanism of primary and acquired resistance to therapies targeting CTLA4 or PD-1 in melanoma patients.
Externí odkaz:
https://doaj.org/article/4b7fd694a84645dbafce545e168de8d2
Autor:
Paul S, Myles, Toby, Richards, Andrew, Klein, Erica M, Wood, Sophie, Wallace, Mark A, Shulman, Catherine, Martin, Rinaldo, Bellomo, Tomás B, Corcoran, Philip J, Peyton, David A, Story, Kate, Leslie, Andrew, Forbes
Publikováno v:
British Journal of Anaesthesia. 129:346-354
Compared with anaemia before surgery, the underlying pathogenesis and implications of postoperative anaemia are largely unknown.This retrospective cohort study analysed prospective data obtained from 2983 adult patients across 47 centres enrolled in