Microenvironmental IL1 1 β promotes metastatic colonisation of breast cancer cells in the bone via activation of Wnt-dependent cancer stem cell activity

Autor: Eyre, Rachel, Alférez, Denis G, Santiago-Gómez, Angélica, Spence, Kath, McConnell, James C, Hart, Claire, Simões, Bruno M, Tulotta, Claudia, Storer, Joanna, Gurney, Austin, Clarke, Noel, Brown, Michael D, Howell, Sacha J, Sims, Andrew, Farnie, Gillian, Ottewell, Penelope D, B. Clarke, Robert

Publikováno v: Eyre, R, Alférez, D G, Santiago-Gómez, A, Spence, K, McConnell, J C, Hart, C, Simões, B M, Tulotta, C, Storer, J, Gurney, A, Clarke, N, Brown, M D, Howell, S J, Sims, A, Farnie, G, Ottewell, P D & B. Clarke, R 2019, ' Microenvironmental IL1 1 β promotes metastatic colonisation of breast cancer cells in the bone via activation of Wnt-dependent cancer stem cell activity ', Nature Communications . https://doi.org/10.1038/s41467-019-12807-0

Dissemination of tumour cells to the bone marrow is an early event in breast cancer, however cells may lie dormant for many years before clinical bone metastases develop. Treatment for bone metastases is not curative, therefore new adjuvant therapies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::24e54064ffc0b4b52259e7470f5d54b7
https://hdl.handle.net/20.500.11820/39f1561c-38c8-4a4f-9564-b7fa13466ddd