Zobrazeno 1 - 10
of 1 315
pro vyhledávání: '"B. Caldwell"'
Autor:
Ammar A. Abdelrahman, Porsche V. Sandow, Jing Wang, Zhimin Xu, Modesto Rojas, John S. Bomalaski, Tahira Lemtalsi, Ruth B. Caldwell, Robert W. Caldwell
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102020- (2024)
Objective: Chronic inflammation and oxidative stress mediate the pathological progression of diabetic complications, like diabetic retinopathy (DR), peripheral neuropathy (DPN) and impaired wound healing. Studies have shown that treatment with a stab
Externí odkaz:
https://doaj.org/article/c237de2e14d94104aab7e234e7dfe042
Autor:
Phoebe Valdes, Kenneth W. Henry, Michael Q. Fitzgerald, Koushik Muralidharan, Andrew B. Caldwell, Srinivasan Ramachandran, Lawrence S. B. Goldstein, William C. Mobley, Douglas R. Galasko, Shankar Subramaniam
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-8 (2023)
Abstract Non-familial Alzheimer’s disease (AD) occurring before 65 years of age is commonly referred to as early-onset Alzheimer’s disease (EOAD) and constitutes ~ 5–6% of all AD cases (Mendez et al. in Continuum 25:34–51, 2019). While EOAD e
Externí odkaz:
https://doaj.org/article/3ea7c071f924471b9c2a68f75dab7070
Autor:
Syed A. H. Zaidi, Zhimin Xu, Tahira Lemtalsi, Porsche Sandow, Sruthi Athota, Fang Liu, Stephen Haigh, Yuqing Huo, S. Priya Narayanan, David J. R. Fulton, Modesto A. Rojas, Abdelrahman Y. Fouda, Robert W. Caldwell, Ruth B. Caldwell
Publikováno v:
Cell Death and Disease, Vol 14, Iss 10, Pp 1-13 (2023)
Abstract We previously found that global deletion of the mitochondrial enzyme arginase 2 (A2) limits optic nerve crush (ONC)-induced neuronal death. Herein, we examined the cell-specific role of A2 in this pathology by studies using wild type (WT), n
Externí odkaz:
https://doaj.org/article/1a43c41d16474a4bb0b5407c1612d0be
Autor:
Esraa Shosha, Rami A. Shahror, Carol A. Morris, Zhimin Xu, Rudolf Lucas, Meghan E. McGee-Lawrence, Nancy J. Rusch, Ruth B. Caldwell, Abdelrahman Y. Fouda
Publikováno v:
Cell Death and Disease, Vol 14, Iss 9, Pp 1-14 (2023)
Abstract The enzyme arginase 1 (A1) hydrolyzes the amino acid arginine to form L-ornithine and urea. Ornithine is further converted to polyamines by the ornithine decarboxylase (ODC) enzyme. We previously reported that deletion of myeloid A1 in mice
Externí odkaz:
https://doaj.org/article/86d72afde3964ebdb05e33acaea7cc03
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Opioid use disorder (OUD) among pregnant women has become an epidemic in the United States. Pharmacological interventions for maternal OUD most commonly involve methadone, a synthetic opioid analgesic that attenuates withdrawal symptoms and
Externí odkaz:
https://doaj.org/article/5b242ce097b543eb8110e29d9d20b666
Autor:
Syed A. H. Zaidi, Tahira Lemtalsi, Zhimin Xu, Isabella Santana, Porsche Sandow, Leila Labazi, Robert W. Caldwell, Ruth B. Caldwell, Modesto A. Rojas
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-18 (2023)
Abstract Background We have investigated the efficacy of a new strategy to limit pathological retinal neovascularization (RNV) during ischemic retinopathy by targeting the cholesterol metabolizing enzyme acyl-coenzyme A: cholesterol transferase 1 (AC
Externí odkaz:
https://doaj.org/article/244c1151a5824f26b7731f1f299bdc78
Autor:
Andrew B. Caldwell, Balaji G. Anantharaman, Srinivasan Ramachandran, Phuong Nguyen, Qing Liu, Ivy Trinh, Douglas R. Galasko, Paula A. Desplats, Steven L. Wagner, Shankar Subramaniam
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-7 (2022)
Abstract Alzheimer’s disease (AD) manifested before age 65 is commonly referred to as early-onset AD (EOAD) (Reitz et al. Neurol Genet. 2020;6:e512). While the majority (> 90%) of EOAD cases are not caused by autosomal-dominant mutations in PSEN1,
Externí odkaz:
https://doaj.org/article/69bf4d2236e24c6b976bca1f7cb26c81
Autor:
Abdelrahman Y. Fouda, Zhimin Xu, Jutamas Suwanpradid, Modesto Rojas, Esraa Shosha, Tahira Lemtalsi, Chintan Patel, Ji Xing, Syed A. Zaidi, Wenbo Zhi, Brain K. Stansfield, Paul Ning-Man Cheng, S. Priya Narayanan, R. William Caldwell, Ruth B. Caldwell
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-12 (2022)
Abstract Current therapies for treatment of proliferative retinopathy focus on retinal neovascularization (RNV) during advanced disease and can trigger adverse side-effects. Here, we have tested a new strategy for limiting neurovascular injury and pr
Externí odkaz:
https://doaj.org/article/9425c35153c5408eae0768802d3f931a
Autor:
Shengshuai Shan, Fang Liu, Edith Ford, Ruth B. Caldwell, S. Priya Narayanan, Payaningal R. Somanath
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 162, Iss , Pp 114714- (2023)
Proliferative retinopathies are the leading cause of irreversible blindness in all ages, and there is a critical need to identify novel therapies. We investigated the impact of triciribine (TCBN), a tricyclic nucleoside analog and a weak Akt inhibito
Externí odkaz:
https://doaj.org/article/4c5450ac96e4416eabf40d00605e6b7f
Autor:
Madhuri Rudraraju, Shengshuai Shan, Fang Liu, Jennifer Tyler, Ruth B. Caldwell, Payaningal R. Somanath, S. Priya Narayanan
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 22, p 7145 (2023)
Compromised blood-retinal barrier (BRB) integrity is a significant factor in ocular diseases like uveitis and retinopathies, leading to pathological vascular permeability and retinal edema. Adherens and tight junction (AJ and TJ) dysregulation due to
Externí odkaz:
https://doaj.org/article/6595df86c1544beab2334a57225fe148