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Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer's disease microglia.

Autor: Huang AY; Division of Genetics and Genomics and Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhou Z; Division of Genetics and Genomics and Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Talukdar M; Division of Genetics and Genomics and Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard-MIT MD/PhD Program, Boston, MA, USA., Miller MB; Division of Genetics and Genomics and Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Neuropathology, Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Chhouk B; Division of Genetics and Genomics and Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA., Enyenihi L; Division of Genetics and Genomics and Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard-MIT MD/PhD Program, Boston, MA, USA., Rosen I; Division of Genetics and Genomics and Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA., Stronge E; Division of Genetics and Genomics and Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard-MIT MD/PhD Program, Boston, MA, USA., Zhao B; Division of Genetics and Genomics and Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kim D; Division of Genetics and Genomics and Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Department of Otorhinolaryngology, Severance Hospital, Yonsei University Health System, Yonsei University College of Medicine, Seoul, South Korea., Choi J; Division of Genetics and Genomics and Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Khoshkhoo S; Division of Genetics and Genomics and Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Kim J; Division of Genetics and Genomics and Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biological Sciences, Sungkyunkwan University, Suwon, South Korea., Ganz J; Division of Genetics and Genomics and Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Travaglini K; Allen Institute for Brain Science, Seattle, WA, USA., Gabitto M; Allen Institute for Brain Science, Seattle, WA, USA., Hodge R; Allen Institute for Brain Science, Seattle, WA, USA., Kaplan E; Allen Institute for Brain Science, Seattle, WA, USA., Lein E; Allen Institute for Brain Science, Seattle, WA, USA., De Jager PL; Center for Translational and Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical College, Chicago, IL, USA., Lee EA; Division of Genetics and Genomics and Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Walsh CA; Division of Genetics and Genomics and Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Boston, MA USA.; Departments of Neurology, Harvard Medical School, Boston, MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 04. Date of Electronic Publication: 2024 Jan 04.

Cell lineage analysis with somatic mutations reveals late divergence of neuronal cell types and cortical areas in human cerebral cortex.

Autor: Kim SN; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, 02115, MA, USA.; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, 02115, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, 02115, MA, USA., Viswanadham VV; Department of Biomedical Informatics, Harvard Medical School, Boston, 02115, MA, USA.; Bioinformatics and Integrative Genomics Program, Harvard Medical School, Boston, 02115, MA, USA., Doan RN; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, 02115, MA, USA., Dou Y; Department of Biomedical Informatics, Harvard Medical School, Boston, 02115, MA, USA., Bizzotto S; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, 02115, MA, USA.; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, 02115, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA., Khoshkhoo S; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, 02115, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Boston, 02115, MA, USA., Huang AY; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, 02115, MA, USA.; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, 02115, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA., Yeh R; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, 02115, MA, USA., Chhouk B; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, 02115, MA, USA., Truong A; Research Computing, Harvard Medical School, Boston, 02115, MA, USA., Chappell KM; Research Computing, Harvard Medical School, Boston, 02115, MA, USA., Beaudin M; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, 02115, MA, USA.; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, 02115, MA, USA., Barton A; Department of Biomedical Informatics, Harvard Medical School, Boston, 02115, MA, USA.; Bioinformatics and Integrative Genomics Program, Harvard Medical School, Boston, 02115, MA, USA., Akula SK; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, 02115, MA, USA.; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, 02115, MA, USA., Rento L; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, 02115, MA, USA., Lodato M; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, 02115, MA, USA.; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, 02115, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA., Ganz J; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, 02115, MA, USA.; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, 02115, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA., Szeto RA; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, 02115, MA, USA., Li P; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, 02115, MA, USA.; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, 02115, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA., Tsai JW; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, 02115, MA, USA.; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, 02115, MA, USA., Hill RS; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, 02115, MA, USA.; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, 02115, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA., Park PJ; Department of Biomedical Informatics, Harvard Medical School, Boston, 02115, MA, USA., Walsh CA; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, 02115, MA, USA.; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, 02115, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, 02115, MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 06. Date of Electronic Publication: 2023 Nov 06.