Výsledky vyhledávání - "B. C. Wilkes"

Subtleties of Structure-Agonist Versus Antagonist Relationships of Opioid Peptides and Peptidomimetics

Autor: G. Weltrowska, Peter W. Schiller, N. N. Chung, T. M.-D. Nguyen, B. C. Wilkes, Katharine A. Carpenter, Carole Lemieux, Irena Berezowska, Ralf Schmidt

Publikováno v: Journal of Receptors and Signal Transduction. 19:573-588

The development of novel delta opioid antagonists and delta opioid agonists structurally derived from the prototype delta antagonist TIPP (H-Tyr-Tic-Phe-Phe-OH), is reviewed. Both delta antagonists and delta agonists with extraordinary potency and un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ff6ec08fe100b439ef6a66137559d1
https://doi.org/10.3109/10799899909036673

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Opioid peptide analogs with novel activity profiles as potential therapeutic agents for use in analgesia

Autor: Peter W. Schiller, G. Weltrowska, Katharine A. Carpenter, T.M.-D. Nguyen, B. C. Wilkes, Y. Chen, Ralf Schmidt, N. N. Chung, Irena Berezowska, Carole Lemieux

Publikováno v: Peptide Science — Present and Future ISBN: 0792352718

Centrally acting μ opioid receptor agonists are potent analgesics but also produce a number of side effects, including dependence, tolerance, respiratory depression, adverse gastrointestinal effects, etc. The results of recent research indicate that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6aff7fe831e33bbf4d44fdae2d136e6
https://doi.org/10.1007/0-306-46864-6_225

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The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists

Autor: P W, Schiller, G, Weltrowska, I, Berezowska, T M, Nguyen, B C, Wilkes, C, Lemieux, N N, Chung

Publikováno v: Biopolymers. 51(6)

The discovery of the prototype delta opioid antagonists TIPP (H-Tyr-Tic-Phe-Phe-OH) and TIP (H-Tyr-Tic-Phe-OH) in 1992 was followed by extensive structure-activity relationship studies, leading to the development of analogues that are of interest as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89ea351811fa675cea252a2ba145a1b7
https://pubmed.ncbi.nlm.nih.gov/10797230

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Hydrophobic forces are responsible for the folding of a highly potent natriuretic peptide analogue at a membrane mimetic surface: an NMR study

Autor: K A, Carpenter, B C, Wilkes, A, De Léan, A, Fournier, P W, Schiller

Publikováno v: Biopolymers. 42(1)

A conformational study by nmr spectroscopy was performed with the highly active 28 residue hybrid natriuretic peptide analogue pBNP1 [M. Mimeault, A. De Léan, M. Lafleur, D. Bonenfant, and A. Fournier (1995) Biochemistry, Vol. 34, pp. 955-964], whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a55c7a288138940b7a4684671f87f4a
https://pubmed.ncbi.nlm.nih.gov/9209157

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Effect of aromatic amino acid substitutions in the 3-position of cyclic beta-casomorphin analogues on mu-opioid agonist/delta-opioid antagonist properties

Autor: R, Schmidt, B C, Wilkes, N N, Chung, C, Lemieux, P W, Schiller

Publikováno v: International journal of peptide and protein research. 48(5)

The beta-casomorphin-5 analog H-Tyr-c[-D-Orn-2-Nal-D-Pro-Gly-] (2-Nal = 2-naphthylalanine) was the first reported cyclic opioid peptide with mixed mu agonist/delta antagonist properties [R. Schmidt et al. (1994) J. Med. Chem. 37, 1136-1144]. The 2-Na

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b4e054c11e962714dbb0d28eed175d81
https://pubmed.ncbi.nlm.nih.gov/8956074

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