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In vivo Analysis Reveals that ATP-hydrolysis Couples Remodeling to SWI/SNF Release from Chromatin

Autor: Yuri M. Moshkin, Jan A. van der Knaap, Jeroen Demmers, Gillian E. Chalkley, B. C. Tilly, C. Peter Verrijzer, Tsung Wai Kan, Dick H. W. Dekkers

Publikováno v: eLife, Vol 10 (2021)
eLife, 10:e69424. eLife Sciences Publications
eLife

ATP-dependent chromatin remodelers control the accessibility of genomic DNA through nucleosome mobilization. However, the dynamics of genome exploration by remodelers, and the role of ATP hydrolysis in this process remain unclear. We used live-cell i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0321568f648c5e8d6e51cef262d04e5e
https://doi.org/10.1101/2021.04.23.441173

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Cholesterol Depletion and Genistein as Tools to Promote F508delCFTR Retention at the Plasma Membrane

Autor: B. C. Tilly, Adriaan B. Houtsmuller, Hugo R. de Jonge, Marcel J. C. Bijvelds, Christina H Lim, Kees Schoonderwoerd, Alex L. Nigg

Publikováno v: Cellular Physiology & Biochemistry, 20(5), 473-482. Cell Physiol Biochem Press (Germany)

F508delCFTR-, but not wtCFTR-, expressing fibroblasts resemble Niemann Pick type C cells in the massive intracellular accumulation of free cholesterol. The recruitment and activation of F508delCFTR by cholesterol depletion was studied.Filipin stainin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f144c268c6d83d7b851ff0bf4806be20
https://doi.org/10.1159/000107531

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Cyclic stretch and endothelin-1 mediated activation of chloride channels in cultured neonatal rat ventricular myocytes

Autor: B. C. Tilly, Jos M. J. Lamers, Henriette W. de Jonge, Dick H. W. Dekkers

Publikováno v: Clinical Science. 103:148S-151S

To date various types of Cl(-) currents have been recorded in cardiac myocytes from different regions of the heart and from different species. Most of these are silent under basal conditions, but are rapidly activated under the influence of various a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a83f8cce3f632784c3a0b4e48c6f6a
https://doi.org/10.1042/cs103s148s

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Signalling Mechanisms Involved in Volume Regulation of Intestinal Epithelial Cells

Autor: Hugo R. de Jonge, B. C. Tilly, Thea van der Wijk, Sebastian F.B. Tomassen

Publikováno v: Cellular Physiology & Biochemistry, 10, 289-296. Cell Physiol Biochem Press (Germany)

Most mammalian cells have developed compensatory mechanisms to respond to the variable osmotic stress caused by changes in the concentrations of intracellular osmo-active substances (e.g. glucose, amino acids, lactate) or by variations in the osmolar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d707f36e8bca83264196323ffe8bbfe6
https://doi.org/10.1159/000016359

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Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl − channel activation

Autor: Arie B. Vaandrager, Suzanne M. Lohmann, Ehrich M. E. Ehlert, Wendy E. M. Boomaars, B. C. Tilly, Adriaan B. Houtsmuller, Albert Smolenski, Marcel Edixhoven, Hugo R. de Jonge, Alice G. M. Bot

Publikováno v: Proceedings of the National Academy of Sciences. 95:1466-1471

A recently cloned isoform of cGMP-dependent protein kinase (cGK), designated type II, was implicated as the mediator of cGMP-provoked intestinal Cl − secretion based on its localization in the apical membrane of enterocytes and on its capacity to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7316b746c029be37b79055d57d00e0d
https://doi.org/10.1073/pnas.95.4.1466

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Ca(2+)-mobilizing hormones potentiate hypotonicity-induced activation of ionic conductances in Intestine 407 cells

Autor: Alice G. M. Bot, B. C. Tilly, N. Van Den Berghe, H. R. De Jonge, Marcel Edixhoven

Publikováno v: American Journal of Physiology-Cell Physiology. 267:C1271-C1278

Human Intestine 407 cells respond to hyposmotic stimulation by activating the conductive efflux of both Cl- and K+ (regulatory volume decrease) through pathways involving protein tyrosine phosphorylation (Tilly, B. C., N. van den Berghe, L. G. J. Ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5e0291af0485ca27056857ff9eacc5
https://doi.org/10.1152/ajpcell.1994.267.5.c1271

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Clustered CD3/TCR complexes do not transduce activation signals after bispecific monoclonal antibody-triggered lysis by cytotoxic T lymphocytes via CD3

Autor: C J Blank-Voorthuis, E Braakman, C P Ronteltap, B C Tilly, E Sturm, S O Warnaar, R L Bolhuis

Publikováno v: The Journal of Immunology. 151:2904-2914

Bispecfic mAb (bsmAb) directed against the CD3/TCR complex and a tumor-associated Ag (TAA) induces CTL-mediated lysis of TAA+ target cells. We have investigated whether bsmAb-pretargeted CTL can enter multiple lytic cycles. BsmAb-pretargeted CTL reta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da4a7fc6feb40f79562c22fd8527fd1e
https://doi.org/10.4049/jimmunol.151.6.2904

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Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances

Autor: H. R. De Jonge, Marcel Edixhoven, L. G. J. Tertoolen, B. C. Tilly, N. Van Den Berghe

Publikováno v: Journal of Biological Chemistry. 268:19919-19922

Using the human Intestine 407 cell line as a model, we investigated a possible role for tyrosine kinase(s) in regulating the ion efflux pathways induced by hyposmotic stimulation (regulatory volume decrease, RVD). Pretreatment of 125I(-)-and 86Rb(+)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1717f69ad0d7157d1fd12f4dbe089b58
https://doi.org/10.1016/s0021-9258(20)80672-3

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G-proteins mediate intestinal chloride channel activation

Autor: M. Kansen, J. Bijman, P. G. M. Van Gageldonk, Hans Galjaard, B. C. Tilly, N. Van Den Berghe, H. R. De Jonge

Publikováno v: Scopus-Elsevier

The localization of several GTP-binding regulatory proteins in teh apical membrane of intestinal epithelial cells has prompted us to investigate a possible role for G-proteins as modulators of apical Cl- channels. In membrane vesicles isolated from r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149e793dc97153f5ca093a5429870555
https://doi.org/10.1016/s0021-9258(18)52205-5

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