Zobrazeno 1 - 10
of 97
pro vyhledávání: '"B. C. Shanley"'
Publikováno v:
Biochemical pharmacology. 51(10)
The kinetics of the reaction of acetaldehyde (AcH) with the alpha-amino group of several di- and tripeptides to form 2-methylimidazolidin-4-one adducts were determined at pH 7, 4, 37 degrees C, using reverse phase HPLC to separate peptides from adduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f985b1d86d77d6bc4db1718d92e1f7ed
https://pubmed.ncbi.nlm.nih.gov/8787540
https://pubmed.ncbi.nlm.nih.gov/8787540
Publikováno v:
Alcohol and alcoholism (Oxford, Oxfordshire). 30(3)
Acetaldehyde, the major metabolite of ethanol, reacts with lysine and other free amino groups on proteins to form acetaldehyde-protein adducts. The presence of antibodies which recognize such acetaldehyde-protein adducts in sera from alcoholics has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd8ffb9afee037f52452df732d1229a0
https://pubmed.ncbi.nlm.nih.gov/7545992
https://pubmed.ncbi.nlm.nih.gov/7545992
Publikováno v:
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. 2
The hyperexcitability observed following ethanol withdrawal in dependent animals is thought to be related to increased sensitivity of glutamate receptors. This may predispose to 'excitotoxic' neural damage. The aim of this study was to test this hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12732eb192fc3f26e36c4310efc677d6
https://pubmed.ncbi.nlm.nih.gov/7748324
https://pubmed.ncbi.nlm.nih.gov/7748324
Publikováno v:
Biochemistry international. 26(6)
The effects of ethanol, monofluoro- and trifluoroethanol on the hydrolysis of ATP and coupled Ca2+ translocation by sarcoplasmic reticulum Ca(2+)-ATPase (EC 3.6.1.38) were measured. All three alcohols had parallel effects on the enzyme activities at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d98a5aeb052ebe27228d7413a5045df
https://pubmed.ncbi.nlm.nih.gov/1385948
https://pubmed.ncbi.nlm.nih.gov/1385948
Publikováno v:
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. 1
Rats fed ethanol for periods of 3-27 months were found to produce an immune response to acetaldehyde-modified proteins, whereas treatment for a shorter period (3 weeks) did not lead to such a response. The antibodies from the ethanol-fed animals were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b0d9478ba2b48dbe55ea6f6004793d59
https://pubmed.ncbi.nlm.nih.gov/1845545
https://pubmed.ncbi.nlm.nih.gov/1845545
Publikováno v:
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. 1
In the present study we have used an enzyme-linked immunosorbent assay to measure the immunoreactivity towards acetaldehyde-modified proteins in plasma from alcoholics, patients with non-alcoholic liver disease and control social drinkers. All three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1670502d7e099954de1f00abc3e57c76
https://pubmed.ncbi.nlm.nih.gov/1845546
https://pubmed.ncbi.nlm.nih.gov/1845546
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 252(2)
It has been proposed that ethanol and aging may interact synergistically to impair brain function through effects on central muscarinic receptors. Previous studies have investigated the effect of either chronic ethanol treatment or aging, but not bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::728496013d8f49e1013104f0e51e8fc8
https://pubmed.ncbi.nlm.nih.gov/2313603
https://pubmed.ncbi.nlm.nih.gov/2313603
Publikováno v:
Alcohol and alcoholism (Oxford, Oxfordshire). 25(5)
Several studies have recently shown the presence of antibodies against acetaldehyde-modifications in the sera of alcoholic patients. To assess the specificity of this immune response, plasma immunoreactivity with proteins modified in vitro by acetald
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79c7095ce9ab9f080384e3ea1aeaa321
https://pubmed.ncbi.nlm.nih.gov/1708257
https://pubmed.ncbi.nlm.nih.gov/1708257
Publikováno v:
Clinical Science. 53:111-115
1. The effect of hexachlorobenzene feeding on liver δ-aminolaevulinate synthase, uroporphyrinogen decarboxylase and cytochrome P450 was studied at various time-intervals in siderotic and non-siderotic rats. 2. In the non-siderotic group hexachlorobe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e515ff71b8eacd43d004390d7e434c
https://doi.org/10.1042/cs0530111
https://doi.org/10.1042/cs0530111