Zobrazeno 1 - 10
of 879
pro vyhledávání: '"B. Bowman"'
Autor:
Michael Aschner, Airton C. Martins, Gustavo H. Oliveira-Paula, Anatoly V. Skalny, Irina P. Zaitseva, Aaron B. Bowman, Anatoly A. Kirichuk, Abel Santamaria, Yousef Tizabi, Alexey A. Tinkov
Publikováno v:
Current Research in Toxicology, Vol 6, Iss , Pp 100170- (2024)
The objective of the present narrative review was to synthesize existing clinical and epidemiological findings linking manganese (Mn) exposure biomarkers to autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), and to di
Externí odkaz:
https://doaj.org/article/8cc4f74c43fa46f095043bd301798328
Autor:
Anna C. Pfalzer, Yan Yan, Hakmook Kang, Melissa Totten, James Silverman, Aaron B. Bowman, Keith Erikson, Daniel O. Claassen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The importance of metal biology in neurodegenerative diseases such as Huntingtin Disease is well documented with evidence of direct interactions between metals such as copper, zinc, iron and manganese and mutant Huntingtin pathobiology. To d
Externí odkaz:
https://doaj.org/article/e0d0afe6e7cd4cd78a38dc54fdc2a52a
Autor:
Holly N. Cukier, Hyunjin Kim, Anthony J. Griswold, Simona G. Codreanu, Lisa M. Prince, Stacy D. Sherrod, John A. McLean, Derek M. Dykxhoorn, Kevin C. Ess, Peter Hedera, Aaron B. Bowman, M. Diana Neely
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-17 (2022)
Abstract We previously reported on two brothers who carry identical compound heterozygous PRKN mutations yet present with significantly different Parkinson’s Disease (PD) clinical phenotypes. Juvenile cases demonstrate that PD is not necessarily an
Externí odkaz:
https://doaj.org/article/9cfa439da89548cd82667ecafd084ddb
Autor:
Airton C. Martins, Miriam B. Virgolini, Daiana Silva Ávila, Pablo Scharf, Jung Li, Alexey A. Tinkov, Anatoly V. Skalny, Aaron B. Bowman, João B. T. Rocha, Michael Aschner
Publikováno v:
Cells, Vol 12, Iss 17, p 2124 (2023)
Mitochondria play a crucial role in cellular respiration, ATP production, and the regulation of various cellular processes. Mitochondrial dysfunctions have been directly linked to pathophysiological conditions, making them a significant target of int
Externí odkaz:
https://doaj.org/article/1d40ef63f0b148978e059548aa3ac2af
Autor:
Airton C. Martins, Beatriz Ferrer, Alexey A. Tinkov, Samuel Caito, Romina Deza-Ponzio, Anatoly V. Skalny, Aaron B. Bowman, Michael Aschner
Publikováno v:
Toxics, Vol 11, Iss 8, p 670 (2023)
Metabolic syndrome (MetS) is an important public health issue that affects millions of people around the world and is growing to pandemic-like proportions. This syndrome is defined by the World Health Organization (WHO) as a pathologic condition char
Externí odkaz:
https://doaj.org/article/366f2ea6524340c1b2102a73c59098dc
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1229 (2023)
The insulin-like growth factor (IGF)/insulin signaling (IIS) pathway is involved in cellular responses against intracellular divalent manganese ion (Mn2+) accumulation. As a pathway where multiple nodes utilize Mn2+ as a metallic co-factor, how the I
Externí odkaz:
https://doaj.org/article/53fc003f215a4e938a512c8312cb6043
Autor:
Sana Tabbassum, Pinjing Cheng, Frank M. Yanko, Rekha Balachandran, Michael Aschner, Aaron B. Bowman, Linda H. Nie
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Potassium is known for its effect on modifiable chronic diseases like hypertension, cardiac disease, diabetes (type-2), and bone health. In this study, a new method, neutron generator based neutron activation analysis (NAA), was utilized to
Externí odkaz:
https://doaj.org/article/f3810f8064d1477eae0af8d2b253f9e0
Autor:
Tao Ke, Félix Alexandre Antunes Soares, Abel Santamaría, Aaron B. Bowman, Anatoly V. Skalny, Michael Aschner
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 930-937 (2020)
N,N’ bis-(2-mercaptoethyl) isophthalamide (NBMI) is a lipophilic thiol-containing agent that has high affinity for toxic metal ions, such as Hg2+, Pb2+, and Cd2+. Studies have shown that NBMI is a potent chelator of heavy metals, yet its potential
Externí odkaz:
https://doaj.org/article/2067e2270bb248739c247d213bf90227
Autor:
Tao Ke, Alexey A. Tinkov, Anatoly V. Skalny, Abel Santamaria, Joao B. T. Rocha, Aaron B. Bowman, Wen Chen, Michael Aschner
Publikováno v:
Toxics, Vol 11, Iss 1, p 72 (2023)
MeHg is an environmental neurotoxin that can adversely affect the development of the nervous system. The molecular integrity of chromatin in the nucleus is an important target of MeHg. Low levels of MeHg trigger epigenetic mechanisms that may be invo
Externí odkaz:
https://doaj.org/article/06fae003f4d54898b7ede34a4c3e2fd5
Autor:
Emma H. Neal, Nicholas A. Marinelli, Yajuan Shi, P. Mason McClatchey, Kylie M. Balotin, Dalton R. Gullett, Kameron A. Hagerla, Aaron B. Bowman, Kevin C. Ess, John P. Wikswo, Ethan S. Lippmann
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1380-1388 (2019)
Summary: Human induced pluripotent stem cell (iPSC)-derived developmental lineages are key tools for in vitro mechanistic interrogations, drug discovery, and disease modeling. iPSCs have previously been differentiated to endothelial cells with blood-
Externí odkaz:
https://doaj.org/article/2fec50b5cb49448e9a5ab0b94824d7b3