Zobrazeno 1 - 10
of 236
pro vyhledávání: '"B. Bolen"'
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 34K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd0a58f7cbd736328e57e7a23f7e5ec
https://doi.org/10.1158/1078-0432.22446309.v1
https://doi.org/10.1158/1078-0432.22446309.v1
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
Purpose: Small-molecule inhibitors of Aurora A (AAK) and B (ABK) kinases, which play important roles in mitosis, are currently being pursued in oncology clinical trials. We developed three novel assays to quantitatively measure biomarkers of AAK inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2b8c17037133a1bc1c17abc8089fa3
https://doi.org/10.1158/1078-0432.c.6520713
https://doi.org/10.1158/1078-0432.c.6520713
Autor:
Siegfried Janz, Brian Van Ness, Joseph B. Bolen, Mark Manfredi, Erik Kupperman, Allison J. Berger, Vishala T. Neppalli, Mary Carsillo, Paul Hales, Ping Li, Olga Tayber, Zhi Li, Michael Pickard, Ray Liu, Matthew D. Silva, Ozlem Subakan, Daniel P. Bradley, Jennifer Terkelsen, Kristen Bano, Jill Donelan, Bret Bannerman, Michael Fitzgerald, Edmund C. Lee
Purpose: The clinical success of the first-in-class proteasome inhibitor bortezomib (VELCADE) has validated the proteasome as a therapeutic target for treating human cancers. MLN9708 is an investigational proteasome inhibitor that, compared with bort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf51cd992431bfa10c2e6773dbd8053
https://doi.org/10.1158/1078-0432.c.6520107
https://doi.org/10.1158/1078-0432.c.6520107
Autor:
Siegfried Janz, Brian Van Ness, Joseph B. Bolen, Mark Manfredi, Erik Kupperman, Allison J. Berger, Vishala T. Neppalli, Mary Carsillo, Paul Hales, Ping Li, Olga Tayber, Zhi Li, Michael Pickard, Ray Liu, Matthew D. Silva, Ozlem Subakan, Daniel P. Bradley, Jennifer Terkelsen, Kristen Bano, Jill Donelan, Bret Bannerman, Michael Fitzgerald, Edmund C. Lee
PDF file - 108K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fd400a1ca08e8405e5d218dd1e0d4b
https://doi.org/10.1158/1078-0432.22444227.v1
https://doi.org/10.1158/1078-0432.22444227.v1
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 27K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889d43f96b1d811fca5e3c164e018a19
https://doi.org/10.1158/1078-0432.22446306
https://doi.org/10.1158/1078-0432.22446306
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 65K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9737acec25fe2137ea4f1aa5f53a36c5
https://doi.org/10.1158/1078-0432.22446312.v1
https://doi.org/10.1158/1078-0432.22446312.v1
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 36K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fa6e54e4641152cddff0837b8a5697
https://doi.org/10.1158/1078-0432.22446315
https://doi.org/10.1158/1078-0432.22446315
Autor:
Andrew X. Chen, Arijit Chakravarty, Christopher J. Zopf, Wen Chyi Shyu, Joseph B. Bolen, Jerome T. Mettetal, Santhosh Palani
BackgroundThe effectiveness of many targeted therapies is limited by toxicity and the rise of drug resistance. A growing appreciation of the inherent redundancies of cancer signaling has led to a rise in the number of combination therapies under deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0eb07124c0dce12d7ec53255c1334c5
https://doi.org/10.1101/2020.07.01.159657
https://doi.org/10.1101/2020.07.01.159657
Autor:
Todd B. Sells, Ryan Chau, Jeffrey A. Ecsedy, Rachel E. Gershman, Kara Hoar, Jessica Huck, David A. Janowick, Vivek J. Kadambi, Patrick J. LeRoy, Matthew Stirling, Stephen G. Stroud, Tricia J. Vos, Gabriel S. Weatherhead, Deborah R. Wysong, Mengkun Zhang, Suresh K. Balani, Joseph B. Bolen, Mark G. Manfredi, Christopher F. Claiborne
Publikováno v:
ACS Medicinal Chemistry Letters. 6:630-634
The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1e3554ee794f02a6c0132d005f741f
https://doi.org/10.1021/ml500409n
https://doi.org/10.1021/ml500409n
Autor:
Vaishali Shinde, Stephen G. Stroud, Melissa S. Germanos, Mengkun Zhang, Wei Chen, Sells Todd B, Deborah R. Wysong, Arijit Chakravarty, Matthew D. Silva, Marc L. Hyer, Mark Manfredi, Christopher F. Claiborne, Jeffrey Ecsedy, Patrick J. LeRoy, Jessica Huck, Lee Silverman, David A. Janowick, Kara Hoar, Joseph B. Bolen, Rachel E. Gershman
Publikováno v:
Clinical Cancer Research. 17:7614-7624
Purpose: Small-molecule inhibitors of Aurora A (AAK) and B (ABK) kinases, which play important roles in mitosis, are currently being pursued in oncology clinical trials. We developed three novel assays to quantitatively measure biomarkers of AAK inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02bf23d8889e9b3531da6f7a6e56156
https://doi.org/10.1158/1078-0432.ccr-11-1536
https://doi.org/10.1158/1078-0432.ccr-11-1536