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S-allylcysteine inhibits chondrocyte inflammation to reduce human osteoarthritis via targeting RAGE, TLR4, JNK, and Nrf2 signaling: comparison with colchicine

Autor: Zubeyir Elmazoglu, Cem Nuri Aktekin, Berna Goker, Zehra Aydın Bek, Candan Ozogul, Sanem Saribas, B. Bitik, Çimen Karasu

Publikováno v: Biochemistry and Cell Biology. 99:645-654

The discovery of new pharmacological agents is needed to control the progression of osteoarthritis (OA), characterized by joint cartilage damage. Human OA chondrocyte (OAC) cultures were either applied to S-allylcysteine (SAC), a sulfur-containing am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3c0294c9a07fed80abd1646e6f787d
https://doi.org/10.1139/bcb-2021-0004

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AB1418 A SYSTEMATIC REVIEW OF CURRENT RHEUMATOLOGY GUIDELINES FOR GERIATRIC PERSPECTIVES

Autor: B. Bitik, M. E. Tezcan, A. E. Yucel

Publikováno v: Annals of the Rheumatic Diseases. 81:1814.2-1815

BackgroundGeriatric population (GP) includes people over 65 years of age. GP can also be divided into the 65-75 age group and >75 age group. In the last 50 years, the proportion of the elderly in the society has increased (1). Meanwhile, GP has highe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70c32c16e64f4bb532ac9f25fc8ff1bf
https://doi.org/10.1136/annrheumdis-2022-eular.4931

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TLR4, RAGE, and p-JNK/JNK mediated inflammatory aggression in osteoathritic human chondrocytes are counteracted by redox-sensitive phenolic olive compounds: Comparison with ibuprofen

Autor: Gulistan Sanem Saribas, Zubeyir Elmazoglu, Berna Goker, Cem Nuri Aktekin, Candan Ozogul, Çimen Karasu, Zehra Aydın Bek, B. Bitik

Publikováno v: Journal of tissue engineering and regenerative medicineREFERENCES. 14(12)

Osteoarthritic chondrocytes show an over-activity of inflammatory catabolic mediators, and olive products have attracted attention because they were discovered to have some benefits on osteoarthritis patients. We investigated the mechanisms of action

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6a312c485304eb1aa8a9bafef69ca1
https://pubmed.ncbi.nlm.nih.gov/33010113

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Clinical characteristics of avascular necrosis in patients with Behçet disease: a case series and literature review

Autor: Ozkan Varan, Seminur Haznedaroglu, Nuh Atas, Abdurrahman Tufan, B. Bitik, Berna Goker, Hakan Babaoglu, Mehmet Akif Ozturk

Publikováno v: Rheumatology International. 39:153-159

Avascular necrosis (AVN), also known as osteonecrosis, is characterized by death of the osteocytes due to inadequate blood supply caused by various mechanisms. The hip is the most common affected joint followed by knee. Incidence of AVN in rheumatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67221d5d95aa429bc76b1e1c024809a
https://doi.org/10.1007/s00296-018-4224-9

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Standardized extract of Olea europaea leaves suppresses pro-inflammatory cytokines through regulating redox signaling pathways in human chondrocytes

Autor: Cem Nuri Aktekin, Zehra Aydın Bek, B. Bitik, Zubeyir Elmazoglu, Çimen Karasu, Berna Goker

Publikováno v: Osteoarthritis and Cartilage. 28:S105-S106

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a084817132a87b67c509d634c5212da
https://doi.org/10.1016/j.joca.2020.02.169

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Colchicine Provides Chondrocyte Survival As A Redox Modulator In Human Osteoarthritis

Autor: Berna Goker, Cem Nuri Aktekin, Çimen Karasu, Zubeyir Elmazoglu, Dilek Yapar, B. Bitik

Öz bulunamadı.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401e8079a98762b2d447cafda26742c2
https://aperta.ulakbim.gov.tr/record/7023

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AB0107 S-ALLYL-L-CYSTEINE ATTENUATES INFLAMMATION RELATED OXIDATIVE STRESS PARAMETERS AND INCREASES ADHESION CAPACITY OF PRIMARY HUMAN OSTEOARTHRITIC ARTICULAR CHONDROCYTES

Autor: Çimen Karasu, Zubeyir Elmazoglu, Zehra Aydın Bek, B. Bitik, Berna Goker, Cem Nuri Aktekin, Mehmet Engin Tezcan

Publikováno v: Abstracts Accepted for Publication.

Background: Osteoarthritis (OA) is characterized by progressive destruction of the articular cartilage, and chondrocytes, the only cells in articular cartilage, are in charge of maintaining the homeostasis of articular cartilage via modulating extrac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5aba003eea91013b8c0bbed0b2d9f19a
https://doi.org/10.1136/annrheumdis-2019-eular.6046

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Akademický článek

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AB0464 THE ROLE OF CYCLOPHOSPHAMIDE CHEMOTHERAPY IN THE TREATMENT OF EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS

Autor: B. Bitik, D. Kaskari, Müge Aydın, G. Sahin Dalgic, Ahmet Eftal Yücel

Publikováno v: Annals of the Rheumatic Diseases. 79:1530.2-1531

Background:Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare type of ANCA associated Vasculitis (AAVs). Cyclophosphamide (CYC) is generally recommended for the induction of remission in life/organ threatening AAVs in combination with glu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c32fad1581ac0652e212f1788d2c098
https://doi.org/10.1136/annrheumdis-2020-eular.6481

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