Zobrazeno 1 - 10
of 94
pro vyhledávání: '"B. Bennion"'
Autor:
Kelsey B. Bennion, Danya Liu, Abdelhameed S. Dawood, Megan M. Wyatt, Katie L. Alexander, Mohamed S. Abdel-Hakeem, Chrystal M. Paulos, Mandy L. Ford
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The regulatory circuits dictating CD8+ T cell responsiveness versus exhaustion during anti-tumor immunity are incompletely understood. Here we report that tumor-infiltrating antigen-specific PD-1+ TCF-1− CD8+ T cells express the immunosupp
Externí odkaz:
https://doaj.org/article/ac5c51a14c4148dcaf211da0aa6ca675
Autor:
Chrystal M Paulos, Megan M Wyatt, Kelsey B Bennion, Danya Liu, Abdelhameed Dawood, Mosalah S Abdel-Hakeem, Mandy L Ford
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/91b6213a08394b59b81e424f942a1a9d
Autor:
Clara R. Farley, Anna B. Morris, Marvi Tariq, Kelsey B. Bennion, Sayalee Potdar, Ragini Kudchadkar, Michael C. Lowe, Mandy L. Ford
Publikováno v:
JCI Insight, Vol 6, Iss 4 (2021)
In the setting of cancer, T cells upregulate coinhibitory molecules that attenuate TCR signaling and lead to the loss of proliferative capacity and effector function. Checkpoint inhibitors currently in clinical use have dramatically improved mortalit
Externí odkaz:
https://doaj.org/article/f591a64e71054e5e8edf9829dfcf3161
Publikováno v:
Immunologic Research. 68:63-70
With several different CAR T cell therapies under advanced phases of clinical trials, and the first FDA-approved CAR treatments in 2017 (Yescarta and Kymriah), CAR T cell therapy has become one of the most promising therapies for the treatment of cer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c524c0912052daa88fb7a7db042bbbd
https://doi.org/10.1007/s12026-020-09119-7
https://doi.org/10.1007/s12026-020-09119-7
Autor:
Kelsey B. Bennion, Marvi Tariq, Kirsten M. Baecher, Chrystal M. Paulos, Ragini Kudchadkar, Michael C. Lowe, Mandy L. Ford
Publikováno v:
Cancer Research. 82:594-594
In this study, we show that FcγRIIB on the surface of CD8+ T cells reduces responsiveness to αPD-1 antibody in melanoma patients, and we suggest therapeutic strategies to improve CD8+ T cell response to PD-1 blockade. Immune checkpoint blockade (IC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::913082f7108781ed8c2c3e9a182019fb
https://doi.org/10.1158/1538-7445.am2022-594
https://doi.org/10.1158/1538-7445.am2022-594
Akademický článek
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Autor:
Ragini R. Kudchadkar, Kelsey B Bennion, Michael C. Lowe, Clara R. Farley, Marvi Tariq, Mandy L. Ford, Anna B. Morris, Sayalee Potdar
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 4 (2021)
JCI Insight, Vol 6, Iss 4 (2021)
In the setting of cancer, T cells upregulate coinhibitory molecules that attenuate TCR signaling and lead to the loss of proliferative capacity and effector function. Checkpoint inhibitors currently in clinical use have dramatically improved mortalit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e998dfb5c6aee01af779b7c17491b6
https://pubmed.ncbi.nlm.nih.gov/33616086
https://pubmed.ncbi.nlm.nih.gov/33616086
Autor:
Eliza E. Bitter, Richard A. Robison, Abigail M. Felsted, Kim L. O'Neill, Kelsey B. Bennion, Michelle H. Townsend
Publikováno v:
Experimental Cell Research. 403:112567
We chose to evaluate Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) as a possible biomarker for prostate cancer due to its involvement in nucleotide synthesis and cell cycle progression. We utilized two prostate cancer cell lines (PC3 and DU14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea929abd125efd950353e70d8ef0643
https://doi.org/10.1016/j.yexcr.2021.112567
https://doi.org/10.1016/j.yexcr.2021.112567
Autor:
Gajendra Shrestha, Kim L. O'Neill, Kelsey B. Bennion, Corbin M. Lee, Michelle H. Townsend, Scott Weber, Edwin J. Velazquez, Zachary D. Ewel, Rachel A. Skabelund, Kiara V. Whitley, Kai Li Ong, Taylor D. Brindley, Richard A. Robison, Eliza E. Bitter
Publikováno v:
Cancer Research. 79:2987-2987
Our research explores the potential of a panel of monoclonal antibodies targeting the tumor proliferation biomarker Thymidine Kinase 1 (TK1) for both clinical and therapeutic applications. Cancer biomarkers have become a critical component of precisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49b0119b53bf279cd27ac3574df17ca9
https://doi.org/10.1158/1538-7445.am2019-2987
https://doi.org/10.1158/1538-7445.am2019-2987
Autor:
Michelle H. Townsend, Zachary D. Ewell, Claudia M. Tellez Freitas, Dallas J. Larsen, Eliza L. Bitter, Kelsey B. Bennion, Stephen R. Piccolo, K Scott Weber, Richard A. Robison, Kim L. O'Neill
Publikováno v:
Cancer Research. 79:2369-2369
The purpose of this study was to examine the possible effects that Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) may have on the immune response in the tumor microenvironment. HPRT is a salvage pathway enzyme responsible for recycling guanosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83c476d77340cd0360b4ca1f126c58cc
https://doi.org/10.1158/1538-7445.am2019-2369
https://doi.org/10.1158/1538-7445.am2019-2369