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Potassium Ions Enhance Guanine Radical Generation upon Absorption of Low-Energy Photons by G-Quadruplexes and Modify Their Reactivity

Autor: Lara Martínez-Fernández, Akos Banyasz, B. Behmand, Dimitra Markovitsi, Roberto Improta, Gérard Baldacchino, Evangelos Balanikas

Publikováno v: Journal of Physical Chemistry Letters
Journal of Physical Chemistry Letters, 2020, 11 (4), pp.1305-1309. ⟨10.1021/acs.jpclett.0c00815⟩
The Journal of Physical Chemistry Letters
Journal of Physical Chemistry Letters, American Chemical Society, 2020, 11 (4), pp.1305-1309. ⟨10.1021/acs.jpclett.0c00815⟩
Journal of Physical Chemistry Letters, American Chemical Society, 2020, pp.1305-1309. ⟨10.1021/acs.jpclett.9b03667⟩
Journal of Physical Chemistry Letters, 2020, pp.1305-1309. ⟨10.1021/acs.jpclett.9b03667⟩

International audience; G-Quadruplexes are formed by guanine rich DNA/RNA sequences in the presence of metal ions, which occupy the central cavity of these four-stranded structures. We show that these metal ions have a significant effect on the photo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b2424bca1780dee3be2159c9dfa739
https://cea.hal.science/cea-03053797/document

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OC-0048 Correlation between radiation-induced foci from 192Ir brachytherapy and tumor nuclei Size

Autor: Y Kamio, S. Abbasinejad Enger, Michael D.C. Evans, B. Behmand

Publikováno v: Radiotherapy and Oncology. 158:S37-S38

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5588ddbdf3c9ee7a7637747388c0903
https://doi.org/10.1016/s0167-8140(21)06290-3

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Radiosensitization of DNA by Cisplatin Adducts Results from an Increase in the Rate Constant for the Reaction with Hydrated Electrons and Formation of PtI

Autor: J. R. Wagner, Mehran Mostafavi, Léon Sanche, Jean-Louis Marignier, Darel J. Hunting, B. Behmand

Publikováno v: The Journal of Physical Chemistry B. 119:9496-9500

Pulse radiolysis measurements of the decay of hydrated electrons in solutions containing different concentrations of the oligonucleotide GTG with and without a cisplatin adduct show that the presence of a cisplatin moiety accelerates the reaction bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa5095b8c330fafae9d91f01ebe32a8
https://doi.org/10.1021/acs.jpcb.5b01752

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Hydrated Electrons React with High Specificity with Cisplatin Bound to Single-Stranded DNA

Autor: Pierre Cloutier, B. Behmand, J. R. Wagner, Darel J. Hunting, Léon Sanche, Sonia Girouard

Publikováno v: The Journal of Physical Chemistry B. 117:15994-15999

Short oligonucleotides TTTTTGTGTTT and TTTTTTTGTTT in solution with and without cisplatin (cisPt) bound to the guanine bases were irradiated with γ-rays at doses varying from 0 to 2500 Gy. To determine the effect of hydrated electrons from water rad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c467d9c59364a4268d3a3961782e77
https://doi.org/10.1021/jp4089904

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Cisplatin intrastrand adducts sensitize DNA to base damage by hydrated electrons

Autor: Darel J. Hunting, Léon Sanche, J. R. Wagner, B. Behmand

Publikováno v: The journal of physical chemistry. B. 118(18)

The oligonucleotide TTTTTGTGTTT with or without a cisplatin adduct was reacted with hydrated electrons generated by ionizing radiation. Hydroxyl radicals were quenched with ethylenediaminetetraacetic acid (EDTA), and the solutions were bubbled with w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27ca2de6ef70fe83ba7e91895ac324f
https://pubmed.ncbi.nlm.nih.gov/24779712

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