Zobrazeno 1 - 10
of 22
pro vyhledávání: '"B. Barry Touré"'
Autor:
Subarna Shakya, José S. Duca, Elizabeth R. Sprague, Xin Chen, Zhuoliang Chen, Carol Joud, Yaping Wang, John William Giraldes, Wenlin Shao, Simon Mathieu, Chen Christine Hiu-Tung, Yanqiu Yuan, Kristen Hurov, B. Barry Touré, Christopher Sean Straub
Publikováno v:
Journal of Medicinal Chemistry. 60:2155-2161
While adding the structural features that are more favored by on-target activity is the more common strategy in selectivity optimization, the opposite strategy of subtracting the structural features that contribute more to off-target activity can als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfbe2e1bd93085f79063c4dc5fd61bb
https://doi.org/10.1021/acs.jmedchem.7b00033
https://doi.org/10.1021/acs.jmedchem.7b00033
Publikováno v:
Angewandte Chemie. 128:14430-14451
Konnen klassische und moderne C-H-Oxidationsreaktionen Biotransformationen bei der Synthese von Wirkstoffmetaboliten erganzen? Wir haben versucht, bei einer Durchsicht der Literatur eine Antwort auf diese wichtige Frage fur die Praxis der pharmazeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78cb215bed1becae33e0cd4b670f3a6a
https://doi.org/10.1002/ange.201602644
https://doi.org/10.1002/ange.201602644
Autor:
Yaping Wang, Xin Chen, Zhuoliang Chen, John William Giraldes, Kirk Wright, Sean Kim, José S. Duca, Eric J. Martin, J. Tres Brazell, Kristen Hurov, Elizabeth R. Sprague, Yun Feng, David E. Puleo, Subarna Shakya, Yanqiu Yuan, David Sage, Matthew J. Meyer, Yuji Mishina, Yan Yan-Neale, Christopher Sean Straub, Li Tian, Simon Mathieu, Dongshu Chen, Wenlin Shao, B. Barry Touré, Troy Smith
Publikováno v:
Journal of Medicinal Chemistry. 59:4711-4723
MELK kinase has been implicated in playing an important role in tumorigenesis. Our previous studies suggested that MELK is involved in the regulation of cell cycle and its genetic depletion leads to growth inhibition in a subset of high MELK-expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef8110b976db9c7b26d95564840f324
https://doi.org/10.1021/acs.jmedchem.6b00052
https://doi.org/10.1021/acs.jmedchem.6b00052
Publikováno v:
Tetrahedron Letters. 56:3066-3069
We aim the power of C–H bond functionalization at a problem of major practical consequence—namely, scalable access to drug metabolites and their analogs. In this context, we pursue the development of simple C–H oxidation methods that tolerate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c429f262fa85e8b6f3246df2bedfe44
https://doi.org/10.1016/j.tetlet.2014.11.037
https://doi.org/10.1016/j.tetlet.2014.11.037
Publikováno v:
ChemInform. 47
Can classical and modern chemical C-H oxidation reactions complement biotransformation in the synthesis of drug metabolites? We have surveyed the literature in an effort to try to answer this important question of major practical significance in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e79ba25696be2a5998a1170996773fbb
https://doi.org/10.1002/chin.201651252
https://doi.org/10.1002/chin.201651252
Publikováno v:
Journal of the American Chemical Society. 135:12346-12352
The isolation, quantitation, and characterization of drug metabolites in biological fluids remain challenging. Rapid access to oxidized drugs could facilitate metabolite identification and enable early pharmacology and toxicity studies. Herein, we co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b357bb64733f195bf519ebccbcd6dd3
https://doi.org/10.1021/ja405471h
https://doi.org/10.1021/ja405471h
Autor:
Fallon Lin, Ali Farsidjani, Daniel J. McKay, Darcy Kohls, Simon van der Plas, Lindsey Rodrigues, Ming Xu, Kirk Wright, Jinyun Chen, Raviraj Kulathila, Daniel Baird, Pascal D. Fortin, YoungShin Cho, Xiaoling Xie, Julian Levell, Raymond Pagliarini, Vladimir Capka, Kimberly E. Bowen, B. Barry Touré, Gregg Chenail, David Sage, Julia Dooley, Hong Yin
Publikováno v:
Structure (London, England : 1993). 25(3)
Oncogenic IDH1 and IDH2 mutations contribute to cancer via production of R-2-hydroxyglutarate (2-HG). Here, we characterize two structurally distinct mutant- and isoform-selective IDH1 inhibitors that inhibit 2-HG production. Both bind to an alloster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e323c04dbdcb84f8a485fd20732ee01
https://pubmed.ncbi.nlm.nih.gov/28132785
https://pubmed.ncbi.nlm.nih.gov/28132785
Autor:
Fan S. Yang, Ty Gould, Ina Dix, John William Giraldes, Liping X. Zhou, Thomas Caferro, Pascal D. Fortin, Rémi Terranova, Xiaoling Xie, Fallon Lin, Joseph D. Growney, Raviraj Kulathila, Young Shin Cho, Troy Smith, Julian Levell, B. Barry Touré, Brant Firestone, Ming Xu, Simon van der Plas, Julia Dooley, Gang Liu, Trixie Wagner, Arne Mueller, Viraj Tyagi, Gregg Chenail, Kelly Slocum, Raymond Pagliarini, Michael D. Jones
Publikováno v:
ACS medicinal chemistry letters. 8(2)
High throughput screening and subsequent hit validation identified 4-isopropyl-3-(2-((1-phenylethyl)amino)pyrimidin-4-yl)oxazolidin-2-one as a potent inhibitor of IDH1R132H. Synthesis of the four separate stereoisomers identified the (S,S)-diastereom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710e67a230f22b94b21fe68fcf9fdd4a
https://pubmed.ncbi.nlm.nih.gov/28197303
https://pubmed.ncbi.nlm.nih.gov/28197303
Publikováno v:
Angewandte Chemie (International ed. in English). 55(46)
Can classical and modern chemical C-H oxidation reactions complement biotransformation in the synthesis of drug metabolites? We have surveyed the literature in an effort to try to answer this important question of major practical significance in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba800435f607ace1aa5f46b6fc25437
https://pubmed.ncbi.nlm.nih.gov/27723189
https://pubmed.ncbi.nlm.nih.gov/27723189
Publikováno v:
Organic Letters. 12:1532-1535
We describe the coupling of primary sulfonamides and various halogenated heterocyclic cores, with an emphasis on 2-heteroaryl halides, via copper catalysis. These studies enabled the synthesis of many new mono-N-heteroaryl sulfonamides. The electroni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23f7bab9a579f2373ed53821f87162e
https://doi.org/10.1021/ol100263r
https://doi.org/10.1021/ol100263r