Zobrazeno 1 - 10 of 267 pro vyhledávání: '"B. Bacon"'
1
Akademický článek
Image Restoration and Analysis of Influenza Virions Binding to Membrane Receptors Reveal Adhesion-Strengthening Kinetics.
Autor: Donald W Lee, Hung-Lun Hsu, Kaitlyn B Bacon, Susan Daniel
Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0163437 (2016)
With the development of single-particle tracking (SPT) microscopy and host membrane mimics called supported lipid bilayers (SLBs), stochastic virus-membrane binding interactions can be studied in depth while maintaining control over host receptor typ
Externí odkaz: https://doaj.org/article/0f48a4a7dc9643c8a5d2d2819c8d57af
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2
Akademický článek
MAP3K19 Is a Novel Regulator of TGF-β Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis.
Autor: Stefen A Boehme, Karin Franz-Bacon, Danielle N DiTirro, Tai Wei Ly, Kevin B Bacon
Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0154874 (2016)
Idiopathic pulmonary fibrosis (IPF) is a progressive, debilitating disease for which two medications, pirfenidone and nintedanib, have only recently been approved for treatment. The cytokine TGF-β has been shown to be a central mediator in the disea
Externí odkaz: https://doaj.org/article/38055d636c7843c8825acf55b31e768b
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3
Akademický článek
MAP3K19 Is Overexpressed in COPD and Is a Central Mediator of Cigarette Smoke-Induced Pulmonary Inflammation and Lower Airway Destruction.
Autor: Stefen A Boehme, Karin Franz-Bacon, John Ludka, Danielle N DiTirro, Tai Wei Ly, Kevin B Bacon
Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0167169 (2016)
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and lung inflammation resulting in a progressive decline in lung function whose principle cause is cigarette smoke. MAP3K19 is a novel kinase expressed pre
Externí odkaz: https://doaj.org/article/95344ca64b304d05af4f2cf8aefbe57d
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4
Akademický článek
PAR-2 Deficient CD4+ T Cells Exhibit Downregulation of IL-4 and Upregulation of IFN-γ after Antigen Challenge in Mice
Autor: Michitaka Shichijo, Shinichi Kondo, Mina Ishimori, Shinichi Watanabe, Heidi Helin, Tsugiko Yamasaki, Mary E Stevens, Florian Gantner, Kevin B Bacon
Publikováno v: Allergology International, Vol 55, Iss 3, Pp 271-278 (2006)
Background: To investigate the functional role of protease activated receptor (PAR) -2 in T lymphocytes, we analyzed TCR-mediated inflammatory cytokine production using PAR-2 deficient (KO) and wild type (WT) mice. Methods: Production of serum IgE an
Externí odkaz: https://doaj.org/article/39843e3c18dd46c38ca10ccc9dfbf58e
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5
Targeting MAP3K19 prevents human lung myofibroblast activation both in vitro and in a humanized SCID model of idiopathic pulmonary fibrosis
Autor: Milena S. Espindola, David M. Habiel, Rohan Narayanan, Kevin B. Bacon, Cory M. Hogaboam, Isabelle Jones, Stefen A. Boehme, Ana Lucia Coelho, Tai Wei Ly
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Idiopathic Pulmonary Fibrosis (IPF) is a disease with a devastating prognosis characterized by unrelenting lung scarring. Aberrant activation of lung fibroblasts is a key feature of this disease, yet the key pathways responsible for this are poorly u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f05e1e46e899a82ddb209b3a9cc4c6
http://link.springer.com/article/10.1038/s41598-019-56393-z
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6
The effects of a CCR3 inhibitor, AXP1275, on allergen-induced airway responses in adults with mild-to-moderate atopic asthma
Autor: Gail M. Gauvreau, Linda Hui, JM FitzGerald, S Boehme, Abbey Schlatman, J Kum, Richard M. Watson, Paul M. O'Byrne, L.-P. Boulet, Caitlin Obminski, K B Bacon, H Villineuve, Tara Scime, T W Ly
Publikováno v: Clinical & Experimental Allergy. 48:445-451
Background CCR3 is the cognate receptor for major human eosinophil chemoattractants from the eotaxin family of proteins that are elevated in asthma and correlate with disease severity. Objective This proof-of-mechanism study examined the effect of AX
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceccb3b94218ab4df4d80b50d8550a4b
https://doi.org/10.1111/cea.13114
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8
Akademický článek
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9
Single-Particle Tracking Shows that a Point Mutation in the Carnivore Parvovirus Capsid Switches Binding between Host-Specific Transferrin Receptors
Autor: Susan Daniel, Kaitlyn B. Bacon, Andrew B. Allison, Donald W. Lee, Colin R. Parrish
Publikováno v: Journal of Virology. 90:4849-4853
Determining how viruses infect new hosts via receptor-binding mechanisms is important for understanding virus emergence. We studied the binding kinetics of canine parvovirus (CPV) variants isolated from raccoons—a newly recognized CPV host—to dif
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b37a3a738fa9836638fac85d4a029d
https://doi.org/10.1128/jvi.03204-15
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Plný text Recenzováno Digitální knihovna AV ČR
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