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pro vyhledávání: '"B. B. Aggarwal"'
Autor:
B. B. Aggarwal
Publikováno v:
Acta Horticulturae. :33-46
Publikováno v:
Leukemia. 17:2196-2201
Epstein-Barr virus (EBV)-immortalized lymphoblastoid cells express high levels of lymphotoxin and use this molecule as an autocrine growth factor. We hypothesized that the EBV-derived latent membrane protein 1 (LMP1) mediates lymphotoxin production b
Publikováno v:
The Journal of Immunology. 157:2410-2417
Human TNF is a highly pleiotropic cytokine that mediates its effects by binding to two distinct receptors, viz p60 and p80, which transmit their signals independently of each other. Activation of the transcription factor NF-kappa B is one of the earl
Publikováno v:
The Journal of Immunology. 157:297-304
Previously we have shown that treatment of ML-1a cells with TNF in the presence of cycloheximide triggers apoptosis within 90 min. In the present report we used this system to investigate the role of ceramide in TNF action. We found that while maximu
Publikováno v:
Cell Death & Disease
Curcumin is one of the most successful compounds investigated in recent years, and is currently being assessed both for prevention and treatment of cancer.1 Curcumin can exist in at least two tautomeric forms, keto and enol. The enol form is more ene
Autor:
L Zhang, B B Aggarwal
Publikováno v:
The Journal of Immunology. 153:3745-3754
The interaction of different polypeptide growth factors with their cell surface receptors, which are typically rich in cysteine, is modulated by sulfhydryl (SH) reagents. Because the extracellular domain of both human TNFRs are likewise rich in cyste
Publikováno v:
The Journal of Immunology. 153:2248-2257
TNF binds to two distinct receptors designated p60 and p80. Because Abs to the p60 receptor (anti-p60) can mimic TNF, we therefore compared the cellular signaling of TNF with that of anti-p60. We demonstrate both qualitative and quantitative differen
Autor:
M Higuchi, B B Aggarwal
Publikováno v:
The Journal of Immunology. 152:4017-4025
Two different types of TNF receptors, the p60 receptor with a molecular mass of 60 kDa and the p80 receptor with a mass of 80 kDa, have been identified. TNF exhibits a wide variety of biologic actions, but which receptor is responsible for these biol
Autor:
M Higuchi, B B Aggarwal
Publikováno v:
The Journal of Immunology. 152:3550-3558
As is true for other peptide hormones, TNF causes the down-modulation of its own receptor. The process by which down-regulation occurs and the particular role of each of two recently identified receptors, however, are not understood. In this report w
Publikováno v:
The Journal of Immunology. 144:3789-3794
Monocyte products including TNF and IL-1 can stimulate hemopoietic growth factor production in vitro and in vivo. Endotoxin-resistant C3H/HeJ mice have a cellular defect in the regulation of TNF production and provide a model in which to examine the