Zobrazeno 1 - 10
of 207
pro vyhledávání: '"B. Aldridge"'
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is a serious clinical challenge with high mortality rates. Antibiotic combination therapy is currently used in cases of persistent infection; however, the limited development of n
Externí odkaz:
https://doaj.org/article/73a86c822d9d4f0b8c8d26f09bc0cc9c
Autor:
Kathleen P. Davis, Yoelkys Morales, Rachel J. Ende, Ryan Peters, Anne L. McCabe, Joan Mecsas, Bree B. Aldridge
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT The rise in infections caused by multidrug-resistant (MDR) bacteria has necessitated a variety of clinical approaches, including the use of antibiotic combinations. Here, we tested the hypothesis that drug-drug interactions vary in different
Externí odkaz:
https://doaj.org/article/ad83eaa2c361452087b1a4cbb17fdadd
Autor:
Jackson P. Midtlien, Brian P. Curry, Emily Chang, Nicholas R. Kiritsis, Jennifer B. Aldridge, Kyle M. Fargen
Publikováno v:
Frontiers in Neurology, Vol 14 (2024)
BackgroundThere is increasing recognition of connective tissue disorders and their influence on disease in the general population. A conserved clinical phenotype involving connective tissue disorders and idiopathic intracranial hypertension (IIH) and
Externí odkaz:
https://doaj.org/article/205583e6c68b447dac35a0959b788c0f
Autor:
Soorya Janakiraman, Sophie Engels, Pariksheet Nanda, Maral Budak, Talia Greenstein, Mariana Pereira Moraes, Bree B. Aldridge, Denise E. Kirschner
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102442- (2023)
Summary: Biosafety level 3 decontamination precautions motivate measuring microbial colonies using consumable photography instead of expensive automated plate counters or smartphones, and assaying drug treatments–with multiple concentrations per tr
Externí odkaz:
https://doaj.org/article/a6091adfdbaf4a2785b744c1a57ce5f3
Autor:
Nastassja L. Kriel, Mae Newton-Foot, Owen T. Bennion, Bree B. Aldridge, Carolina Mehaffy, John T. Belisle, Gerhard Walzl, Robin M. Warren, Samantha L. Sampson, Nico C. Gey van Pittius
Publikováno v:
BMC Microbiology, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Bacteria require specialized secretion systems for the export of molecules into the extracellular space to modify their environment and scavenge for nutrients. The ESX-3 secretion system is required by mycobacteria for iron homeos
Externí odkaz:
https://doaj.org/article/f7bd28708a884857a23cab4bacdaac79
Autor:
Talia Greenstein, Bree B. Aldridge
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2023)
Combination therapy is necessary to treat tuberculosis to decrease the rate of disease relapse and prevent the acquisition of drug resistance, and shorter regimens are urgently needed. The adaptation of Mycobacterium tuberculosis to various lesion mi
Externí odkaz:
https://doaj.org/article/bd966980e99e40e283716cb473a8c422
Autor:
Ardeshir Goliaei, Haley A. Woods, Adriana E. Tron, Matthew A. Belmonte, J. Paul Secrist, Douglas Ferguson, Lisa Drew, Adrian J. Fretland, Bree B. Aldridge, Francis D. Gibbons
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 10, Pp 561-570 (2020)
Anticancer efficacy is driven not only by dose but also by frequency and duration of treatment. We describe a multiscale model combining cell cycle, cellular heterogeneity of B‐cell lymphoma 2 family proteins, and pharmacology of AZD5991, a potent
Externí odkaz:
https://doaj.org/article/07ad18bfe7b84642b234c602cec0a6fa
Autor:
Qingyun Liu, Junhao Zhu, Charles L. Dulberger, Sydney Stanley, Sean Wilson, Eun Seon Chung, Xin Wang, Peter Culviner, Yue J. Liu, Nathan D. Hicks, Gregory H. Babunovic, Samantha R. Giffen, Bree B. Aldridge, Ethan C. Garner, Eric J. Rubin, Michael C. Chao, Sarah M. Fortune
Publikováno v:
Science
The widespread use of antibiotics has placed bacterial pathogens under intense pressure to evolve new survival mechanisms. Genomic analysis of 51,229 Mycobacterium tuberculosis ( Mtb ) clinical isolates has identified an essential transcriptional reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d37880064609bcfc7844c5dacb52098
https://doi.org/10.1126/science.abq2787
https://doi.org/10.1126/science.abq2787
Autor:
Shuyi Ma, Suraj Jaipalli, Jonah Larkins-Ford, Jenny Lohmiller, Bree B. Aldridge, David R. Sherman, Sriram Chandrasekaran
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT The rapid spread of multidrug-resistant strains has created a pressing need for new drug regimens to treat tuberculosis (TB), which kills 1.8 million people each year. Identifying new regimens has been challenging due to the slow growth of t
Externí odkaz:
https://doaj.org/article/2e46663689eb483f82794186d5d7f4bf
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 1, p e1006774 (2019)
Drug combinations are a promising approach to achieve high efficacy at low doses and to overcome resistance. Drug combinations are especially useful when drugs cannot achieve effectiveness at tolerable doses, as occurs in cancer and tuberculosis (TB)
Externí odkaz:
https://doaj.org/article/f8fab638529b4dbc98c9eb873dab8b44