Pathological tissue formation and degradation biomarkers correlate with patient reported pain outcomes: an explorative study

Autor: Anne C. Bay-Jensen, Mukundan Attur, Jonathan Samuels, Christian S. Thudium, Steven B. Abramson, Morten A. Karsdal

Publikováno v: Osteoarthritis and Cartilage Open, Vol 5, Iss 3, Pp 100379- (2023)

Background: The lack of disease modifying drugs in Osteoarthritis (OA) may be attributed to the difficulty in robust response based on patient-reported outcomes (PROs) linked to drug mechanism of action. Joint tissue turnover biomarkers are associate

Externí odkaz: https://doaj.org/article/2f013bd017994433b08da053806363eb

Periostin loss-of-function protects mice from post-traumatic and age-related osteoarthritis

Autor: Mukundan Attur, Xin Duan, Lei Cai, Tianzhen Han, Weili Zhang, Eric D. Tycksen, Jonathan Samuels, Robert H. Brophy, Steven B. Abramson, Muhammad Farooq Rai

Publikováno v: Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-14 (2021)

Abstract Background Elevated levels of periostin (Postn) in the cartilage and bone are associated with osteoarthritis (OA). However, it remains unknown whether Postn loss-of-function can delay or prevent the development of OA. In this study, we sough

Externí odkaz: https://doaj.org/article/539326da7b6e4804afcdfd7eb108f332

Signatures of medical student applicants and academic success.

Autor: Tal Baron, Robert I Grossman, Steven B Abramson, Martin V Pusic, Rafael Rivera, Marc M Triola, Itai Yanai

Publikováno v: PLoS ONE, Vol 15, Iss 1, p e0227108 (2020)

The acceptance of students to a medical school places a considerable emphasis on performance in standardized tests and undergraduate grade point average (uGPA). Traditionally, applicants may be judged as a homogeneous population according to simple q

Externí odkaz: https://doaj.org/article/1ee40887f4fa40299eb8ea4263692c24

Basal Infusion versus Automated Boluses and a Delayed Start Timer for 'Continuous' Sciatic Nerve Blocks after Ambulatory Foot and Ankle Surgery: A Randomized Clinical Trial

Autor: John J, Finneran, Engy T, Said, Brian P, Curran, Matthew W, Swisher, Jessica R, Black, Rodney A, Gabriel, Jacklynn F, Sztain, Wendy B, Abramson, Brenton, Alexander, Michael C, Donohue, Adam, Schaar, Brian M, Ilfeld

Publikováno v: Anesthesiology. 136:970-982

Background The common technique using a basal infusion for an ambulatory continuous peripheral nerve blocks frequently results in exhaustion of the local anesthetic reservoir before resolution of surgical pain. This study was designed to improve and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f819045e44832d5751ada7188a1fbb
https://doi.org/10.1097/aln.0000000000004189

A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis

Autor: Anne-Christine Bay-Jensen, Mukundan Attur, Morten A. Karsdal, Steven B. Abramson, Yunyun Luo, Yi He, Svetlana Krasnokutsky, Inger Byrjalsen, Virginia B. Kraus, Jonathan Samuels

Publikováno v: Journal of Orthopaedics and Traumatology, Vol 22, Iss 1, Pp 1-11 (2021)
Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology

Background Osteoarthritis (OA) is a disease with multiple endotypes. A hallmark of OA is loss of cartilage; however, it is evident that the rate of cartilage loss differs among patients, which may partly be attributed to differential capacity for car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758d409a26961d21c40e7d475b45d330
https://doaj.org/article/fe780c80254c4b1aad37ba8138ac360d