Výsledky vyhledávání - "B. A. OHLSON"

Inhibitory effects of halothane on the thermogenic pathway in brown adipocytes: localization to adenylyl cyclase and mitochondrial fatty acid oxidation

Autor: Sten G. E. Lindahl, Kerstin B. E. Ohlson, Emma C. Backlund, G. E. Bronnikov, Jan Nedergaard, Nina Mohell, Barbara Cannon, Irina G. Shabalina, Katarina Lennström

Publikováno v: Biochemical Pharmacology. 68:463-477

Volatile anesthetics such as halothane efficiently inhibit nonshivering thermogenesis as well as the cellular manifestation of that phenomenon: norepinephrine-induced respiration in brown adipocytes. To identify the molecular site(s) of action of suc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef2c47a58558eb5a6661ad7e0cba8c0
https://doi.org/10.1016/j.bcp.2004.03.028

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Thermogenic Responses in Brown Fat Cells Are Fully UCP1-dependent

Autor: Anita Matthias, Jan Nedergaard, Barbara Cannon, Anders Jacobsson, Kerstin B. E. Ohlson, J. M. Fredriksson

Publikováno v: Journal of Biological Chemistry. 275:25073-25081

To examine the thermogenic significance of the classical uncoupling protein-1 (UCP1), the thermogenic potential of brown adipocytes isolated from UCP1-ablated mice was investigated. Ucp1(-/-) cells had a basal metabolic rate identical to wild-type; t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6d86b0e9dcfa0e70db5bf0f7c447080
https://doi.org/10.1074/jbc.m000547200

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Thermogenesis in Brown Adipocytes Is Inhibited by Volatile Anesthetic Agents A Factor Contributing to Hypothermia in Infants?

Autor: Nina Mohell, Sten G. E. Lindahl, Barbara Cannon, Jan Nedergaard, Kerstin B. E. Ohlson

Publikováno v: Scopus-Elsevier

In infants, nonshivering thermogenesis from brown adipose tissue provides an important source of heat for thermoregulation. Infants are known to have a high susceptibility to hypothermia during anesthesia. To investigate whether this could be due to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9eefbe949cc84e977825346638498c3
https://doi.org/10.1097/00000542-199407000-00024

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Thermogenesis inhibition in brown adipocytes is a specific property of volatile anesthetics

Autor: Sten G. E. Lindahl, Barbara Cannon, Jan Nedergaard, Kerstin B. E. Ohlson

Publikováno v: Anesthesiology. 98(2)

Background This investigation examined the possibility that the inhibitory effect of halothane on nonshivering thermogenesis (heat production) in brown adipocytes is not a universal effect of all anesthetic agents but related to the type of anestheti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942d487e7d01a8f242cec5c34d81d8fe
https://pubmed.ncbi.nlm.nih.gov/12552204

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Is there a Life in the Cold without UCP1? Uncoupling Proteins and Thermoregulatory Thermogenesis

Autor: Jan Nedergaard, Kerstin B. E. Ohlson, Barbara Cannon, Anders Jacobsson, Anita Matthias, Valeria Golozoubova

Publikováno v: Life in the Cold ISBN: 9783642086823

The original uncoupling protein UCP1 (thermogenin) is only found in brown adipose tissue which is only found in mammals. UCP1 is supposed to be the molecular basis for nonshivering thermogenesis. This tenet can be tested in the UCP1-ablated mice now

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::393ee1ae102e61736ad7f54aef965ebf
https://doi.org/10.1007/978-3-662-04162-8_42

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Analysis of the cellular mechanism for halothane inhibition of brown adipose tissue thermogenesis

Autor: Sten G. E. Lindahl, Kerstin B. E. Ohlson, Barbara Cannon, Jan Nedergaard

Publikováno v: Annals of the New York Academy of Sciences. 813

In the present studies, halothane is demonstrated to have a general inhibitory effect on norepinephrine-induced cAMP accumulation, lipolysis and rate of oxygen consumption, but no obvious effect on the respiratory capacity of isolated mitochondria. F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994bb47e6d8abdb17e6382dfd253a1f6
https://pubmed.ncbi.nlm.nih.gov/9100961

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Halothane selectively inhibits nonshivering thermogenesis. Possible implications for thermoregulation during anesthesia of infants

Autor: Jan Nedergaard, Sten G. E. Lindahl, Lennart Johnson, Andrea Dicker, Kerstin B. E. Ohlson, Barbara Cannon

Publikováno v: Anesthesiology. 82(2)

BACKGROUND During halothane anesthesia, infants fail to increase oxygen consumption in response to a cold stimulus in the form of an increase in temperature gradient between body and environment. Based on recent observations with isolated brown-fat c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a50de8f3a4410dbaeda48f37ba8d5bf
https://pubmed.ncbi.nlm.nih.gov/7856907

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