Zobrazeno 1 - 10
of 42
pro vyhledávání: '"B. A. Moroson"'
Publikováno v:
Journal of Biological Chemistry. 271:2225-2233
We report here the cloning and sequencing of the cDNA, purification, steady state kinetic analysis, and truncation mapping studies of the human 5-aminoimidazole- 4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (AICARFT/IMPCHase). Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a784294d053b437e3b97a212fb54b93
https://doi.org/10.1074/jbc.271.4.2225
https://doi.org/10.1074/jbc.271.4.2225
Autor:
A K Smith, Arlene R. Cashmore, Giuseppe Pizzorno, B. A. Moroson, M Marling-Cason, B A Kamen, G. P. Beardsley, A.D. Cross
Publikováno v:
Journal of Biological Chemistry. 268:1017-1023
5,10-Dideazatetrahydrolic acid (DDATHF) is representative of a new class of antifolates acting through inhibition of de novo purine synthesis. We report here the transport characteristics of the diastereomers of DDATHF, which differ in configuration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::381357cc554b80068d798f08362251db
https://doi.org/10.1016/s0021-9258(18)54035-7
https://doi.org/10.1016/s0021-9258(18)54035-7
Autor:
Marcella Coronnello, Stefania Carotti, Teresita Mazzei, Alessandra Gerli, Joseph R. Bertino, B. A. Moroson, Piero Periti, A. Pesciullesi, Enrico Mini
Publikováno v:
Journal of Chemotherapy. 2:17-27
Although 5-fluorouracil (FUra) is one of the most effective cytotoxic agents in the treatment of various solid tumors (carcinomas of the gastro-intestinal tract, breast, head and neck), remissions occur in only 20 to 30% of cases and usually are of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2eda046ad5756936b73d74952b817c
https://doi.org/10.1080/1120009x.1990.11739000
https://doi.org/10.1080/1120009x.1990.11739000
Autor:
G P, Beardsley, E A, Rayl, K, Gunn, B A, Moroson, H, Seow, K S, Anderson, J, Vergis, K, Fleming, S, Worland, B, Condon, J, Davies
Publikováno v:
Advances in experimental medicine and biology. 431
1. The human pur H (ATIC) gene encoding a bifunctional protein, hPurH, which carries the penultimate and final enzymatic activities of the purine nucleotide synthesis pathway, AICARFTIMPCH, has been cloned and sequenced. The gene product, hPurH has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c9f5ead17477d4873ee8e5b4cf427ec
https://pubmed.ncbi.nlm.nih.gov/9598063
https://pubmed.ncbi.nlm.nih.gov/9598063
Autor:
Brad Condon, Steven Worland, B. A. Moroson, Jay Davies, Helen A. Seow, Elizabeth A. Rayl, James M. Vergis, Karen G. Fleming, Karen Gunn, G. Peter Beardsley, Karen S. Anderson
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461374565
In both prokaryotic and eukaryotic cells the pur H gene encodes a bifunctional protein which carries the penultimate and the final activities of the de novo purine nucleotide biosynthetic pathway. These two steps are shown in Figure 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f5c4fc5ffaae93357e590f5238e5723
https://doi.org/10.1007/978-1-4615-5381-6_43
https://doi.org/10.1007/978-1-4615-5381-6_43
Autor:
C, Shih, V J, Chen, L S, Gossett, S B, Gates, W C, MacKellar, L L, Habeck, K A, Shackelford, L G, Mendelsohn, D J, Soose, V F, Patel, S L, Andis, J R, Bewley, E A, Rayl, B A, Moroson, G P, Beardsley, W, Kohler, M, Ratnam, R M, Schultz
Publikováno v:
Cancer research. 57(6)
N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl ]-benzoyl]-L-glutamic acid (LY231514) is a novel pyrrolo[2,3-d]pyrimidine-based antifolate currently undergoing extensive Phase II clinical trials. Previous studies have establi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0225038e454981676e617741fec3d59
https://pubmed.ncbi.nlm.nih.gov/9067281
https://pubmed.ncbi.nlm.nih.gov/9067281
Publikováno v:
The Journal of biological chemistry. 271(4)
We report here the cloning and sequencing of the cDNA, purification, steady state kinetic analysis, and truncation mapping studies of the human 5-aminoimidazole- 4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (AICARFT/IMPCHase). Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::522dfc17c7f6a38df6c88a36d1478298
https://pubmed.ncbi.nlm.nih.gov/8567683
https://pubmed.ncbi.nlm.nih.gov/8567683
Autor:
G, Pizzorno, B A, Moroson, A R, Cashmore, O, Russello, J R, Mayer, J, Galivan, M A, Bunni, D G, Priest, G P, Beardsley
Publikováno v:
Cancer research. 55(3)
5,10-dideaza-5,6,7,8-terrahydrofolic acid (DDATHF) is a potent antiproliferative agent in cell culture systems and in vivo in a number of murine and human xenograft tumors. In contrast to classical antifolates, which are dihydrofolate reductase inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ce724b759dc1d0ac0627877813fe547
https://pubmed.ncbi.nlm.nih.gov/7834626
https://pubmed.ncbi.nlm.nih.gov/7834626
Autor:
G, Pizzorno, A R, Cashmore, B A, Moroson, A D, Cross, A K, Smith, M, Marling-Cason, B A, Kamen, G P, Beardsley
Publikováno v:
The Journal of biological chemistry. 268(2)
5,10-Dideazatetrahydrolic acid (DDATHF) is representative of a new class of antifolates acting through inhibition of de novo purine synthesis. We report here the transport characteristics of the diastereomers of DDATHF, which differ in configuration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b507d5d61d246dcaa4c5ccf32b5b4535
https://pubmed.ncbi.nlm.nih.gov/8419310
https://pubmed.ncbi.nlm.nih.gov/8419310
Publikováno v:
Cancer research. 51(9)
(6R)-5,10-Dideaza-5,6,7,8-tetrahydrofolic acid [(6R)DDATHF] is a folate antimetabolite with activity specifically directed against de novo purine synthesis, primarily through inhibition of glycinamide ribonucleotide transformylase. This inhibition re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31a9fddd92c15a3e23821e31793d4e19
https://pubmed.ncbi.nlm.nih.gov/1707749
https://pubmed.ncbi.nlm.nih.gov/1707749