Zobrazeno 1 - 10
of 24
pro vyhledávání: '"B. A. J. Ponder"'
Autor:
Doug Easton, Paula L. Smith, Fabienne Lesueur, G Dew, Alison M. Dunning, Paul D.P. Pharoah, Patrick R. Benusiglio, Robert Luben, Don M. Conroy, Clare Jordan, B. A. J. Ponder
Publikováno v:
British Journal of Cancer
ERBB2 is frequently amplified in breast tumours as part of a wide region of amplification on chromosome 17q21. This amplicon contains many candidate genes for breast cancer susceptibility. We used a genetic association study design to determine if co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb38331992612acb64bbd6bdfb25bba
http://europepmc.org/articles/PMC2360759
http://europepmc.org/articles/PMC2360759
Autor:
Mikkel Z. Oestergaard, B. A. J. Ponder, Doug Easton, Arancha Cebrián, Tyrer Jp, Mitul Shah, Paul D.P. Pharoah, Alison M. Dunning
Publikováno v:
British Journal of Cancer
The aim of the study is to examine the association between multilocus genotypes across 10 genes encoding proteins in the antioxidant defence system and breast cancer. The 10 genes are SOD1, SOD2, GPX1, GPX4, GSR, CAT, TXN, TXN2, TXNRD1 and TXNRD2. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0f3a5e5df9cc9c3991905537e8be31
https://doi.org/10.1038/sj.bjc.6603272
https://doi.org/10.1038/sj.bjc.6603272
Autor:
D Thompson, Ian M. Frayling, M. A. Ponder, Doug Easton, Diana Baralle, Leslie G. Walker, B. A. J. Ponder
Publikováno v:
British Journal of Cancer
Neurofibromatosis type 1 (NF1) is an autosomal dominant condition affecting around one in 3000 live births. The manifestations of this condition are extremely variable, even within families, and genetic counselling is consequently difficult with rega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ebabb89c5a55dcdbf5ffc8fa275100
http://europepmc.org/articles/PMC2360616
http://europepmc.org/articles/PMC2360616
Autor:
Clare Jordan, Robert Luben, Craig Luccarini, Doug Easton, Alison M. Dunning, B. A. J. Ponder, Paul D.P. Pharoah, Shahana Ahmed, Fabienne Lesueur, Honglin Song
Publikováno v:
British Journal of Cancer
A substantial proportion of the familial risk of breast cancer may be attributable to genetic variants each contributing a small effect. pRb controls the cell cycle and polymorphisms within it are candidates for such low penetrance susceptibility all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20986e0556d36cf231b220064c13ba0d
https://doi.org/10.1038/sj.bjc.6603160
https://doi.org/10.1038/sj.bjc.6603160
Publikováno v:
Cold Spring Harbor Symposia on Quantitative Biology. 70:35-41
The known breast cancer predisposing genes account for only about 20% of inherited susceptibility. Epidemiological analyses suggest that much of the remaining 80% is explained by the combined effect of many individually weak genetic variants, rather
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a808a1607ad30f13166b45e7efe848c
https://doi.org/10.1101/sqb.2005.70.029
https://doi.org/10.1101/sqb.2005.70.029
Autor:
Saundra S. Buys, M. Daly, P. D. P Pharoah, M S Piver, Ingrid Oakley-Girvan, Alice S. Whittemore, Richard A. DiCioccio, Raymond R. Balise, M B Usinowicz, John L. Hopper, Ruby T. Senie, Esther M. John, Susan J. Ramus, Irene L. Andrulis, Kim Garlinghouse-Jones, B. A. J. Ponder
Publikováno v:
British Journal of Cancer
Women with mutations of the genes BRCA1 or BRCA2 are at increased risk of ovarian cancer. Oral contraceptives protect against ovarian cancer in general, but it is not known whether they protect against the disease in carriers of these mutations. We o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438f0ef3119b9b1009794a8f2eac9227
https://doi.org/10.1038/sj.bjc.6602239
https://doi.org/10.1038/sj.bjc.6602239
Autor:
Rosalind A. Eeles, Sheila Seal, Maggie Watson, Douglas F. Easton, B. A. J. Ponder, P A Daly, D. Averill, W. Ormiston, S. Lloyd, Victoria Murday
Publikováno v:
Psycho-Oncology. 5:233-239
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5f4f61a37b52e9795c32a46c805b81d
https://doi.org/10.1002/(sici)1099-1611(199609)5:3<233::aid-pon238>3.0.co
https://doi.org/10.1002/(sici)1099-1611(199609)5:3<233::aid-pon238>3.0.co
Autor:
Louise Parker, Teare, Alison M. Dunning, Kataja, D S Chase, Catherine S. Healey, Robert Luben, Jenny Chang-Claude, John Burn, Paul D.P. Pharoah, Arto Mannermaa, David G. Huntsman, Doug Easton, B. A. J. Ponder
Publikováno v:
Nature Genetics. 26:362-364
Inherited mutations in the gene BRCA2 predispose carriers to early onset breast cancer, but such mutations account for fewer than 2% of all cases in East Anglia. It is likely that low penetrance alleles explain the greater part of inherited susceptib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44d186fc3be86b0e04b9515e88c9260
https://doi.org/10.1038/81691
https://doi.org/10.1038/81691