Výsledky vyhledávání - "B. A. Degnan"

Errors during the preparation of drug infusions: a randomized controlled trial

Autor: L. J. Murray, Ari Ercole, Vaithianadan Mani, Daniel W. Wheeler, Arun K. Gupta, Ram Adapa, C. E. Williams, B. Cadman, B. A. Degnan

Publikováno v: British Journal of Anaesthesia. 109:729-734

Background We investigated the extent and frequency of dose errors and treatment delays made as a consequence of preparing drug infusions at the bedside, rather than using pre-filled syringes. Methods Forty-eight nurses with critical care experience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52793a0bbbf10e088b95570088f28479
https://doi.org/10.1093/bja/aes257

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Variability in the concentrations of intravenous drug infusions prepared in a critical care unit

Autor: Arun K. Gupta, Daniel W. Wheeler, Rowan M Burnstein, David K. Menon, B. A. Degnan, Jobanpreet Singh Sehmi

Publikováno v: Intensive Care Medicine. 34:1441-1447

To quantify the variability in the concentration of drug infusions prepared on an intensive care unit and establish whether there was a relationship between the quality of syringe labeling and drug preparation. Audit carried out over 3 weeks in May 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6201a3aa625a317ac35d79e1d22a1241
https://doi.org/10.1007/s00134-008-1113-9

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Retention of drug administration skills after intensive teaching

Autor: Arun Kumar Gupta, B. A. Degnan, L. J. Murray, Daniel W. Wheeler, D.F. Wood, Helen L. Smith, K. D. Whittlestone, C. P. Dunling

Publikováno v: Anaesthesia. 63:379-384

We have identified deficiencies in medical students' drug administration skills, and we attempted to address them with interactive online teaching modules and simulated critical incident scenarios. Short-term improvements have been evident with this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0958d90ad81ff2a126c5dca5875908
https://doi.org/10.1111/j.1365-2044.2007.05379.x

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Synergistic induction of matrix metalloproteinase 1 by interleukin-1? and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism

Autor: Constance E. Brinckerhoff, B. A. Degnan, P. J. T. Koshy, W. D. Shingleton, Andrew D. Rowan, Joni L. Rutter, Jon B. Catterall, Tim E. Cawston, S. Carrère

Publikováno v: Arthritis & Rheumatism. 44:2296-2310

Objective To investigate the mechanism of interleukin-1α (IL-1α) and oncostatin M (OSM) synergistic regulation of matrix metalloproteinase 1 (MMP-1) in human chondrocytes. Methods Using an immortalized human chondrocyte cell line (T/C28a4), we inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bdf153701c6cac9d77bbf2528138745
https://doi.org/10.1002/1529-0131(200110)44:10<2296::aid-art392>3.0.co

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Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown

Autor: P. J. T. Koshy, K. Hudson, Andrew D. Rowan, W. D. Shingleton, B. A. Degnan, P. F. Life, A. B. Vernallis, J. R. Spaull, Tim E. Cawston, John K. Heath

Publikováno v: Arthritis & Rheumatism. 44:1620-1632

Objective To determine whether other glycoprotein 130 (gp130) binding cytokines can mimic the effects of oncostatin M (OSM) in acting synergistically with interleukin-1α (IL-1α) to induce cartilage collagen breakdown and collagenase expression, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd4df44f84b382285dcfd183c0c37b28
https://doi.org/10.1002/1529-0131(200107)44:7<1620::aid-art285>3.0.co

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Characterization of an Isogenic Mutant of Streptococcus pyogenes Manfredo Lacking the Ability To Make Streptococcal Acid Glycoprotein

Autor: B. A. Degnan, M. C. Fontaine, Michael A. Kehoe, Pietro Mastroeni, A. H. Doebereiner, John Goodacre, G. Dougan, Jeong Jin Lee

Publikováno v: Infection and Immunity. 68:2441-2448

An isogenic mutant of Streptococcus pyogenes Manfredo that lacks the ability to make streptococcal acid glycoprotein (SAGP) has been constructed by inserting a deletion in the sagp gene using the method of allelic exchange. An assay of cell extracts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c4d6f7661413784955b4d1d493a3c7
https://doi.org/10.1128/iai.68.5.2441-2448.2000

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Inhibition of Human Peripheral Blood Mononuclear Cell Proliferation by Streptococcus pyogenes Cell Extract Is Associated with Arginine Deiminase Activity

Autor: M. Fischer, C. E. D. Jones, M. Glanville, J. M. Palmer, B. A. Degnan, Austin G. Diamond, John Goodacre, T. Robson, Michael A. Kehoe, G. D. Mellor

Publikováno v: Infection and Immunity. 66:3050-3058

Streptococcus pyogenes (group A Streptococcus ) cell extracts (CE) have a remarkably powerful and dose-dependent inhibitory effect on antigen, superantigen, or mitogen-stimulated human peripheral blood mononuclear cell (PBMC) proliferation in vitro.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23feea02d914f1805f829d4dc165ebfd
https://doi.org/10.1128/iai.66.7.3050-3058.1998

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Transport and metabolism of glucose and arabinose in Bifidobacterium breve

Autor: G T Macfarlane, B A Degnan

Publikováno v: Archives of Microbiology. 160:144-151

Glucose was required for the transport of arabinose into Bifidobacterium breve. The non-metabolisable glucose analogue 2-deoxy-D-glucose (2-DG) did not facilitate assimilation of arabinose. Studies using D-[U-14C]-labelled arabinose showed that it wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb67197babddd9336d863be488e7a597
https://doi.org/10.1007/bf00288717

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