βAdrenergic stimulation induces histone deacetylase 5 (HDAC5) nuclear accumulation in cardiomyocytes by B55α-PP2A-mediated dephosphorylation

Autor: Weeks, Kate L., Ranieri, Antonella, Karaś, Agnieszka, Bernardo, Bianca C., ASHCROFT, Alexandra, Molenaar, Chris, McMullen, Julie R., Avkiran, Metin

Publikováno v: Weeks, K L, Ranieri, A, Karaś, A, Bernardo, B C, ASHCROFT, A, Molenaar, C, McMullen, J R & Avkiran, M 2017, ' βAdrenergic stimulation induces histone deacetylase 5 (HDAC5) nuclear accumulation in cardiomyocytes by B55α-PP2A-mediated dephosphorylation ', Journal of the American Heart Association, vol. 6, no. 4, e004861, pp. 1-14 . https://doi.org/10.1161/JAHA.116.004861

Background--Class IIa histone deacetylase (HDAC) isoforms such as HDAC5 are critical signal-responsive repressors of maladaptive cardiomyocyte hypertrophy, through nuclear interactions with transcription factors including myocyte enhancer factor-2. �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2761::533f949038fd2f28dd82b482485ec130
https://kclpure.kcl.ac.uk/en/publications/fa53a80a-c4e0-4a95-8f6f-5e730c1af186

Mathematical modeling improves EC50 estimations from classical dose–response curves

Autor: Gunnar Cedersund, Ida Cervin, Jordi Altimiras, Elin Nyman, Isa Lindgren, William Lövfors, Karin Lundengård, Theresia Arbring Sjöström

The β-adrenergic response is impaired in failing hearts. When studying β-adrenergic function in vitro, the half-maximal effective concentration (EC50 ) is an important measure of ligand response. We previously measured the in vitro contraction forc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6028935ae373072697082f228938891
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-114788