Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study

Autor: Jennifer J. Wilkes, Henrique Bittencourt, Francesco Ceppi, Javier Oesterheld, Richard Sposto, Yoav Messinger, Susan R. Rheingold, Maria Luisa Sulis, David S. Ziegler, Rebecca Gardner, Weili Sun, Andrew E. Place, Robyn M. Dennis, Todd Cooper, Nobuko Hijiya, Anupam Verma, Yousif Matloub, Michelle L. Hermiston, Melissa Widener, Alan S. Wayne, Paul S. Gaynon, Kirk R. Schultz, Kenneth Heym, Van Huynh, Luciano Dalla-Pozza, Raymond J. Hutchinson, James A. Whitlock, Bill H. Chang, Jemily Malvar, Theodore W. Laetsch

Publikováno v: Leukemia, vol. 32, no. 11, pp. 2316-2325
Leukemia, vol 32, iss 11
Leukemia

The survival of pediatric patients with multiply relapsed and/or refractory (R/R) B-cell acute lymphoblastic leukemia has historically been very poor; however, data are limited in the current era. We conducted a retrospective study to determine the o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7e63e383e4c283537e733bde29e451
https://doi.org/10.1038/s41375-018-0094-0

Type i CD20 antibodies recruit the B cell receptor for complement-dependent lysis of malignant B cells

Autor: Paul W. H. I. Parren, Marleen Voorhorst, Patrick J. Engelberts, Tom Vink, Frank J. Beurskens, Thomas Valerius, Wendy J.M. Mackus, Joost M. Bakker, Stefanie Derer, Tom van Meerten, Esther C.W. Breij, Janine Schuurman, Jan G. J. van de Winkel

Publikováno v: Engelberts, P J, Voorhorst, M, Schuurman, J, Van Meerten, T, Bakker, J M, Vink, T, Mackus, W J M, Breij, E C W, Derer, S, Valerius, T, van de Winkel, J G J, Parren, P W H I & Beurskens, F J 2016, ' Type i CD20 antibodies recruit the B cell receptor for complement-dependent lysis of malignant B cells ', Journal of Immunology, vol. 197, no. 12, pp. 4829-4837 . https://doi.org/10.4049/jimmunol.1600811
Journal of Immunology, 197(12), 4829-4837. AMER ASSOC IMMUNOLOGISTS

Human IgG1 type I CD20 Abs, such as rituximab and ofatumumab (OFA), efficiently induce complement-dependent cytotoxicity (CDC) of CD20+ B cells by binding of C1 to hexamerized Fc domains. Unexpectedly, we found that type I CD20 Ab F(ab')2 fragments,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d9197ec28f899d5e6a016465f31efa
https://portal.findresearcher.sdu.dk/da/publications/34aca668-9af2-49ed-945c-3a69d108b381

Do new biologics meet the unmet medical need in rheumatoid arthritis? Safety and efficacy of abatacept following B-cell depletion

Autor: Walker, Ulrich A, Courvoisier, Delphine S, Dudler, Jean, Aeberli, Daniel, von Kempis, Johannes, Scherer, Almut, Finckh, Axel, on behalf of the, Swiss Clinical Quality Management Programme in Rheumatic Disease

Publikováno v: Walker, Ulrich A; Courvoisier, Delphine S; Dudler, Jean; Aeberli, Daniel; von Kempis, Johannes; Scherer, Almut; Finckh, Axel; on behalf of the, Swiss Clinical Quality Management Programme in Rheumatic Disease (2011). Do new biologics meet the unmet medical need in rheumatoid arthritis? Safety and efficacy of abatacept following B-cell depletion. Rheumatology, 50(1), pp. 243-244. Oxford: Oxford University Press 10.1093/rheumatology/keq258
Rheumatology, Vol. 50, No 1 (2011) pp. 243-4
Rheumatology, vol. 50, no. 1, pp. 243-244

Sir, anti TNF-α agents (aTNFs) are the most commonly prescribed biological agents in RA. More recently abatacept (ABA), a T-cell costimulation modulator, and rituximab (RTX), a monoclonal antibody directed against CD20, have become available. Observ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e7ff88e6280ec628ec59c924fda889
https://boris.unibe.ch/1640/1/keq258.pdf

Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors

Autor: David Deperthes, Takao Kataoka, Jürgen Engel, Jacqueline Romero, Nils Holler, Pedro Romero, Pascal Schneider, Jean-Luc Bodmer, Jürg Tschopp

Publikováno v: Journal of Immunological Methods, vol. 237, no. 1-2, pp. 159-173

TNF receptor family members fused to the constant domain of immunoglobulin G have been widely used as immunoadhesins in basic in vitro and in vivo research and in some clinical applications. In this study, we assemble soluble, high avidity chimeric r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d98abe1adc5f23e0e9aa537d56a090
https://serval.unil.ch/notice/serval:BIB_69A67AAF39A6

Recombinant murine IL-3 fails to stimulate T or B lymphopoiesis in vivo, but enhances immune responses to T cell-dependent antigens

Autor: Kimoto, M., Vincent Kindler, Higaki, M., Ody, C., Izui, S., Vassalli, P.

Publikováno v: Journal of Immunology, Vol. 140, No 6 (1988) pp. 1889-1894
Scopus-Elsevier

We have explored the in vivo effect of IL-3 on the lymphopoiesis and humoral responses of mice bearing osmotic minipumps loaded with murine rIL-3 for 1 to 4 wk. A marked splenomegaly due to the accumulation of hemopoietic precursors was seen, but no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1accded12084ddc2c8567df038fc119f
https://pubmed.ncbi.nlm.nih.gov/3257991