Zobrazeno 1 - 10
of 178
pro vyhledávání: '"B-Cell Receptor Repertoire"'
Autor:
Yohei Funakoshi, Kimikazu Yakushijin, Goh Ohji, Takaji Matsutani, Kazuhiko Doi, Hironori Sakai, Tomoki Sasaki, Takahiro Kusakabe, Sakuya Matsumoto, Yasuyuki Saito, Shinichiro Kawamoto, Katsuya Yamamoto, Taiji Koyama, Yoshiaki Nagatani, Keiji Kurata, Shiro Kimbara, Yoshinori Imamura, Naomi Kiyota, Mitsuhiro Ito, Hironobu Minami
Publikováno v:
eJHaem, Vol 5, Iss 4, Pp 661-668 (2024)
Abstract Monovalent Omicron XBB.1.5 mRNA vaccines were newly developed and approved by the FDA in Autumn 2023 for preventing COVID‐19. However, clinical efficacy for these vaccines is currently lacking. We previously established the quantification
Externí odkaz:
https://doaj.org/article/4e80912d8731416b882b2610fa7fdb8e
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The adaptive immune system generates a diverse array of B-cell receptors through the processes of V(D)J recombination and somatic hypermutation. B-cell receptors that bind to an antigen will undergo clonal expansion, creating a Darwinian evolutionary
Externí odkaz:
https://doaj.org/article/ce8d1bf9630242b0b0db4949dda4065b
Autor:
Goh Ohji, Yohei Funakoshi, Kimikazu Yakushijin, Takaji Matsutani, Tomoki Sasaki, Takahiro Kusakabe, Sakuya Matsumoto, Taiji Koyama, Yoshiaki Nagatani, Keiji Kurata, Shiro Kimbara, Naomi Kiyota, Hironobu Minami
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
A monovalent Omicron XBB.1.5 mRNA RBD analogue vaccine, MAFB-7256a (DS-5670d), was newly developed and approved in Japan in the Spring of 2024 for the prevention of COVID-19. However, clinical efficacy data for this vaccine are currently lacking. We
Externí odkaz:
https://doaj.org/article/59a011b3f9d04db7af323572148f920d
Autor:
Sabrina Pollastro, Anne Musters, Giulia Balzaretti, Ilse Niewold, Barbera van Schaik, Signe Hässler, Catharina M. Verhoef, Marc Pallardy, Antoine van Kampen, Xavier Mariette, Niek de Vries, on behalf of the ABIRISK Consortium
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-10 (2024)
Abstract Background Although B-cell depleting therapy in rheumatoid arthritis (RA) is clearly effective, response is variable and does not correlate with B cell depletion itself. Methods The B-cell receptor (BCR) repertoire was prospectively analyzed
Externí odkaz:
https://doaj.org/article/ecdf69d1480741139ed72b2a3f836118
Autor:
Daria Balashova, Barbera D. C. van Schaik, Maria Stratigopoulou, Jeroen E. J. Guikema, Tom G. Caniels, Mathieu Claireaux, Marit J. van Gils, Anne Musters, Dornatien C. Anang, Niek de Vries, Victor Greiff, Antoine H. C. van Kampen
Publikováno v:
BMC Immunology, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract The reconstruction of clonal families (CFs) in B-cell receptor (BCR) repertoire analysis is a crucial step to understand the adaptive immune system and how it responds to antigens. The BCR repertoire of an individual is formed throughout lif
Externí odkaz:
https://doaj.org/article/4721851a60424610a3e66446a8304cfe
Autor:
Melanie de Gier, Ingrid Pico-Knijnenburg, Monique M. van Ostaijen-ten Dam, Dagmar Berghuis, Frans J. Smiers, Adriaan A. van Beek, Hetty Jolink, Patty M. Jansen, Arjan C. Lankester, Mirjam van der Burg
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for various hematological, immunological and metabolic diseases, replacing the patient’s hematopoietic system with donor-derived healthy hematopoietic stem cells. HSC
Externí odkaz:
https://doaj.org/article/43cc956a59494f48bfa1c4c189550255
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract B cell receptor (BCR) genes exposed to an antigen undergo somatic hypermutations and Darwinian antigen selection, generating a large BCR-antibody diversity. This process, known as B cell affinity maturation, increases antibody affinity, form
Externí odkaz:
https://doaj.org/article/fa415f8038d84a91b7f6089821856e9d
Akademický článek
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Akademický článek
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Autor:
Hyunho Lee, Duck Kyun Yoo, Jerome Han, Ki Hyun Kim, Jinsung Noh, Yonghee Lee, Eunjae Lee, Sunghoon Kwon, Junho Chung
Publikováno v:
FEBS Open Bio, Vol 12, Iss 9, Pp 1634-1643 (2022)
B cells recognize antigens via membrane‐expressed B‐cell receptors (BCR) and antibodies. Similar human BCR sequences are frequently found at a significantly higher frequency than that theoretically calculated. Patients infected with SARS‐CoV2 a
Externí odkaz:
https://doaj.org/article/213945ac06d84830b567b9c1db043a6f