Zobrazeno 1 - 10
of 500
pro vyhledávání: '"B cell tolerance"'
Autor:
Youngjae Hong, Kihyuck Kwak
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
B cells are the cornerstone of our body’s defense system, producing precise antibodies and safeguarding immunological memory for future protection against pathogens. While we have a thorough understanding of how naïve B cells differentiate into pl
Externí odkaz:
https://doaj.org/article/0f292592995c4b4992c1e0adaf1eb138
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1364 (2024)
Protein kinase C delta (PKCδ) has emerged as a key protective molecule against systemic lupus erythematosus (SLE or lupus), an autoimmune disease characterized by anti-double stranded (ds) DNA IgGs. Although PKCδ-deficient mice and lupus patients w
Externí odkaz:
https://doaj.org/article/c04dc15419fd4cc1a7d5c637d15c83bc
Autor:
Qing Min, Krisztian Csomos, Yaxuan Li, Lulu Dong, Ziying Hu, Xin Meng, Meiping Yu, Jolan E. Walter, Ji-Yang Wang
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Mutations in the recombination activating gene 1 (RAG1) and RAG2 in humans are associated with a broad spectrum of clinical phenotypes, from severe combined immunodeficiency to immune dysregulation. Partial (hypomorphic) RAG deficiency (pRD) in parti
Externí odkaz:
https://doaj.org/article/2c3714d87b45462698adacb97af335af
Autor:
Elif Çakan, Gurcan Gunaydin
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Activation induced cytidine deaminase (AID) protein is a member of APOBEC family. AID converts cytidine to uracil, which is a key step for somatic hypermutation (SHM) and class switch recombination (CSR). AID also plays critical roles in B cell precu
Externí odkaz:
https://doaj.org/article/65da46fbec424d6fade642327610d875
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/f7e21a43f9d84f5db260f1ece2729cff
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Antibodies are theoretically limitless in their diversity and specificity to foreign antigens; however they are constrained by the need to avoid binding to self. Germinal centers (GC) allow diversification and maturation of the antibody response towa
Externí odkaz:
https://doaj.org/article/bbdbad66e54e4111ae9cebb859f70819
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Interleukins 4 (IL-4) and 21 (IL-21) belong to the common gamma chain cytokine family which are highly involved in the progression of autoimmune diseases. While IL-4 is well known to be involved in the suppression of apoptosis of autoreactive B cells
Externí odkaz:
https://doaj.org/article/cea354172d654d7aa1dc53655fd7e141
Autor:
Fengge Ma, Yating Zhan, Rocío Bartolomé-Cabrero, Wei Ying, Masahide Asano, Zhe Huang, Changchun Xiao, Alicia González-Martín
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
A microRNA (miRNA) often regulates the expression of hundreds of target genes. A fundamental question in the field of miRNA research is whether a miRNA exerts its biological function through regulating a small number of key targets or through small c
Externí odkaz:
https://doaj.org/article/ecfc024c2cf4473db512b45cf640eea7
Autor:
Hsuan Su, Kazuhiro Imai, Wei Jia, Zhiguo Li, Rachel A. DiCioccio, Jonathan S. Serody, Jonathan C. Poe, Benny J. Chen, Phuong L. Doan, Stefanie Sarantopoulos
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
De novo immune responses to myeloid and other blood-borne tumors are notably limited and ineffective, making our ability to promote immune responses with vaccines a major challenge. While focus has been largely on cytotoxic cell-mediated tumor eradic
Externí odkaz:
https://doaj.org/article/e5191fc99d69408f89ec5efebfa81933
Autor:
Jacqueline A. Wright, Cassandra Bazile, Emily S. Clark, Gianluca Carlesso, Justin Boucher, Eden Kleiman, Tamer Mahmoud, Lily I. Cheng, Darlah M. López-Rodríguez, Anne B. Satterthwaite, Norman H. Altman, Eric L. Greidinger, Wasif N. Khan
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
While apoptosis plays a role in B-cell self-tolerance, its significance in preventing autoimmunity remains unclear. Here, we report that dysregulated B cell apoptosis leads to delayed onset autoimmune phenotype in mice. Our longitudinal studies revea
Externí odkaz:
https://doaj.org/article/eab5bbc02d4a4b57baacd503e0b3f214