Zobrazeno 1 - 10
of 169
pro vyhledávání: '"B cell receptor repertoire"'
Autor:
Yohei Funakoshi, Kimikazu Yakushijin, Goh Ohji, Takaji Matsutani, Kazuhiko Doi, Hironori Sakai, Tomoki Sasaki, Takahiro Kusakabe, Sakuya Matsumoto, Yasuyuki Saito, Shinichiro Kawamoto, Katsuya Yamamoto, Taiji Koyama, Yoshiaki Nagatani, Keiji Kurata, Shiro Kimbara, Yoshinori Imamura, Naomi Kiyota, Mitsuhiro Ito, Hironobu Minami
Publikováno v:
eJHaem, Vol 5, Iss 4, Pp 661-668 (2024)
Abstract Monovalent Omicron XBB.1.5 mRNA vaccines were newly developed and approved by the FDA in Autumn 2023 for preventing COVID‐19. However, clinical efficacy for these vaccines is currently lacking. We previously established the quantification
Externí odkaz:
https://doaj.org/article/4e80912d8731416b882b2610fa7fdb8e
Autor:
Melanie de Gier, Ingrid Pico-Knijnenburg, Monique M. van Ostaijen-ten Dam, Dagmar Berghuis, Frans J. Smiers, Adriaan A. van Beek, Hetty Jolink, Patty M. Jansen, Arjan C. Lankester, Mirjam van der Burg
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for various hematological, immunological and metabolic diseases, replacing the patient’s hematopoietic system with donor-derived healthy hematopoietic stem cells. HSC
Externí odkaz:
https://doaj.org/article/43cc956a59494f48bfa1c4c189550255
Autor:
Sabrina Pollastro, Anne Musters, Giulia Balzaretti, Ilse Niewold, Barbera van Schaik, Signe Hässler, Catharina M. Verhoef, Marc Pallardy, Antoine van Kampen, Xavier Mariette, Niek de Vries, on behalf of the ABIRISK Consortium
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-10 (2024)
Abstract Background Although B-cell depleting therapy in rheumatoid arthritis (RA) is clearly effective, response is variable and does not correlate with B cell depletion itself. Methods The B-cell receptor (BCR) repertoire was prospectively analyzed
Externí odkaz:
https://doaj.org/article/ecdf69d1480741139ed72b2a3f836118
Autor:
Daria Balashova, Barbera D. C. van Schaik, Maria Stratigopoulou, Jeroen E. J. Guikema, Tom G. Caniels, Mathieu Claireaux, Marit J. van Gils, Anne Musters, Dornatien C. Anang, Niek de Vries, Victor Greiff, Antoine H. C. van Kampen
Publikováno v:
BMC Immunology, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract The reconstruction of clonal families (CFs) in B-cell receptor (BCR) repertoire analysis is a crucial step to understand the adaptive immune system and how it responds to antigens. The BCR repertoire of an individual is formed throughout lif
Externí odkaz:
https://doaj.org/article/4721851a60424610a3e66446a8304cfe
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract B cell receptor (BCR) genes exposed to an antigen undergo somatic hypermutations and Darwinian antigen selection, generating a large BCR-antibody diversity. This process, known as B cell affinity maturation, increases antibody affinity, form
Externí odkaz:
https://doaj.org/article/fa415f8038d84a91b7f6089821856e9d
Autor:
Yuka Takehara, Kosaku Mimura, Yoshiyuki Suzuki, Yohei Watanabe, Yuya Yoshimoto, Zenichiro Saze, Hisashi Sato, Tomoaki Tamaki, Koji Kono
Publikováno v:
Cancer Reports, Vol 6, Iss 7, Pp n/a-n/a (2023)
Abstract Background Several clinical trials of nivolumab have reported good results, including those in patients with advanced esophageal squamous cell carcinoma. However, the response rate of this drug remains poor. Notably, a rare phenomenon called
Externí odkaz:
https://doaj.org/article/f7a836f6223d46b0844d2653111fbba5
Autor:
Hyunho Lee, Duck Kyun Yoo, Jerome Han, Ki Hyun Kim, Jinsung Noh, Yonghee Lee, Eunjae Lee, Sunghoon Kwon, Junho Chung
Publikováno v:
FEBS Open Bio, Vol 12, Iss 9, Pp 1634-1643 (2022)
B cells recognize antigens via membrane‐expressed B‐cell receptors (BCR) and antibodies. Similar human BCR sequences are frequently found at a significantly higher frequency than that theoretically calculated. Patients infected with SARS‐CoV2 a
Externí odkaz:
https://doaj.org/article/213945ac06d84830b567b9c1db043a6f
Autor:
Carlos Castrillon, Lea Simoni, Theo van den Broek, Cees van der Poel, Elliot H Akama-Garren, Minghe Ma, Michael C Carroll
Publikováno v:
eLife, Vol 12 (2023)
Affinity matured self-reactive antibodies are found in autoimmune diseases like systemic lupus erythematous. Here, we used fate-mapping reporter mice and single-cell transcriptomics coupled to antibody repertoire analysis to characterize the post-ger
Externí odkaz:
https://doaj.org/article/89c2971e118943a3a05cb88795fde559
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