Zobrazeno 1 - 10
of 289
pro vyhledávání: '"B cell receptor (BCR)"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
B cells surveil the body for foreign matter using their surface-expressed B cell antigen receptor (BCR), a tetrameric complex comprising a membrane-tethered antibody (mIg) that binds antigens and a signaling dimer (CD79AB) that conveys this interacti
Externí odkaz:
https://doaj.org/article/01e0ede57de04b9e9e729f528e89d11f
Autor:
Emily Dennis, Maria Murach, Cassidy M.R. Blackburn, Melissa Marshall, Katherine Root, Tanyaporn Pattarabanjird, Justine Deroissart, Loren D. Erickson, Christoph J. Binder, Stefan Bekiranov, Coleen A. McNamara
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Recent studies have demonstrated a role for Ten-Eleven Translocation-2 (TET2), an epigenetic modulator, in regulating germinal center formation and plasma cell differentiation in B-2 cells, yet the role of TET2 in regulating B-1 cells is largely unkn
Externí odkaz:
https://doaj.org/article/e381fe19acd54eb697d2fdd0ef3acea1
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The vast diversity of mammalian adaptive antigen receptors allows for robust and efficient immune responses against a wide number of pathogens. The antigen receptor repertoire is built during the recombination of B and T cell receptor (BCR, TCR) loci
Externí odkaz:
https://doaj.org/article/601882d9b48f4210b5bcabc749d86146
Autor:
Vera K. Schmid, Elias Hobeika
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
B cell antigen receptor (BCR) signaling is a key driver of growth and survival in both normal and malignant B cells. Several lines of evidence support an important pathogenic role of the BCR in chronic lymphocytic leukemia (CLL). The significant impr
Externí odkaz:
https://doaj.org/article/2bd4afbf33b645ff81da7c92582150f8
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionSystemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Anti-B-cell-activating factor (BAFF) therapy effectively depletes B cells and reduces SLE disease activity. This research aimed to evaluate the effect of BAFF block
Externí odkaz:
https://doaj.org/article/ddc78c29396d4232acf8bd7d81e87f29
Autor:
Christin Elster, Miriam Ommer-Bläsius, Alexander Lang, Tanja Vajen, Susanne Pfeiler, Milena Feige, Tin Yau Pang, Marius Böttenberg, Sarah Verheyen, Khang Lê Quý, Maria Chernigovskaya, Malte Kelm, Holger Winkels, Susanne V. Schmidt, Victor Greiff, Norbert Gerdes
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundAn abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Although its pathogenesis is still poorly understood, recent evidence suggests that AAA displays autoimmune disease characteristics. Particularly, T cells resp
Externí odkaz:
https://doaj.org/article/ad3ff214c6db409e9c3438325de72d31
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The immune system is strictly regulated by glycosylation through the addition of highly diverse and dynamically changing sugar structures (glycans) to the majority of immune cell receptors. Although knowledge in the field of glycoimmunology is still
Externí odkaz:
https://doaj.org/article/46ffda1263244f8083c7b1eb91ef0ce0
Akademický článek
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Autor:
Paaksum Wong, Davide P. Cina, Karen R. Sherwood, Franz Fenninger, Ruth Sapir-Pichhadze, Constantin Polychronakos, James Lan, Paul A. Keown
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundMeasurement of T cell receptor (TCR) or B cell receptor (BCR) gene utilization may be valuable in monitoring the dynamic changes in donor-reactive clonal populations following transplantation and enabling adjustment in therapy to avoid the
Externí odkaz:
https://doaj.org/article/9641b2ef54fb4d38998a894ab9993624
Autor:
Thomas Clarke, Pan Du, Satyendra Kumar, Shinji L. Okitsu, Mark Schuette, Qi An, Jinyang Zhang, Evgeni Tzvetkov, Mark A. Jensen, Timothy B. Niewold, Elise M. N. Ferre, Julie Nardone, Michail S. Lionakis, Jaromir Vlach, Julie DeMartino, Andrew T. Bender
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Autoimmune diseases vary in the magnitude and diversity of autoantibody profiles, and these differences may be a consequence of different types of breaks in tolerance. Here, we compared the disparate autoimmune diseases autoimmune polyendocrinopathy
Externí odkaz:
https://doaj.org/article/e823a778e94642ba916ed495ae37f622