Defective B-cell-negative selection and terminal differentiation in the ICF syndrome

Autor: Yun Liang Jiang, Bertrand Roquelaure, Claudine Schiff, Isabelle Thuret, Carla Blanco-Betancourt, Anne Moncla, Evani M. Viegas-Péquignot, Michèle Milili

Publikováno v: Blood. 103:2683-2690

Immunodeficiency, centromeric region instability, and facial anomalies (ICF) syndrome is a rare autosomal recessive disease. Mutations in the DNA methyltransferase 3B (DNMT3B) gene are responsible for most ICF cases reported. We investigated the B-ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18e2535b80dbe5497f6744284c544c5
https://doi.org/10.1182/blood-2003-08-2632

Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance

Autor: Michael Leitges, Jeroen P. Roose, Andre Limnander, Tannia Lau, Julie Zikherman, Arthur Weiss

Publikováno v: Limnander, A; Zikherman, J; Lau, T; Leitges, M; Weiss, A; & Roose, JP. (2014). Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance. Molecular and Cellular Biology, 34(8), 1474-1485. doi: 10.1128/MCB.01699-13. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3jj9q4g2
Molecular and cellular biology, vol 34, iss 8

Protein kinase Cδ (PKCδ) deficiency causes autoimmune pathology in humansand mice and is crucial for the maintenance of B cell homeostasis. However, the mechanisms underlying autoimmune disease in PKCδ deficiency remain poorly defined. Here, weadd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a126b50e244ad5de1351a624126551e8
http://www.escholarship.org/uc/item/3jj9q4g2

Low efficiency of a newly introduced high-density microparticles method for B cell depletion in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation

Autor: M. Dassi, Enrico Pogliani, Daniela Belotti, P. Perseghin, P. Pioltelli

Publikováno v: Journal of hematotherapystem cell research. 12(5)

Autologous peripheral blood stem cell (PBSC) transplantation proved to increase complete remission (CR) and DFS in multiple myeloma (MM) patients. CD34(+) cell selection has been used to reduce possible myeloma cell contamination in the graft, but it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07db1aa14a4f9ea3cecedf8c7103a473
https://pubmed.ncbi.nlm.nih.gov/14594510

Does CD40 ligation induce B cell negative selection?

Autor: Jesús Martínez-Barnetche, Richard A. Flavell, Vicente Madrid-Marina, José Moreno

Publikováno v: ResearcherID

Binding of CD154 to its receptor, CD40, provides costimulation for mature B cell activation and differentiation in response to Ag receptor signals. In mice, early B cell precursors express CD40, but its function at this stage is unknown. We examined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc3d484d73bea0d4f66ae1a333739dd
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:11801637&KeyUID=MEDLINE:11801637