Zobrazeno 1 - 10
of 347
pro vyhledávání: '"B cell malignancy"'
Autor:
Qi Zhang, Chengxiang Xia, Qitong Weng, Leqiang Zhang, Yao Wang, Yanhong Liu, Xiujuan Zheng, Yunqing Lin, Yi Chen, Yiyuan Shen, Hanmeng Qi, Lijuan Liu, Yanping Zhu, Min Zhang, Dehao Huang, Fangxiao Hu, Mengyun Zhang, Hui Zeng, Jinyong Wang, Tongjie Wang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundChimeric antigen receptor (CAR) engineered natural killer (NK) cells exhibit advantages such as MHC-independent recognition and strong anti-tumor functions. However, allogeneic CAR-NK cells derived from human tissues are heterogeneous and s
Externí odkaz:
https://doaj.org/article/e1379ef2c2304eca9c37bfdc2752dedb
Autor:
Xiao Yang, Huichen Bai, Xi Yuan, Xiaolong Yang, Ye Liu, Mingming Guo, Nan Hu, Beibei Jiang, Zeqin Lian, Zhilong Ma, Jingyuan Wang, Xuebing Sun, Taichang Zhang, Dan Su, Yue Wu, Jing Li, Fan Wang, Zhiwei Wang, Lai Wang, Xuesong Liu, Xiaomin Song
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101053- (2024)
PI3Kδ is a key signal transduction molecule in normal and malignant B cells, as well as in T-regulatory cells, making it a promising target for treatment of hematologic malignancies through both direct killing and anti-tumor immunity regulation. BGB
Externí odkaz:
https://doaj.org/article/6e9ecf70bc114685b74062abcfc58de0
Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Forkhead box (FOX) class O (FOXO) proteins are a dynamic family of transcription factors composed of four family members: FOXO1, FOXO3, FOXO4 and FOXO6. As context-dependent transcriptional activators and repressors, the FOXO family regulates diverse
Externí odkaz:
https://doaj.org/article/7eb6c9ca4b1a4d25b90afdfd74299e6a
Autor:
Lu Han, Jian Zhou, Linlin Li, Keshu Zhou, Lingdi Zhao, Xinghu Zhu, Qingsong Yin, Yufu Li, Hongqin You, Jishuai Zhang, Yongping Song, Quanli Gao
Publikováno v:
Cancer Biology & Medicine, Vol 18, Iss 4, Pp 1066-1079 (2021)
Objective: Chimeric antigen receptor-modified T (CAR-T) cells have shown impressive results against relapsed/refractory B cell malignancies. However, the traditional manufacture of CAR-T cells requires leukapheresis to isolate large amounts of periph
Externí odkaz:
https://doaj.org/article/b31ae4dc1bc947628b4a687150159dd3
Autor:
Robert J. Kreitman, Claire Dearden, Pier Luigi Zinzani, Julio Delgado, Tadeusz Robak, Philipp D. le Coutre, Bjørn T. Gjertsen, Xavier Troussard, Gail J. Roboz, Lionel Karlin, Douglas E. Gladstone, Nataliya Kuptsova-Clarkson, Shiyao Liu, Priti Patel, Federico Rotolo, Emmanuel Mitry, Ira Pastan, Francis Giles, the Study 1053 investigators
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-11 (2021)
Abstract Background Moxetumomab pasudotox is a recombinant CD22-targeting immunotoxin. Here, we present the long-term follow-up analysis of the pivotal, multicenter, open-label trial (NCT01829711) of moxetumomab pasudotox in patients with relapsed/re
Externí odkaz:
https://doaj.org/article/036b0eca00dd402a9a89af31dbc023b1
Autor:
Weam Othman Elbezanti, Kishore B. Challagundla, Subash C. Jonnalagadda, Tulin Budak-Alpdogan, Manoj K. Pandey
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 415 (2023)
Multiple myeloma (MM) is a challenging hematological cancer which typically grows in bone marrow. MM accounts for 10% of hematological malignancies and 1.8% of cancers. The recent treatment strategies have significantly improved progression-free surv
Externí odkaz:
https://doaj.org/article/ab2e1b0464064d68991d012df6bd5c4a
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Autor:
Dhruv Sanjay Gupta, Vaishnavi Gadi, Ginpreet Kaur, Meena Chintamaneni, Hardeep Singh Tuli, Seema Ramniwas, Gautam Sethi
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 221 (2023)
The growing incidence of B cell malignancies globally has prompted research on the pharmacological properties of phytoconstituents in cancer management. Resveratrol, a polyphenolic stilbenoid widely found in nature, has been explored for its anti-inf
Externí odkaz:
https://doaj.org/article/b5cad781fd2d4b768fc75e7190af3622
Autor:
Agnieszka Tomaszewska, Madan Jagasia, Eric Beohou, Steffie van der Werf, Didier Blaise, Edward Kanfer, Noel Milpied, Péter Reményi, Fabio Ciceri, Jean H. Bourhis, Patrice Chevallier, Carlos Solano, Gerard Socié, Benedetto Bruno, Alessandro Rambaldi, Luca Castagna, Nicolaus Kröger, Paolo Corradini, Boris Afanasyev, Marco Ladetto, Dietger Niederwieser, Christof Scheid, Henrik Sengeloev, Frank Kroschinsky, Ibrahim Yakoub-Agha, Helene Schoemans, Christian Koenecke, Olaf Penack, Zinaida Perić, Hildegard Greinix, Rafael F. Duarte, Grzegorz W. Basak
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Rituximab (R) is increasingly incorporated in reduced intensity conditioning (RIC) regimens for allogeneic hematopoietic cell transplantation (alloHCT) in patients with B-cell malignancies, not only to improve disease control, but also to prevent gra
Externí odkaz:
https://doaj.org/article/4f239d6d85d44aa8a589abee520c5fad